ENSG00000229404

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000415469 ENSG00000229404 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00858 lncRNA lncRNA 0.7252099 0.8064287 0.8258419 0.1380759 0.06490157 0.03390308 0.17484572 0.14683449 0.26616541 0.02297288 0.06062237 0.8162897 0.25737083 0.19943333 0.3323333 0.1329000 0.53230837 0.01055537 FALSE FALSE
ENST00000437892 ENSG00000229404 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00858 lncRNA lncRNA 0.7252099 0.8064287 0.8258419 0.1380759 0.06490157 0.03390308 0.03849385 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.05107917 0.00000000 0.0000000 0.0000000   0.01055537   FALSE
ENST00000653603 ENSG00000229404 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00858 lncRNA lncRNA 0.7252099 0.8064287 0.8258419 0.1380759 0.06490157 0.03390308 0.16277227 0.23640571 0.39047384 0.14614394 0.05366229 0.7006723 0.22955833 0.25640000 0.4681000 0.2117000 0.52860619 0.01055537   FALSE
ENST00000661042 ENSG00000229404 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00858 lncRNA lncRNA 0.7252099 0.8064287 0.8258419 0.1380759 0.06490157 0.03390308 0.08672178 0.05407607 0.13308444 0.03219778 0.08813474 1.1590092 0.11785000 0.07053333 0.1478333 0.0773000 0.86075396 0.01055537   FALSE
ENST00000661556 ENSG00000229404 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00858 lncRNA lncRNA 0.7252099 0.8064287 0.8258419 0.1380759 0.06490157 0.03390308 0.05507659 0.00000000 0.03611819 0.00000000 0.03611819 2.2053359 0.07385000 0.00000000 0.0517000 0.0517000 0.80567424 0.01055537 FALSE FALSE
ENST00000661758 ENSG00000229404 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00858 lncRNA lncRNA 0.7252099 0.8064287 0.8258419 0.1380759 0.06490157 0.03390308 0.03306360 0.11444204 0.00000000 0.11444204 0.00000000 -3.6374020 0.04090417 0.10573333 0.0000000 -0.1057333 0.72016317 0.01055537 FALSE FALSE
ENST00000663433 ENSG00000229404 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00858 lncRNA lncRNA 0.7252099 0.8064287 0.8258419 0.1380759 0.06490157 0.03390308 0.04401225 0.16319105 0.00000000 0.04515056 0.00000000 -4.1142925 0.06278750 0.22933333 0.0000000 -0.2293333 0.01055537 0.01055537 FALSE FALSE
ENST00000669640 ENSG00000229404 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00858 lncRNA lncRNA 0.7252099 0.8064287 0.8258419 0.1380759 0.06490157 0.03390308 0.11806933 0.09147937 0.00000000 0.09147937 0.00000000 -3.3431146 0.15325417 0.13856667 0.0000000 -0.1385667 0.79568375 0.01055537   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000229404 E001 0.0000000       10 84267747 84267825 79 +      
ENSG00000229404 E002 0.7437457 0.016512484 0.18610816 0.30886566 10 84279968 84279979 12 + 0.359 0.123 -1.969
ENSG00000229404 E003 1.0340911 0.012473458 0.05616351 0.11999130 10 84279980 84279990 11 + 0.467 0.123 -2.553
ENSG00000229404 E004 1.0340911 0.012473458 0.05616351 0.11999130 10 84279991 84279992 2 + 0.467 0.123 -2.553
ENSG00000229404 E005 1.1813402 0.010860850 0.03019469 0.07235017 10 84279993 84279996 4 + 0.512 0.124 -2.775
ENSG00000229404 E006 2.3198164 0.007243862 0.08252266 0.16348766 10 84279997 84280065 69 + 0.657 0.365 -1.427
ENSG00000229404 E007 1.0621020 0.241118121 0.68045479 0.78433014 10 84280066 84280109 44 + 0.293 0.357 0.410
ENSG00000229404 E008 4.1716591 0.006487750 0.40199214 0.54569965 10 84288224 84288311 88 + 0.789 0.664 -0.511
ENSG00000229404 E009 3.8739242 0.004767212 0.59071723 0.71354540 10 84288312 84288420 109 + 0.657 0.722 0.273
ENSG00000229404 E010 4.2257946 0.004188503 0.79000908 0.86567518 10 84288594 84288671 78 + 0.741 0.695 -0.189
ENSG00000229404 E011 2.2768519 0.007243862 0.65897062 0.76792485 10 84288672 84288696 25 + 0.553 0.474 -0.382
ENSG00000229404 E012 1.8308384 0.009433345 0.69985766 0.79946606 10 84288697 84288780 84 + 0.416 0.474 0.297
ENSG00000229404 E013 0.0000000       10 84288781 84288816 36 +      
ENSG00000229404 E014 1.6919954 0.008521399 0.47426492 0.61311324 10 84288817 84288974 158 + 0.359 0.474 0.618
ENSG00000229404 E015 1.9950262 0.008133366 0.92897975 0.95934296 10 84288975 84288995 21 + 0.467 0.474 0.033
ENSG00000229404 E016 3.6076286 0.004826734 0.76149229 0.84534546 10 84288996 84289044 49 + 0.687 0.633 -0.230
ENSG00000229404 E017 0.5848434 0.020952051 0.04211128 0.09492701 10 84289045 84289468 424 + 0.359 0.000 -11.860
ENSG00000229404 E018 5.0427043 0.003815136 0.97162802 0.98626739 10 84289519 84289661 143 + 0.789 0.774 -0.060
ENSG00000229404 E019 6.3459186 0.010989945 0.61302197 0.73183072 10 84289662 84289745 84 + 0.832 0.881 0.189
ENSG00000229404 E020 7.3349426 0.058024577 0.56423131 0.69155877 10 84289746 84289880 135 + 0.888 0.937 0.184
ENSG00000229404 E021 5.0954679 0.113464000 0.80071414 0.87297725 10 84289881 84290616 736 + 0.764 0.799 0.138
ENSG00000229404 E022 0.0000000       10 84290617 84290619 3 +      
ENSG00000229404 E023 5.2098618 0.107901456 0.39259819 0.53655297 10 84291407 84292047 641 + 0.872 0.699 -0.687
ENSG00000229404 E024 2.1486180 0.009879887 0.85094554 0.90757714 10 84292048 84292137 90 + 0.512 0.474 -0.189
ENSG00000229404 E025 2.0377858 0.063016158 0.09471858 0.18245753 10 84292192 84292378 187 + 0.294 0.597 1.612
ENSG00000229404 E026 10.0965172 0.003079983 0.21210883 0.34101976 10 84293246 84293925 680 + 0.986 1.097 0.406
ENSG00000229404 E027 4.8232166 0.003625184 0.01351021 0.03710019 10 84293926 84294290 365 + 0.553 0.880 1.355
ENSG00000229404 E028 2.4065077 0.033233177 0.42797250 0.57077964 10 84294291 84294656 366 + 0.467 0.596 0.609
ENSG00000229404 E029 0.1472490 0.045237534 0.51264379   10 84294657 84294657 1 + 0.121 0.000 -9.861
ENSG00000229404 E030 0.1472490 0.045237534 0.51264379   10 84294658 84294659 2 + 0.121 0.000 -9.861