ENSG00000230606

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000604397 ENSG00000230606 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 6.151773 2.698792 5.519582 0.9159142 0.4949792 1.029521 1.3201189 0.01934025 1.9718595 0.01934025 0.38831184 6.0778295 0.19450833 0.01230000 0.35250000 0.34020000 5.052113e-09 5.052113e-09 TRUE FALSE
ENST00000610408 ENSG00000230606 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 6.151773 2.698792 5.519582 0.9159142 0.4949792 1.029521 0.9398519 0.74761626 0.3587408 0.20723257 0.17977899 -1.0388603 0.16918333 0.30310000 0.06906667 -0.23403333 2.296497e-01 5.052113e-09 TRUE FALSE
ENST00000620051 ENSG00000230606 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 6.151773 2.698792 5.519582 0.9159142 0.4949792 1.029521 0.1629012 0.27205668 0.0000000 0.12320320 0.00000000 -4.8179132 0.03194167 0.09746667 0.00000000 -0.09746667 7.558354e-07 5.052113e-09   FALSE
ENST00000620272 ENSG00000230606 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 6.151773 2.698792 5.519582 0.9159142 0.4949792 1.029521 0.1147782 0.00000000 0.3076433 0.00000000 0.10754590 4.9893356 0.02319583 0.00000000 0.05286667 0.05286667 7.245704e-03 5.052113e-09 TRUE TRUE
ENST00000621982 ENSG00000230606 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 6.151773 2.698792 5.519582 0.9159142 0.4949792 1.029521 0.6191748 0.51338823 0.0000000 0.29409141 0.00000000 -5.7098096 0.10117917 0.16173333 0.00000000 -0.16173333 5.833265e-02 5.052113e-09   FALSE
ENST00000653793 ENSG00000230606 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 6.151773 2.698792 5.519582 0.9159142 0.4949792 1.029521 2.0182591 0.64492009 2.3316678 0.20723278 0.32374822 1.8381456 0.31130417 0.24103333 0.41966667 0.17863333 2.357878e-02 5.052113e-09 TRUE FALSE
ENST00000656384 ENSG00000230606 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 6.151773 2.698792 5.519582 0.9159142 0.4949792 1.029521 0.1840131 0.16632707 0.2027007 0.09382242 0.04735422 0.2705706 0.04100833 0.09076667 0.03583333 -0.05493333 8.321086e-01 5.052113e-09 TRUE FALSE
MSTRG.18904.1 ENSG00000230606 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   6.151773 2.698792 5.519582 0.9159142 0.4949792 1.029521 0.0368707 0.18369777 0.0000000 0.13542656 0.00000000 -4.2757354 0.00888750 0.05493333 0.00000000 -0.05493333 2.903631e-02 5.052113e-09 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000230606 E001 0.0000000       2 97416165 97416220 56 -      
ENSG00000230606 E002 0.0000000       2 97416221 97416223 3 -      
ENSG00000230606 E003 0.0000000       2 97416224 97416254 31 -      
ENSG00000230606 E004 0.0000000       2 97416255 97416263 9 -      
ENSG00000230606 E005 0.1472490 0.446858814 1.000000000   2 97416264 97416405 142 - 0.084 0.000 -9.341
ENSG00000230606 E006 0.1482932 0.047914028 0.119449137   2 97422165 97422438 274 - 0.000 0.175 12.862
ENSG00000230606 E007 0.0000000       2 97422439 97422495 57 -      
ENSG00000230606 E008 0.0000000       2 97422496 97422497 2 -      
ENSG00000230606 E009 0.1451727 0.404937897 1.000000000   2 97422498 97422556 59 - 0.084 0.000 -11.492
ENSG00000230606 E010 0.1451727 0.404937897 1.000000000   2 97422557 97422579 23 - 0.084 0.000 -11.492
ENSG00000230606 E011 0.2934659 0.032118200 0.367120869   2 97422580 97422656 77 - 0.084 0.175 1.220
ENSG00000230606 E012 0.0000000       2 97422657 97422659 3 -      
ENSG00000230606 E013 0.0000000       2 97422660 97422954 295 -      
ENSG00000230606 E014 0.4417591 0.024441170 0.120772173 0.22105667 2 97422955 97423035 81 - 0.084 0.299 2.219
ENSG00000230606 E015 0.8855944 0.016291033 0.036389557 0.08432586 2 97423036 97423058 23 - 0.154 0.474 2.217
ENSG00000230606 E016 0.8855944 0.016291033 0.036389557 0.08432586 2 97423059 97423084 26 - 0.154 0.474 2.217
ENSG00000230606 E017 2.0637124 0.010520042 0.170617258 0.28896135 2 97423177 97423261 85 - 0.432 0.599 0.803
ENSG00000230606 E018 1.7702465 0.009547905 0.234509878 0.36777089 2 97423262 97423272 11 - 0.396 0.541 0.733
ENSG00000230606 E019 0.3030308 0.757407742 1.000000000   2 97423273 97423788 516 - 0.155 0.000 -12.153
ENSG00000230606 E020 0.8877725 0.014865522 0.673591706 0.77923065 2 97423789 97423797 9 - 0.268 0.299 0.220
ENSG00000230606 E021 0.8877725 0.014865522 0.673591706 0.77923065 2 97423798 97423801 4 - 0.268 0.299 0.220
ENSG00000230606 E022 1.8079241 0.008627035 0.225695975 0.35721683 2 97423802 97423918 117 - 0.396 0.542 0.735
ENSG00000230606 E023 0.4782907 0.026829778 0.006906828 0.02098265 2 97423919 97424294 376 - 0.000 0.396 14.129
ENSG00000230606 E024 0.5117019 0.486809051 0.017359182 0.04573343 2 97424295 97424405 111 - 0.000 0.393 13.860
ENSG00000230606 E025 0.4783925 0.031783762 0.691093228 0.79263783 2 97424406 97425470 1065 - 0.154 0.175 0.223
ENSG00000230606 E026 0.0000000       2 97425878 97426842 965 -      
ENSG00000230606 E027 0.0000000       2 97426843 97427127 285 -      
ENSG00000230606 E028 8.3279143 0.667473751 0.211037087 0.33975222 2 97427128 97428263 1136 - 1.084 0.406 -2.847
ENSG00000230606 E029 5.9473731 0.004605801 0.006027112 0.01868250 2 97429217 97429871 655 - 0.938 0.475 -1.948
ENSG00000230606 E030 0.0000000       2 97433300 97433527 228 -