ENSG00000232022

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000455247 ENSG00000232022 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 3.75257 7.090332 3.335173 0.3748737 0.4186494 -1.085806 0.4339677 0.866484 0.6520856 0.1516291 0.1461402 -0.4047100 0.1033917 0.1215000 0.2008333 0.07933333 4.756524e-01 1.902423e-07 FALSE FALSE
ENST00000635606 ENSG00000232022 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 3.75257 7.090332 3.335173 0.3748737 0.4186494 -1.085806 1.9743463 3.413006 2.2197967 0.1595627 0.2997391 -0.6183516 0.5394375 0.4819667 0.6640333 0.18206667 2.499329e-03 1.902423e-07 FALSE FALSE
ENST00000692135 ENSG00000232022 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 3.75257 7.090332 3.335173 0.3748737 0.4186494 -1.085806 1.2646272 2.790619 0.4632903 0.1638101 0.1143630 -2.5649486 0.3341125 0.3934000 0.1351333 -0.25826667 1.902423e-07 1.902423e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000232022 E001 0.0000000       1 46432129 46432242 114 +      
ENSG00000232022 E002 0.0000000       1 46432490 46432610 121 +      
ENSG00000232022 E003 0.1451727 0.0418038673 1.963968e-01   1 46433024 46433099 76 + 0.178 0.000 -11.946
ENSG00000232022 E004 0.1451727 0.0418038673 1.963968e-01   1 46433738 46433826 89 + 0.178 0.000 -14.057
ENSG00000232022 E005 0.1482932 0.0431191506 1.000000e+00   1 46433827 46433947 121 + 0.000 0.082 11.240
ENSG00000232022 E006 0.0000000       1 46433948 46433951 4 +      
ENSG00000232022 E007 0.1482932 0.0431191506 1.000000e+00   1 46435207 46435248 42 + 0.000 0.082 11.240
ENSG00000232022 E008 0.0000000       1 46435907 46435911 5 +      
ENSG00000232022 E009 0.1482932 0.0431191506 1.000000e+00   1 46435912 46435932 21 + 0.000 0.082 11.240
ENSG00000232022 E010 0.1482932 0.0431191506 1.000000e+00   1 46435933 46436036 104 + 0.000 0.082 11.240
ENSG00000232022 E011 0.0000000       1 46436124 46436144 21 +      
ENSG00000232022 E012 0.0000000       1 46436145 46436248 104 +      
ENSG00000232022 E013 0.0000000       1 46436249 46436453 205 +      
ENSG00000232022 E014 0.0000000       1 46437380 46437491 112 +      
ENSG00000232022 E015 0.0000000       1 46438265 46438346 82 +      
ENSG00000232022 E016 0.1451727 0.0418038673 1.963968e-01   1 46438667 46438682 16 + 0.178 0.000 -14.057
ENSG00000232022 E017 0.0000000       1 46439523 46439577 55 +      
ENSG00000232022 E018 0.0000000       1 46440662 46440665 4 +      
ENSG00000232022 E019 0.0000000       1 46440666 46440701 36 +      
ENSG00000232022 E020 0.0000000       1 46440702 46440705 4 +      
ENSG00000232022 E021 0.0000000       1 46441094 46441096 3 +      
ENSG00000232022 E022 2.0490745 0.0114822069 7.515705e-01 8.379751e-01 1 46441097 46441202 106 + 0.481 0.427 -0.279
ENSG00000232022 E023 0.2965864 0.3068675980 6.873002e-01   1 46442830 46442837 8 + 0.000 0.148 11.818
ENSG00000232022 E024 1.7432903 0.0260460017 2.620345e-01 3.997556e-01 1 46442838 46442861 24 + 0.549 0.352 -1.024
ENSG00000232022 E025 8.2178295 0.0024234647 5.169623e-01 6.514582e-01 1 46442862 46442891 30 + 0.960 0.886 -0.280
ENSG00000232022 E026 10.6449612 0.0019121334 6.367888e-01 7.507421e-01 1 46442892 46442899 8 + 1.047 0.999 -0.177
ENSG00000232022 E027 32.1322217 0.0007390306 8.788745e-01 9.261739e-01 1 46442900 46443020 121 + 1.461 1.453 -0.028
ENSG00000232022 E028 20.2275636 0.0011470452 5.313750e-01 6.638403e-01 1 46443021 46443037 17 + 1.296 1.248 -0.167
ENSG00000232022 E029 0.0000000       1 46443943 46443969 27 +      
ENSG00000232022 E030 7.1783119 0.0027065665 7.072099e-02 1.445388e-01 1 46445199 46445215 17 + 0.658 0.908 0.999
ENSG00000232022 E031 23.8312242 0.0008650360 3.046971e-07 2.815254e-06 1 46445216 46445708 493 + 0.960 1.412 1.614
ENSG00000232022 E032 5.8768875 0.0031291152 3.035850e-01 4.455181e-01 1 46455820 46455910 91 + 0.880 0.748 -0.522
ENSG00000232022 E033 0.3729606 0.0296582166 5.127864e-01 6.476822e-01 1 46477348 46477504 157 + 0.178 0.082 -1.278
ENSG00000232022 E034 27.1573866 0.0008182183 5.617679e-03 1.759822e-02 1 46482210 46482493 284 + 1.511 1.340 -0.591