ENSG00000229931

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000450930 ENSG00000229931 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.8642014 0.4502516 0.6330542 0.08910462 0.01797565 0.4825178 0.454825774 0.21498595 0.34337904 0.11246612 0.18050225 0.6513816 0.53607083 0.3994000 0.5588000 0.1594000 0.8890994 0.040436   FALSE
ENST00000689080 ENSG00000229931 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.8642014 0.4502516 0.6330542 0.08910462 0.01797565 0.4825178 0.043863334 0.01637304 0.19560976 0.01637304 0.15781309 2.9627729 0.05857500 0.0579000 0.2956667 0.2377667 0.7245813 0.040436 FALSE FALSE
ENST00000691630 ENSG00000229931 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.8642014 0.4502516 0.6330542 0.08910462 0.01797565 0.4825178 0.009732912 0.07786330 0.00000000 0.07786330 0.00000000 -3.1352606 0.03442917 0.2754333 0.0000000 -0.2754333 0.7925977 0.040436   FALSE
ENST00000692714 ENSG00000229931 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.8642014 0.4502516 0.6330542 0.08910462 0.01797565 0.4825178 0.017628662 0.14102929 0.00000000 0.07056668 0.00000000 -3.9167565 0.03340833 0.2672667 0.0000000 -0.2672667 0.0404360 0.040436   FALSE
ENST00000693115 ENSG00000229931 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.8642014 0.4502516 0.6330542 0.08910462 0.01797565 0.4825178 0.313581811 0.00000000 0.09406545 0.00000000 0.04839244 3.3794192 0.30151667 0.0000000 0.1455333 0.1455333 0.2596675 0.040436   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000229931 E001 0.2955422 0.029413297 0.76805982   6 16761138 16761166 29 + 0.109 0.137 0.387
ENSG00000229931 E002 0.5933762 0.047960929 0.09242464 0.17890276 6 16761724 16761746 23 + 0.330 0.000 -12.491
ENSG00000229931 E003 0.7750806 0.045293984 0.35667480 0.50104903 6 16761747 16761771 25 + 0.330 0.138 -1.610
ENSG00000229931 E004 0.9223296 0.014687561 0.21841756 0.34850085 6 16761772 16761868 97 + 0.384 0.138 -1.933
ENSG00000229931 E005 0.1472490 0.045105576 0.72268478   6 16761869 16761879 11 + 0.109 0.000 -10.976
ENSG00000229931 E006 0.2987644 0.029078516 0.34184658   6 16761903 16761911 9 + 0.196 0.000 -11.789
ENSG00000229931 E007 0.8856842 0.017991020 0.02649428 0.06493729 6 16761912 16761937 26 + 0.432 0.000 -12.890
ENSG00000229931 E008 1.0329332 0.020275924 0.01519601 0.04093144 6 16761938 16761963 26 + 0.476 0.000 -13.025
ENSG00000229931 E009 1.5478443 0.011890694 0.17437566 0.29386861 6 16761964 16761967 4 + 0.515 0.242 -1.610
ENSG00000229931 E010 3.3086381 0.008553368 0.79213736 0.86706133 6 16761968 16762118 151 + 0.645 0.638 -0.027
ENSG00000229931 E011 5.3109495 0.003631242 0.07651182 0.15391653 6 16762119 16762279 161 + 0.721 0.886 0.651
ENSG00000229931 E012 1.3995737 0.011000873 0.04384113 0.09809691 6 16762280 16762351 72 + 0.196 0.510 1.975
ENSG00000229931 E013 22.3294902 0.002706566 0.29441112 0.43551319 6 16762352 16763947 1596 + 1.365 1.361 -0.013