ENSG00000228801

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000518942 ENSG00000228801 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD1-DT lncRNA lncRNA 4.003369 5.53647 2.784541 0.2620786 0.3187843 -0.9889586 0.2285012 0.1906775 0.4279300 0.13983920 0.24125576 1.1258211 0.07144583 0.03243333 0.1497667 0.1173333 0.23578723 0.01545281 FALSE TRUE
ENST00000521612 ENSG00000228801 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD1-DT lncRNA lncRNA 4.003369 5.53647 2.784541 0.2620786 0.3187843 -0.9889586 0.9036840 1.7118398 0.4869458 0.05020606 0.08332545 -1.7927905 0.20657500 0.30996667 0.1734667 -0.1365000 0.01545281 0.01545281   FALSE
ENST00000656129 ENSG00000228801 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD1-DT lncRNA lncRNA 4.003369 5.53647 2.784541 0.2620786 0.3187843 -0.9889586 0.7661967 0.6195390 1.1122721 0.20974517 0.13117965 0.8340549 0.21936667 0.11516667 0.4069000 0.2917333 0.01817790 0.01545281 FALSE FALSE
ENST00000684825 ENSG00000228801 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD1-DT lncRNA lncRNA 4.003369 5.53647 2.784541 0.2620786 0.3187843 -0.9889586 1.6414214 2.9735754 0.2554715 0.31242112 0.25547147 -3.4904135 0.39437500 0.53496667 0.0823000 -0.4526667 0.04503946 0.01545281   FALSE
ENST00000686509 ENSG00000228801 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD1-DT lncRNA lncRNA 4.003369 5.53647 2.784541 0.2620786 0.3187843 -0.9889586 0.4166960 0.0000000 0.5019214 0.00000000 0.27954776 5.6778504 0.09788750 0.00000000 0.1875667 0.1875667 0.13189333 0.01545281   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000228801 E001 3.456980 0.0956081477 3.184131e-01 4.613935e-01 8 51899268 51899282 15 + 0.537 0.687 0.661
ENSG00000228801 E002 5.004834 0.0037332111 7.306713e-02 1.484402e-01 8 51899283 51899314 32 + 0.629 0.828 0.816
ENSG00000228801 E003 7.356839 0.0565238154 2.234039e-01 3.544596e-01 8 51899315 51899324 10 + 0.825 0.952 0.482
ENSG00000228801 E004 35.564440 0.0006124899 8.457378e-04 3.422514e-03 8 51899325 51899648 324 + 1.451 1.583 0.451
ENSG00000228801 E005 19.576412 0.0234921672 3.147848e-02 7.484254e-02 8 51899649 51899714 66 + 1.159 1.336 0.626
ENSG00000228801 E006 15.201798 0.0058841514 7.045724e-04 2.915346e-03 8 51899715 51899733 19 + 0.979 1.255 0.994
ENSG00000228801 E007 28.022381 0.0026118841 2.207656e-03 7.865972e-03 8 51899734 51899846 113 + 1.329 1.481 0.525
ENSG00000228801 E008 21.753642 0.0010008185 1.608867e-07 1.571108e-06 8 51899847 51900207 361 + 1.063 1.428 1.287
ENSG00000228801 E009 3.350387 0.0049145091 9.283929e-06 6.216862e-05 8 51900208 51900287 80 + 0.000 0.774 12.496
ENSG00000228801 E010 8.036851 0.0022472548 6.874585e-04 2.853508e-03 8 51911420 51911729 310 + 0.668 1.037 1.435
ENSG00000228801 E011 3.224134 0.3445912174 3.902259e-01 5.342182e-01 8 51913057 51913180 124 + 0.795 0.458 -1.487
ENSG00000228801 E012 103.878857 0.0070360525 1.063050e-22 9.145851e-21 8 51946436 51949874 3439 + 2.219 1.820 -1.339