ENSG00000232284

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000420587 ENSG00000232284 HEK293_OSMI2_2hA HEK293_TMG_2hB GNG12-AS1 lncRNA lncRNA 0.4357587 0.2027923 0.3627695 0.09673783 0.1188882 0.8088375 0.02087534 0.004246193 0.09842542 0.004246193 0.02822121 2.928055 0.12502727 0.3333333 0.4472667 0.1139333 0.72738696 0.03873044 FALSE TRUE
ENST00000434072 ENSG00000232284 HEK293_OSMI2_2hA HEK293_TMG_2hB GNG12-AS1 lncRNA lncRNA 0.4357587 0.2027923 0.3627695 0.09673783 0.1188882 0.8088375 0.08166675 0.000000000 0.23441994 0.000000000 0.12342495 4.611290 0.25689545 0.0000000 0.4992667 0.4992667 0.25394397 0.03873044 FALSE FALSE
ENST00000688125 ENSG00000232284 HEK293_OSMI2_2hA HEK293_TMG_2hB GNG12-AS1 lncRNA lncRNA 0.4357587 0.2027923 0.3627695 0.09673783 0.1188882 0.8088375 0.25035550 0.191376196 0.00000000 0.096425728 0.00000000 -4.331821 0.49499545 0.6449000 0.0000000 -0.6449000 0.03873044 0.03873044   FALSE
MSTRG.1380.5 ENSG00000232284 HEK293_OSMI2_2hA HEK293_TMG_2hB GNG12-AS1 lncRNA   0.4357587 0.2027923 0.3627695 0.09673783 0.1188882 0.8088375 0.06966056 0.000000000 0.00000000 0.000000000 0.00000000 0.000000 0.08824091 0.0000000 0.0000000 0.0000000   0.03873044   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000232284 E001 0.4762024 0.030653499 0.56599392 0.69301817 1 67832297 67832302 6 + 0.145 0.186 0.426
ENSG00000232284 E002 0.4762024 0.030653499 0.56599392 0.69301817 1 67832303 67832308 6 + 0.145 0.186 0.426
ENSG00000232284 E003 1.3630445 0.010585356 0.88006315 0.92708102 1 67832309 67832436 128 + 0.378 0.315 -0.382
ENSG00000232284 E004 0.6986918 0.018457737 0.01542112 0.04144597 1 67873152 67873321 170 + 0.079 0.415 3.011
ENSG00000232284 E005 0.0000000       1 67955405 67955784 380 +      
ENSG00000232284 E006 0.1515154 0.051389527 1.00000000   1 67956156 67956262 107 + 0.079 0.000 -10.567
ENSG00000232284 E007 0.0000000       1 68024519 68024638 120 +      
ENSG00000232284 E008 0.0000000       1 68026574 68026762 189 +      
ENSG00000232284 E009 0.1515154 0.051389527 1.00000000   1 68034647 68034763 117 + 0.079 0.000 -10.567
ENSG00000232284 E010 0.1451727 0.050793514 1.00000000   1 68071800 68071873 74 + 0.079 0.000 -10.566
ENSG00000232284 E011 0.2214452 0.045712750 0.10497498   1 68098643 68098836 194 + 0.000 0.186 13.147
ENSG00000232284 E012 0.8084787 0.025565204 1.00000000 1.00000000 1 68099729 68099792 64 + 0.254 0.186 -0.571
ENSG00000232284 E013 0.1515154 0.051389527 1.00000000   1 68100698 68100774 77 + 0.079 0.000 -10.567
ENSG00000232284 E014 0.1515154 0.051389527 1.00000000   1 68102655 68102727 73 + 0.079 0.000 -10.567
ENSG00000232284 E015 1.8875206 0.009720676 0.66843742 0.77543194 1 68117451 68117732 282 + 0.445 0.415 -0.159
ENSG00000232284 E016 0.0000000       1 68119387 68121124 1738 +      
ENSG00000232284 E017 0.9148410 0.015847295 0.43661880 0.57866924 1 68121125 68121241 117 + 0.254 0.315 0.425
ENSG00000232284 E018 0.0000000       1 68121985 68122203 219 +      
ENSG00000232284 E019 0.8803856 0.018819153 0.83332493 0.89559231 1 68138297 68138356 60 + 0.299 0.185 -0.897
ENSG00000232284 E020 1.0287806 0.013592874 0.13874045 0.24635825 1 68138357 68138450 94 + 0.378 0.000 -13.373
ENSG00000232284 E021 1.1887151 0.019465096 0.10147030 0.19271036 1 68141425 68141788 364 + 0.413 0.000 -13.566
ENSG00000232284 E022 0.7342825 0.019784587 0.27072369 0.40936569 1 68201969 68202987 1019 + 0.299 0.000 -12.888