ENSG00000230453

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000605687 ENSG00000230453 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD18B protein_coding protein_coding 3.581543 4.115384 3.614092 0.4289809 0.1299361 -0.1869088 1.12345239 1.6709614 1.34293276 0.1903532 0.14216447 -0.3131965 0.29309583 0.4053000 0.36976667 -0.03553333 7.681406e-01 8.256933e-08 FALSE TRUE
MSTRG.32551.1 ENSG00000230453 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD18B protein_coding   3.581543 4.115384 3.614092 0.4289809 0.1299361 -0.1869088 1.14994135 1.0101179 1.29545640 0.1871566 0.28559352 0.3558184 0.34892083 0.2418333 0.36240000 0.12056667 5.347059e-01 8.256933e-08 TRUE TRUE
MSTRG.32551.4 ENSG00000230453 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD18B protein_coding   3.581543 4.115384 3.614092 0.4289809 0.1299361 -0.1869088 0.43187766 0.2403084 0.63136262 0.1065716 0.41974648 1.3574338 0.13540000 0.0617000 0.17473333 0.11303333 8.532362e-01 8.256933e-08 TRUE TRUE
MSTRG.32551.5 ENSG00000230453 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD18B protein_coding   3.581543 4.115384 3.614092 0.4289809 0.1299361 -0.1869088 0.07053521 0.0000000 0.19264235 0.0000000 0.19264235 4.3408638 0.02400833 0.0000000 0.05096667 0.05096667 7.969856e-01 8.256933e-08 TRUE TRUE
MSTRG.32551.6 ENSG00000230453 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD18B protein_coding   3.581543 4.115384 3.614092 0.4289809 0.1299361 -0.1869088 0.35865613 1.0425361 0.03680071 0.1661618 0.03680071 -4.4911955 0.08707500 0.2526000 0.01096667 -0.24163333 8.256933e-08 8.256933e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000230453 E001 10.4837350 0.0546293040 0.3124267221 0.4549597687 9 33524251 33524393 143 + 1.109 0.981 -0.468
ENSG00000230453 E002 7.7943710 0.0144577620 0.7632016136 0.8466080119 9 33524394 33524445 52 + 0.966 0.922 -0.165
ENSG00000230453 E003 16.3562730 0.0011295080 0.1577263164 0.2720941080 9 33524446 33524493 48 + 1.294 1.172 -0.430
ENSG00000230453 E004 18.8821180 0.0009787483 0.1227058443 0.2238208190 9 33524494 33524534 41 + 1.353 1.229 -0.436
ENSG00000230453 E005 26.5553159 0.0011768298 0.2456572110 0.3808233278 9 33524535 33524634 100 + 1.478 1.396 -0.284
ENSG00000230453 E006 20.7491327 0.0074402903 0.6053916775 0.7257929962 9 33524635 33524695 61 + 1.309 1.346 0.128
ENSG00000230453 E007 0.1515154 0.0430176250 0.4122020443   9 33528632 33528726 95 + 0.133 0.000 -11.263
ENSG00000230453 E008 22.1264799 0.0010871818 0.8087174241 0.8785094751 9 33528727 33528841 115 + 1.346 1.358 0.043
ENSG00000230453 E009 25.2105912 0.0035915619 0.9844109201 0.9943304531 9 33529000 33529173 174 + 1.411 1.406 -0.017
ENSG00000230453 E010 8.8435150 0.0022504542 0.0318941452 0.0756482182 9 33533439 33533441 3 + 1.109 0.874 -0.869
ENSG00000230453 E011 20.3103175 0.0145568860 0.9919689459 0.9990884538 9 33533442 33533545 104 + 1.324 1.322 -0.008
ENSG00000230453 E012 0.2214452 0.0364098309 0.5728831435   9 33533546 33533847 302 + 0.000 0.112 10.074
ENSG00000230453 E013 27.1216171 0.0010357168 0.0150640883 0.0406339802 9 33534370 33534507 138 + 1.332 1.493 0.556
ENSG00000230453 E014 16.3718532 0.0012031437 0.0357034492 0.0830100923 9 33536878 33536886 9 + 1.109 1.285 0.626
ENSG00000230453 E015 19.9814432 0.0009913592 0.0586907949 0.1243880054 9 33536887 33536945 59 + 1.216 1.359 0.500
ENSG00000230453 E016 13.0428440 0.0026562902 0.0425145231 0.0956561621 9 33539449 33539502 54 + 1.014 1.205 0.688
ENSG00000230453 E017 0.0000000       9 33539503 33539558 56 +      
ENSG00000230453 E018 13.6463474 0.0048772890 0.0247100707 0.0612817130 9 33540078 33540212 135 + 1.014 1.229 0.772
ENSG00000230453 E019 5.6565857 0.0167204052 0.0960965319 0.1845152757 9 33541147 33541152 6 + 0.662 0.892 0.921
ENSG00000230453 E020 11.9233871 0.0381809978 0.2353064260 0.3687224550 9 33541153 33541227 75 + 1.014 1.155 0.510
ENSG00000230453 E021 2.3571742 0.0076970327 0.0653809201 0.1356754535 9 33543182 33543184 3 + 0.318 0.627 1.589
ENSG00000230453 E022 17.9069790 0.0024095237 0.2543401777 0.3910085502 9 33543185 33543255 71 + 1.216 1.304 0.311
ENSG00000230453 E023 104.8815870 0.0003119541 0.0621238462 0.1302144906 9 33547938 33548831 894 + 1.977 2.032 0.185
ENSG00000230453 E024 6.8494613 0.0026048805 0.0115900385 0.0325602140 9 33548832 33548855 24 + 0.662 0.980 1.253
ENSG00000230453 E025 15.3809682 0.0012647127 0.0722047732 0.1470099054 9 33550430 33550579 150 + 1.097 1.251 0.550
ENSG00000230453 E026 14.5779967 0.0034345546 0.6857220972 0.7883719336 9 33555708 33555820 113 + 1.197 1.155 -0.147
ENSG00000230453 E027 15.5230387 0.0012630151 0.9642963464 0.9814967733 9 33558058 33558187 130 + 1.206 1.197 -0.032
ENSG00000230453 E028 25.1447003 0.0061528521 0.9706109724 0.9856363771 9 33566219 33566500 282 + 1.405 1.403 -0.009
ENSG00000230453 E029 0.1482932 0.0418054837 0.5740523074   9 33566972 33567102 131 + 0.000 0.112 10.044
ENSG00000230453 E030 18.2681800 0.0172063068 0.3768051357 0.5211163533 9 33567103 33567314 212 + 1.332 1.236 -0.335
ENSG00000230453 E031 19.1131053 0.0299196540 0.0568510517 0.1212048299 9 33568671 33568893 223 + 1.399 1.190 -0.735
ENSG00000230453 E032 0.0000000       9 33568894 33569126 233 +      
ENSG00000230453 E033 6.2514416 0.0029781296 0.0030234602 0.0103351701 9 33571246 33571291 46 + 1.029 0.657 -1.454
ENSG00000230453 E034 0.0000000       9 33571292 33572315 1024 +      
ENSG00000230453 E035 6.4268058 0.0027464107 0.0001003494 0.0005234853 9 33572316 33572369 54 + 1.084 0.597 -1.916
ENSG00000230453 E036 0.4407149 0.0213851223 0.4654801217 0.6051899888 9 33572370 33573013 644 + 0.235 0.112 -1.286
ENSG00000230453 E037 2.4442368 0.0909343550 0.0201793180 0.0518585862 9 33573196 33573198 3 + 0.725 0.279 -2.259
ENSG00000230453 E038 6.9889423 0.0452350653 0.0530834919 0.1146315162 9 33573199 33573287 89 + 1.030 0.741 -1.106
ENSG00000230453 E039 2.4293838 0.0064516380 0.8492407673 0.9064204029 9 33574840 33574842 3 + 0.499 0.527 0.132
ENSG00000230453 E040 7.7147186 0.0021569955 0.0033204915 0.0112069473 9 33574843 33575015 173 + 1.097 0.757 -1.284
ENSG00000230453 E041 11.1027508 0.0018505466 0.0024431673 0.0085916749 9 33575169 33575423 255 + 1.225 0.923 -1.100