ENSG00000231889

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000449449 ENSG00000231889 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAF3IP2-AS1 lncRNA lncRNA 7.021318 7.727809 8.933414 0.4819574 0.4884658 0.2089006 1.2111010 0.9469954 2.1838368 0.4742476 0.2219623 1.1968723 0.16996667 0.12283333 0.2467333 0.12390000 6.055487e-01 2.170786e-14   FALSE
ENST00000685477 ENSG00000231889 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAF3IP2-AS1 lncRNA lncRNA 7.021318 7.727809 8.933414 0.4819574 0.4884658 0.2089006 0.8298917 0.5035855 0.8399149 0.2972841 0.6200883 0.7267139 0.12164583 0.06300000 0.1013000 0.03830000 9.544664e-01 2.170786e-14   FALSE
ENST00000687951 ENSG00000231889 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAF3IP2-AS1 lncRNA lncRNA 7.021318 7.727809 8.933414 0.4819574 0.4884658 0.2089006 0.7271438 0.3228409 1.1723427 0.3228409 0.5868198 1.8287435 0.10686667 0.04223333 0.1255000 0.08326667 5.585645e-01 2.170786e-14   FALSE
ENST00000691364 ENSG00000231889 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAF3IP2-AS1 lncRNA lncRNA 7.021318 7.727809 8.933414 0.4819574 0.4884658 0.2089006 2.7317892 4.6343937 2.7243288 0.3107944 0.2259078 -0.7643035 0.37825417 0.59936667 0.3040333 -0.29533333 2.170786e-14 2.170786e-14 FALSE FALSE
MSTRG.28813.5 ENSG00000231889 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAF3IP2-AS1 lncRNA   7.021318 7.727809 8.933414 0.4819574 0.4884658 0.2089006 0.3551310 0.2356524 0.9384397 0.2356524 0.4720792 1.9489375 0.05070417 0.03083333 0.1009333 0.07010000 5.705572e-01 2.170786e-14   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000231889 E001 1.8318706 0.1754450285 9.800464e-01 9.915453e-01 6 111483496 111483498 3 + 0.448 0.445 -0.013
ENSG00000231889 E002 3.3505807 0.0174670698 6.661436e-01 7.736429e-01 6 111483499 111483510 12 + 0.603 0.656 0.228
ENSG00000231889 E003 3.3558661 0.0085257108 9.891988e-01 9.972899e-01 6 111483511 111483511 1 + 0.635 0.620 -0.063
ENSG00000231889 E004 4.0577802 0.0375005105 9.011259e-01 9.409499e-01 6 111483512 111483515 4 + 0.692 0.691 -0.003
ENSG00000231889 E005 6.6521950 0.0244837832 4.001114e-01 5.438402e-01 6 111483516 111483535 20 + 0.828 0.924 0.371
ENSG00000231889 E006 6.2771580 0.0033504736 3.738910e-01 5.183196e-01 6 111483536 111483536 1 + 0.808 0.905 0.376
ENSG00000231889 E007 10.9032220 0.0032967026 7.015805e-01 8.006859e-01 6 111483537 111483549 13 + 1.062 1.088 0.094
ENSG00000231889 E008 12.7186216 0.0031769638 9.856539e-01 9.950663e-01 6 111483550 111483554 5 + 1.145 1.135 -0.034
ENSG00000231889 E009 27.8649658 0.0007835875 3.979470e-01 5.416898e-01 6 111483555 111483611 57 + 1.444 1.485 0.140
ENSG00000231889 E010 36.5714190 0.0007783490 1.042399e-01 1.969475e-01 6 111483612 111483664 53 + 1.537 1.614 0.262
ENSG00000231889 E011 25.1147270 0.0011751719 3.176501e-01 4.605387e-01 6 111483665 111483665 1 + 1.389 1.443 0.186
ENSG00000231889 E012 2.5204472 0.0081386764 8.918411e-01 9.349221e-01 6 111483666 111484117 452 + 0.569 0.539 -0.140
ENSG00000231889 E013 1.3015312 0.0171345205 7.993480e-01 8.720168e-01 6 111484118 111484145 28 + 0.343 0.381 0.223
ENSG00000231889 E014 0.9921577 0.0126465590 2.995551e-01 4.410801e-01 6 111484652 111484743 92 + 0.205 0.381 1.224
ENSG00000231889 E015 32.9309973 0.0011208862 3.648648e-06 2.680727e-05 6 111484744 111484861 118 + 1.378 1.642 0.906
ENSG00000231889 E016 4.7702045 0.0038143245 8.158196e-01 8.834343e-01 6 111490968 111493003 2036 + 0.787 0.746 -0.164
ENSG00000231889 E017 37.6901577 0.0039623360 1.296071e-09 1.881508e-08 6 111503296 111503611 316 + 1.373 1.734 1.238
ENSG00000231889 E018 1.6920986 0.2689787498 4.342791e-01 5.766575e-01 6 111565251 111565282 32 + 0.532 0.311 -1.200
ENSG00000231889 E019 0.1515154 0.0443354776 5.864598e-01   6 111574619 111574620 2 + 0.114 0.000 -10.165
ENSG00000231889 E020 16.2110629 0.0063380030 5.136876e-04 2.210635e-03 6 111574621 111574658 38 + 1.372 1.036 -1.195
ENSG00000231889 E021 30.1256466 0.0008083450 2.767927e-08 3.138094e-07 6 111574659 111574802 144 + 1.644 1.277 -1.264
ENSG00000231889 E022 33.0113296 0.0008221174 2.927898e-02 7.054235e-02 6 111576362 111576470 109 + 1.604 1.464 -0.477
ENSG00000231889 E023 88.4965395 0.0140368293 3.889594e-02 8.898883e-02 6 111576471 111578180 1710 + 2.011 1.888 -0.414
ENSG00000231889 E024 0.3686942 0.0291544680 8.879969e-01 9.324108e-01 6 111586993 111587134 142 + 0.114 0.131 0.227
ENSG00000231889 E025 0.4460135 0.0236078611 1.197852e-01 2.196736e-01 6 111592261 111592293 33 + 0.280 0.000 -11.750
ENSG00000231889 E026 16.6982496 0.0124669309 3.646282e-01 5.089789e-01 6 111597838 111598302 465 + 1.301 1.205 -0.337