ENSG00000231365

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000425884 ENSG00000231365 HEK293_OSMI2_2hA HEK293_TMG_2hB WARS2-AS1 lncRNA lncRNA 13.30121 12.18832 14.27208 0.7739731 0.09558979 0.2275239 2.4526404 3.6877093 2.8091711 0.1977551 0.51125322 -0.391360743 0.18769583 0.30683333 0.19640000 -0.1104333 2.494461e-01 6.913377e-06   FALSE
ENST00000440150 ENSG00000231365 HEK293_OSMI2_2hA HEK293_TMG_2hB WARS2-AS1 lncRNA lncRNA 13.30121 12.18832 14.27208 0.7739731 0.09558979 0.2275239 1.2634104 2.2868293 0.7375888 0.5391500 0.08274671 -1.619326711 0.09639167 0.18366667 0.05166667 -0.1320000 7.416297e-05 6.913377e-06   FALSE
ENST00000445565 ENSG00000231365 HEK293_OSMI2_2hA HEK293_TMG_2hB WARS2-AS1 lncRNA lncRNA 13.30121 12.18832 14.27208 0.7739731 0.09558979 0.2275239 0.8893367 0.8790826 0.8770927 0.1144787 0.20002570 -0.003232499 0.06583750 0.07196667 0.06126667 -0.0107000 8.132138e-01 6.913377e-06   FALSE
ENST00000670000 ENSG00000231365 HEK293_OSMI2_2hA HEK293_TMG_2hB WARS2-AS1 lncRNA lncRNA 13.30121 12.18832 14.27208 0.7739731 0.09558979 0.2275239 4.5280846 3.0456822 5.8742394 0.1459111 0.14766083 0.945361429 0.33769167 0.25060000 0.41176667 0.1611667 6.913377e-06 6.913377e-06   FALSE
ENST00000688395 ENSG00000231365 HEK293_OSMI2_2hA HEK293_TMG_2hB WARS2-AS1 lncRNA lncRNA 13.30121 12.18832 14.27208 0.7739731 0.09558979 0.2275239 1.7662556 1.6248174 1.3828432 0.2782054 0.58876056 -0.231096642 0.13456667 0.13216667 0.09736667 -0.0348000 6.576384e-01 6.913377e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000231365 E001 0.2987644 0.0273744610 2.498800e-01   1 119140391 119140395 5 + 0.202 0.000 -10.225
ENSG00000231365 E002 4.3447129 0.0582447348 1.778592e-01 2.984516e-01 1 119140396 119140412 17 + 0.599 0.827 0.945
ENSG00000231365 E003 6.2289095 0.0062610393 1.624662e-01 2.783592e-01 1 119140413 119140424 12 + 0.760 0.947 0.724
ENSG00000231365 E004 53.0031381 0.0005986601 1.224750e-01 2.234771e-01 1 119140425 119140535 111 + 1.688 1.775 0.293
ENSG00000231365 E005 84.8038997 0.0030111753 1.948713e-02 5.038596e-02 1 119140536 119140707 172 + 1.873 1.987 0.383
ENSG00000231365 E006 27.3784689 0.0030387484 4.485498e-01 5.898314e-01 1 119140708 119140729 22 + 1.419 1.481 0.216
ENSG00000231365 E007 24.5469509 0.0008352747 2.700198e-01 4.085916e-01 1 119140730 119140740 11 + 1.361 1.449 0.305
ENSG00000231365 E008 25.0966713 0.0008265518 2.690831e-01 4.075518e-01 1 119140741 119140751 11 + 1.372 1.460 0.303
ENSG00000231365 E009 26.9726378 0.0009486808 4.525002e-01 5.933392e-01 1 119140752 119140760 9 + 1.414 1.476 0.214
ENSG00000231365 E010 37.9386619 0.0011478271 9.547122e-01 9.756186e-01 1 119140761 119140793 33 + 1.588 1.597 0.032
ENSG00000231365 E011 6.4029992 0.0101366580 4.717851e-03 1.514475e-02 1 119141747 119141813 67 + 1.021 0.659 -1.416
ENSG00000231365 E012 0.7384352 0.0180696320 2.650351e-02 6.495654e-02 1 119141814 119142200 387 + 0.395 0.000 -13.903
ENSG00000231365 E013 3.7032931 0.0754407802 4.348709e-01 5.771237e-01 1 119146359 119146408 50 + 0.598 0.748 0.635
ENSG00000231365 E014 11.1235663 0.0601507387 6.822833e-01 7.857492e-01 1 119146409 119146641 233 + 1.110 1.065 -0.163
ENSG00000231365 E015 8.7424034 0.0022924141 2.435091e-01 3.782960e-01 1 119146642 119146743 102 + 1.045 0.929 -0.429
ENSG00000231365 E016 9.7730437 0.0017344923 3.610080e-01 5.053823e-01 1 119146744 119146836 93 + 1.078 0.996 -0.300
ENSG00000231365 E017 45.8180720 0.0005420822 5.178447e-01 6.521753e-01 1 119146953 119146973 21 + 1.683 1.662 -0.070
ENSG00000231365 E018 77.6121849 0.0003793040 5.582391e-01 6.865225e-01 1 119146974 119147069 96 + 1.901 1.891 -0.036
ENSG00000231365 E019 78.6185696 0.0004541717 8.433268e-01 9.024325e-01 1 119150565 119150652 88 + 1.898 1.902 0.015
ENSG00000231365 E020 45.9165349 0.0006299958 8.194107e-02 1.626058e-01 1 119150653 119150746 94 + 1.711 1.634 -0.261
ENSG00000231365 E021 10.6551417 0.0930692401 7.517915e-02 1.518208e-01 1 119150747 119150792 46 + 0.908 1.183 1.007
ENSG00000231365 E022 65.2640355 0.0030424124 3.634002e-13 9.547229e-12 1 119150793 119151416 624 + 1.587 1.971 1.295
ENSG00000231365 E023 3.2774380 0.0047299397 3.779688e-03 1.252516e-02 1 119160589 119160591 3 + 0.340 0.803 2.173
ENSG00000231365 E024 32.5263189 0.0055731069 2.357748e-03 8.331810e-03 1 119160592 119161792 1201 + 1.404 1.629 0.771
ENSG00000231365 E025 335.3727430 0.0015637426 1.076973e-22 9.261433e-21 1 119178644 119181389 2746 + 2.625 2.407 -0.727
ENSG00000231365 E026 26.0112973 0.0098851741 1.363100e-01 2.429077e-01 1 119181390 119181426 37 + 1.487 1.376 -0.383
ENSG00000231365 E027 22.3701903 0.0084728074 7.304955e-01 8.224408e-01 1 119181427 119181461 35 + 1.383 1.368 -0.051
ENSG00000231365 E028 89.9973879 0.0005115131 4.352015e-01 5.774452e-01 1 119181462 119181977 516 + 1.967 1.950 -0.057
ENSG00000231365 E029 371.9344301 0.0077769587 5.469815e-03 1.720786e-02 1 119181978 119183933 1956 + 2.510 2.628 0.395
ENSG00000231365 E030 0.9169173 0.0579401019 5.480781e-01 6.779742e-01 1 119231477 119231511 35 + 0.340 0.233 -0.737
ENSG00000231365 E031 5.8387390 0.0028280819 1.806324e-01 3.019746e-01 1 119233458 119234181 724 + 0.910 0.751 -0.619
ENSG00000231365 E032 2.7325059 0.0239163927 2.060657e-02 5.276190e-02 1 119236632 119238057 1426 + 0.712 0.317 -1.949
ENSG00000231365 E033 0.1515154 0.0433749940 5.712864e-01   1 119261447 119261716 270 + 0.113 0.000 -11.369
ENSG00000231365 E034 1.0996659 0.0145808027 5.682080e-01 6.948938e-01 1 119262902 119262944 43 + 0.276 0.385 0.680
ENSG00000231365 E035 6.5343208 0.0025682871 8.893318e-01 9.332642e-01 1 119275188 119275973 786 + 0.877 0.871 -0.023