ENSG00000231584

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000467292 ENSG00000231584 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 16.04071 26.48986 10.2055 1.085724 0.1931796 -1.375225 2.8111542 4.0229394 1.7293583 0.6085795 0.8823720 -1.2132766 0.16623750 0.15210000 0.16640000 0.01430000 9.286113e-01 9.352949e-24   FALSE
ENST00000686031 ENSG00000231584 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 16.04071 26.48986 10.2055 1.085724 0.1931796 -1.375225 1.1609457 2.9550569 0.0000000 0.1730704 0.0000000 -8.2119160 0.06761667 0.11153333 0.00000000 -0.11153333 9.352949e-24 9.352949e-24   FALSE
ENST00000686623 ENSG00000231584 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 16.04071 26.48986 10.2055 1.085724 0.1931796 -1.375225 0.8771577 1.9254086 1.0882773 0.1660094 0.1366399 -0.8173958 0.05221250 0.07343333 0.10633333 0.03290000 3.292778e-01 9.352949e-24   FALSE
ENST00000687200 ENSG00000231584 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 16.04071 26.48986 10.2055 1.085724 0.1931796 -1.375225 0.8727930 1.1638641 1.0600832 0.6123657 0.3031151 -0.1335425 0.05248750 0.04463333 0.10506667 0.06043333 5.955987e-01 9.352949e-24 FALSE TRUE
ENST00000687350 ENSG00000231584 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 16.04071 26.48986 10.2055 1.085724 0.1931796 -1.375225 0.5221940 0.2981567 0.8664425 0.2981567 0.4401470 1.5079955 0.02981667 0.01050000 0.08586667 0.07536667 4.187666e-01 9.352949e-24 FALSE TRUE
ENST00000689315 ENSG00000231584 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 16.04071 26.48986 10.2055 1.085724 0.1931796 -1.375225 1.3814391 1.2616833 0.7292107 0.7856625 0.3738916 -0.7826820 0.08370000 0.04686667 0.07180000 0.02493333 9.314049e-01 9.352949e-24   FALSE
ENST00000690531 ENSG00000231584 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 16.04071 26.48986 10.2055 1.085724 0.1931796 -1.375225 1.1526469 1.7036429 0.1552133 0.8805575 0.1552133 -3.3746649 0.07796250 0.06193333 0.01496667 -0.04696667 6.011512e-01 9.352949e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000231584 E001 0.1451727 0.0429345584 1.696305e-01   2 96010526 96010531 6 + 0.190 0.000 -10.708
ENSG00000231584 E002 0.1451727 0.0429345584 1.696305e-01   2 96010532 96010534 3 + 0.190 0.000 -12.982
ENSG00000231584 E003 0.2966881 0.0294856487 4.035600e-02   2 96010535 96010542 8 + 0.321 0.000 -14.088
ENSG00000231584 E004 0.5181333 0.0215165477 1.487453e-01 2.599811e-01 2 96010543 96010544 2 + 0.321 0.077 -2.498
ENSG00000231584 E005 0.7395785 0.0191138057 3.207879e-01 4.639497e-01 2 96010545 96010547 3 + 0.321 0.142 -1.496
ENSG00000231584 E006 0.9212829 0.0154455631 5.149051e-01 6.496262e-01 2 96010548 96010550 3 + 0.321 0.199 -0.912
ENSG00000231584 E007 0.7761102 0.0181523285 9.849071e-01 9.946028e-01 2 96010551 96010552 2 + 0.190 0.199 0.089
ENSG00000231584 E008 0.7761102 0.0181523285 9.849071e-01 9.946028e-01 2 96010553 96010553 1 + 0.190 0.199 0.089
ENSG00000231584 E009 0.7761102 0.0181523285 9.849071e-01 9.946028e-01 2 96010554 96010556 3 + 0.190 0.199 0.089
ENSG00000231584 E010 0.7761102 0.0181523285 9.849071e-01 9.946028e-01 2 96010557 96010557 1 + 0.190 0.199 0.089
ENSG00000231584 E011 1.2210915 0.0118175178 3.532042e-01 4.974374e-01 2 96010558 96010562 5 + 0.422 0.249 -1.084
ENSG00000231584 E012 1.2210915 0.0118175178 3.532042e-01 4.974374e-01 2 96010563 96010563 1 + 0.422 0.249 -1.084
ENSG00000231584 E013 8.0539681 0.0025735658 4.044155e-01 5.481214e-01 2 96010564 96010592 29 + 0.964 0.857 -0.407
ENSG00000231584 E014 9.4534400 0.0021218425 8.811007e-01 9.277819e-01 2 96010593 96010595 3 + 0.964 0.942 -0.085
ENSG00000231584 E015 10.2973045 0.0017541849 7.354106e-01 8.261905e-01 2 96010596 96010601 6 + 1.013 0.969 -0.161
ENSG00000231584 E016 15.4578845 0.0012295082 7.819126e-02 1.565552e-01 2 96010602 96010612 11 + 1.268 1.101 -0.593
ENSG00000231584 E017 28.3649651 0.0007363556 1.456025e-01 2.556793e-01 2 96010613 96010624 12 + 1.469 1.359 -0.380
ENSG00000231584 E018 54.8502500 0.0096858618 3.120145e-01 4.545365e-01 2 96010625 96010722 98 + 1.724 1.648 -0.258
ENSG00000231584 E019 36.0534987 0.0013477632 1.245501e-01 2.264783e-01 2 96010723 96010732 10 + 1.570 1.464 -0.363
ENSG00000231584 E020 1.8027232 0.0080350034 6.381919e-01 7.518813e-01 2 96010733 96010851 119 + 0.321 0.406 0.501
ENSG00000231584 E021 2.3603990 0.0062754687 2.916532e-02 7.031769e-02 2 96013724 96013729 6 + 0.731 0.372 -1.694
ENSG00000231584 E022 6.4232016 0.0542913583 1.524230e-02 4.103522e-02 2 96013730 96013921 192 + 1.077 0.697 -1.461
ENSG00000231584 E023 3.4603650 0.0067062090 8.012363e-02 1.597433e-01 2 96013922 96013971 50 + 0.773 0.496 -1.208
ENSG00000231584 E024 34.0378322 0.0006013738 9.336696e-01 9.622140e-01 2 96015109 96015325 217 + 1.469 1.469 -0.001
ENSG00000231584 E025 26.7639138 0.0113744408 3.336956e-02 7.852048e-02 2 96019201 96019260 60 + 1.508 1.325 -0.631
ENSG00000231584 E026 11.2558788 0.0037629516 1.860697e-01 3.088235e-01 2 96019261 96019274 14 + 1.133 0.987 -0.534
ENSG00000231584 E027 29.3548732 0.0479917494 7.787289e-02 1.560580e-01 2 96019275 96019459 185 + 1.571 1.353 -0.749
ENSG00000231584 E028 14.0935244 0.0149772833 5.556298e-02 1.189446e-01 2 96019460 96019480 21 + 1.268 1.056 -0.756
ENSG00000231584 E029 27.2732606 0.0007758083 1.651854e-02 4.388183e-02 2 96019481 96019537 57 + 1.508 1.333 -0.605
ENSG00000231584 E030 43.2731274 0.0005160926 3.254969e-01 4.689380e-01 2 96019538 96019627 90 + 1.618 1.554 -0.218
ENSG00000231584 E031 49.2140654 0.0004769305 4.054924e-01 5.491723e-01 2 96019628 96019700 73 + 1.662 1.609 -0.178
ENSG00000231584 E032 116.3354856 0.0031781494 5.049475e-01 6.408102e-01 2 96021125 96021195 71 + 1.968 1.993 0.082
ENSG00000231584 E033 105.3520161 0.0003423285 6.694495e-01 7.762591e-01 2 96021196 96021233 38 + 1.936 1.947 0.036
ENSG00000231584 E034 27.7892859 0.0007435546 1.665503e-01 2.837081e-01 2 96021234 96021367 134 + 1.461 1.356 -0.365
ENSG00000231584 E035 125.1022115 0.0003272550 1.999687e-01 3.262160e-01 2 96021368 96021465 98 + 1.988 2.029 0.137
ENSG00000231584 E036 20.8657831 0.0009120684 1.040803e-01 1.967226e-01 2 96021598 96021834 237 + 1.150 1.292 0.500
ENSG00000231584 E037 130.4141512 0.0005322776 7.166702e-01 8.122575e-01 2 96022674 96022753 80 + 2.037 2.044 0.025
ENSG00000231584 E038 135.2453790 0.0002705462 1.024617e-01 1.942641e-01 2 96022754 96022893 140 + 2.014 2.065 0.170
ENSG00000231584 E039 86.4696074 0.0010745716 1.715385e-01 2.902050e-01 2 96022894 96022929 36 + 1.817 1.873 0.190
ENSG00000231584 E040 101.2093413 0.0003187182 8.034506e-02 1.601011e-01 2 96022930 96022991 62 + 1.881 1.946 0.219
ENSG00000231584 E041 151.9886284 0.0003025378 4.287330e-06 3.096183e-05 2 96022992 96023398 407 + 1.986 2.137 0.508