ENSG00000228794

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000445118 ENSG00000228794 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01128 lncRNA lncRNA 10.15851 9.547416 12.42996 0.6507492 0.5480479 0.380289 3.2493860 2.6594587 4.8470426 0.07065300 0.11445896 0.86353088 0.3167917 0.28030000 0.39143333 0.111133333 0.02540823 0.02540823 FALSE FALSE
ENST00000610067 ENSG00000228794 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01128 lncRNA lncRNA 10.15851 9.547416 12.42996 0.6507492 0.5480479 0.380289 0.6318535 0.4474764 0.6713684 0.02094754 0.05520992 0.57473790 0.0628000 0.04743333 0.05390000 0.006466667 0.85173617 0.02540823   FALSE
ENST00000661237 ENSG00000228794 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01128 lncRNA lncRNA 10.15851 9.547416 12.42996 0.6507492 0.5480479 0.380289 0.8822985 1.1181135 1.0982356 0.32576132 0.47048341 -0.02564767 0.0878625 0.11733333 0.08586667 -0.031466667 0.74725112 0.02540823   FALSE
ENST00000667414 ENSG00000228794 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01128 lncRNA lncRNA 10.15851 9.547416 12.42996 0.6507492 0.5480479 0.380289 0.5400424 0.2732218 0.6580477 0.05451448 0.04231881 1.23801864 0.0533500 0.02883333 0.05303333 0.024200000 0.15230221 0.02540823   FALSE
ENST00000691234 ENSG00000228794 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01128 lncRNA lncRNA 10.15851 9.547416 12.42996 0.6507492 0.5480479 0.380289 0.2336868 0.6041669 0.0000000 0.31803985 0.00000000 -5.94055888 0.0238125 0.06406667 0.00000000 -0.064066667 0.11422249 0.02540823   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000228794 E001 0.0000000       1 811913 811924 12 +      
ENSG00000228794 E002 0.0000000       1 825138 825552 415 +      
ENSG00000228794 E003 0.3332198 0.0284449382 9.474483e-01   1 826476 826831 356 + 0.118 0.126 0.108
ENSG00000228794 E004 2.3520777 0.0117744003 1.247397e-01 2.267650e-01 1 826832 826852 21 + 0.353 0.607 1.282
ENSG00000228794 E005 4.4439779 0.0835303343 7.949476e-01 8.690299e-01 1 826853 826923 71 + 0.705 0.740 0.144
ENSG00000228794 E006 0.0000000       1 827598 827602 5 +      
ENSG00000228794 E007 0.0000000       1 827603 827603 1 +      
ENSG00000228794 E008 0.0000000       1 827604 827607 4 +      
ENSG00000228794 E009 1.9573366 0.0086973963 3.220087e-01 4.652749e-01 1 827608 827634 27 + 0.545 0.372 -0.891
ENSG00000228794 E010 2.5077352 0.0080303718 5.586892e-01 6.868923e-01 1 827635 827637 3 + 0.582 0.481 -0.475
ENSG00000228794 E011 2.8409550 0.0325688106 6.354089e-01 7.497207e-01 1 827638 827642 5 + 0.617 0.529 -0.399
ENSG00000228794 E012 3.9607819 0.0217125777 5.935708e-01 7.159515e-01 1 827643 827651 9 + 0.732 0.642 -0.374
ENSG00000228794 E013 4.7723666 0.0878954802 9.706945e-01 9.856895e-01 1 827652 827653 2 + 0.757 0.740 -0.067
ENSG00000228794 E014 4.7723666 0.0878954802 9.706945e-01 9.856895e-01 1 827654 827656 3 + 0.757 0.740 -0.067
ENSG00000228794 E015 6.3266502 0.1800960647 7.395475e-01 8.292104e-01 1 827657 827658 2 + 0.803 0.893 0.349
ENSG00000228794 E016 6.8352317 0.0967287609 6.055562e-01 7.259111e-01 1 827659 827660 2 + 0.823 0.924 0.387
ENSG00000228794 E017 7.4264153 0.1066184918 4.505999e-01 5.916812e-01 1 827661 827662 2 + 0.823 0.978 0.587
ENSG00000228794 E018 7.4264153 0.1066184918 4.505999e-01 5.916812e-01 1 827663 827666 4 + 0.823 0.978 0.587
ENSG00000228794 E019 8.8991304 0.0769665799 6.697648e-01 7.764250e-01 1 827667 827672 6 + 0.931 1.021 0.336
ENSG00000228794 E020 30.1769659 0.0372303862 6.751887e-01 7.805253e-01 1 827673 827691 19 + 1.456 1.511 0.188
ENSG00000228794 E021 30.2511621 0.0384244366 6.285876e-01 7.441165e-01 1 827692 827692 1 + 1.451 1.516 0.222
ENSG00000228794 E022 60.7272308 0.0044055093 2.054825e-02 5.264672e-02 1 827693 827770 78 + 1.714 1.835 0.409
ENSG00000228794 E023 45.8196541 0.0005431075 2.474346e-03 8.686715e-03 1 827771 827773 3 + 1.576 1.728 0.514
ENSG00000228794 E024 44.3146486 0.0005551592 4.119168e-03 1.347616e-02 1 827774 827775 2 + 1.565 1.711 0.495
ENSG00000228794 E025 1.3200920 0.0920888146 1.680495e-01 2.856660e-01 1 827776 827805 30 + 0.211 0.479 1.685
ENSG00000228794 E026 1.1717988 0.1790593940 3.254740e-01 4.689157e-01 1 827806 827814 9 + 0.211 0.429 1.427
ENSG00000228794 E027 1.1717988 0.1790593940 3.254740e-01 4.689157e-01 1 827815 827820 6 + 0.211 0.429 1.427
ENSG00000228794 E028 1.3932440 0.0464706371 1.385755e-01 2.461230e-01 1 827821 827849 29 + 0.211 0.482 1.697
ENSG00000228794 E029 0.4783925 0.0223259621 6.210382e-01 7.380626e-01 1 827850 827853 4 + 0.211 0.126 -0.892
ENSG00000228794 E030 0.0000000       1 827854 828127 274 +      
ENSG00000228794 E031 88.8661542 0.0003357253 7.040185e-04 2.913436e-03 1 829003 829104 102 + 1.880 2.000 0.402
ENSG00000228794 E032 0.4470576 0.0227900449 6.208413e-01 7.379027e-01 1 829105 829407 303 + 0.211 0.126 -0.894
ENSG00000228794 E033 0.0000000       1 831578 831604 27 +      
ENSG00000228794 E034 0.0000000       1 831605 831616 12 +      
ENSG00000228794 E035 0.3299976 0.0277775323 1.767431e-01   1 831617 831677 61 + 0.000 0.224 9.402
ENSG00000228794 E036 39.5310094 0.0038476460 8.225321e-01 8.881063e-01 1 841200 841373 174 + 1.604 1.611 0.025
ENSG00000228794 E037 122.3077195 0.0130818580 7.264176e-01 8.194328e-01 1 841374 844498 3125 + 2.082 2.100 0.062
ENSG00000228794 E038 17.5726850 0.0010763546 2.415583e-03 8.508254e-03 1 844499 846365 1867 + 1.384 1.130 -0.892
ENSG00000228794 E039 61.6138051 0.0009703146 6.538660e-01 7.642258e-01 1 847654 847806 153 + 1.789 1.803 0.046
ENSG00000228794 E040 14.4867878 0.0031370717 6.738639e-03 2.054484e-02 1 847807 849162 1356 + 1.310 1.059 -0.894
ENSG00000228794 E041 15.8997211 0.0024720960 1.902857e-01 3.141420e-01 1 849484 849602 119 + 1.290 1.171 -0.418
ENSG00000228794 E042 8.4899595 0.0340743528 5.433858e-01 6.740139e-01 1 849603 850177 575 + 1.030 0.940 -0.333
ENSG00000228794 E043 2.6527070 0.1702716465 8.362907e-01 8.976259e-01 1 850178 850180 3 + 0.616 0.522 -0.430
ENSG00000228794 E044 8.7011492 0.0262971692 3.566187e-01 5.010057e-01 1 850181 850351 171 + 1.055 0.924 -0.483
ENSG00000228794 E045 5.9076602 0.0028160684 7.898593e-01 8.655678e-01 1 850352 851125 774 + 0.822 0.850 0.108
ENSG00000228794 E046 1.7327829 0.0080625120 4.522733e-01 5.931502e-01 1 851348 851926 579 + 0.504 0.371 -0.700
ENSG00000228794 E047 77.8269924 0.0003896455 1.267814e-02 3.515258e-02 1 851927 852014 88 + 1.843 1.935 0.311
ENSG00000228794 E048 74.2868004 0.0003639582 1.084852e-03 4.252295e-03 1 852015 852094 80 + 1.802 1.928 0.426
ENSG00000228794 E049 41.5932491 0.0005732562 6.663889e-03 2.034816e-02 1 852095 852110 16 + 1.546 1.687 0.479
ENSG00000228794 E050 2.3398888 0.0604572656 3.207968e-01 4.639590e-01 1 852111 852233 123 + 0.617 0.428 -0.902
ENSG00000228794 E051 3.6683616 0.0049581238 4.133631e-01 5.568661e-01 1 852234 852650 417 + 0.732 0.606 -0.530
ENSG00000228794 E052 1.3503591 0.1651983547 2.206291e-01 3.511769e-01 1 852651 852670 20 + 0.503 0.223 -1.704
ENSG00000228794 E053 64.0061814 0.0014603559 3.001558e-03 1.026920e-02 1 852671 852766 96 + 1.730 1.862 0.448
ENSG00000228794 E054 2.9370480 0.1802832393 8.277723e-01 8.917278e-01 1 852767 853390 624 + 0.545 0.618 0.327
ENSG00000228794 E055 230.6605263 0.0004453374 1.968833e-01 3.223396e-01 1 853391 854922 1532 + 2.349 2.372 0.078
ENSG00000228794 E056 50.6838490 0.0005544534 1.253941e-03 4.822969e-03 1 854923 855121 199 + 1.791 1.626 -0.561
ENSG00000228794 E057 18.0573174 0.0240988775 2.454606e-02 6.094230e-02 1 855122 855136 15 + 1.400 1.148 -0.886
ENSG00000228794 E058 169.4320229 0.0002630069 1.216648e-16 5.174906e-15 1 855137 856448 1312 + 2.336 2.108 -0.762
ENSG00000228794 E059 261.8891078 0.0068187466 3.091161e-02 7.374418e-02 1 856449 859446 2998 + 2.464 2.375 -0.296