ENSG00000228705

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000412500 ENSG00000228705 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00659 lncRNA lncRNA 0.3512147 0.6218254 0.3056255 0.02471264 0.01878693 -1.001312 0.04638149 0.13557780 0.09092197 0.13557780 0.058538989 -0.5285501 0.12222917 0.2021333 0.27663333 0.07450000 0.6964461 0.0324758   FALSE
ENST00000655940 ENSG00000228705 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00659 lncRNA lncRNA 0.3512147 0.6218254 0.3056255 0.02471264 0.01878693 -1.001312 0.02501599 0.00000000 0.07056365 0.00000000 0.070563654 3.0101291 0.07060417 0.0000000 0.25453333 0.25453333 0.7480066 0.0324758   FALSE
ENST00000658688 ENSG00000228705 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00659 lncRNA lncRNA 0.3512147 0.6218254 0.3056255 0.02471264 0.01878693 -1.001312 0.06093565 0.11237704 0.00000000 0.05687336 0.000000000 -3.6132610 0.17607917 0.1777333 0.00000000 -0.17773333 0.3428251 0.0324758   FALSE
ENST00000658884 ENSG00000228705 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00659 lncRNA lncRNA 0.3512147 0.6218254 0.3056255 0.02471264 0.01878693 -1.001312 0.10161976 0.27749313 0.03241933 0.13932350 0.032419328 -2.7607338 0.21702917 0.4648333 0.10860000 -0.35623333 0.5460423 0.0324758   FALSE
ENST00000667589 ENSG00000228705 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00659 lncRNA lncRNA 0.3512147 0.6218254 0.3056255 0.02471264 0.01878693 -1.001312 0.05298057 0.08257342 0.02902813 0.04835899 0.014911611 -1.2460837 0.13678333 0.1324000 0.09033333 -0.04206667 0.9204254 0.0324758   FALSE
ENST00000689171 ENSG00000228705 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00659 lncRNA lncRNA 0.3512147 0.6218254 0.3056255 0.02471264 0.01878693 -1.001312 0.05202394 0.01380402 0.08269241 0.01380402 0.008578103 1.9612461 0.22225417 0.0229000 0.26986667 0.24696667 0.0324758 0.0324758 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000228705 E001 1.3296333 0.011090576 0.006649607 0.02031524 20 62772980 62774120 1141 - 0.611 0.170 -2.680
ENSG00000228705 E002 0.0000000       20 62774121 62774122 2 -      
ENSG00000228705 E003 0.0000000       20 62774123 62774127 5 -      
ENSG00000228705 E004 5.7924599 0.003115317 0.987241330 0.99608504 20 62774128 62774565 438 - 0.798 0.815 0.067
ENSG00000228705 E005 2.6476214 0.006975547 0.423154963 0.56626807 20 62774566 62774569 4 - 0.611 0.500 -0.508
ENSG00000228705 E006 3.8235597 0.005117639 0.619375938 0.73681743 20 62775315 62775479 165 - 0.696 0.640 -0.234
ENSG00000228705 E007 1.7640015 0.010642181 0.753915649 0.83967512 20 62775480 62775520 41 - 0.366 0.429 0.353
ENSG00000228705 E008 1.3297180 0.036658323 0.659971859 0.76869989 20 62775521 62775702 182 - 0.366 0.295 -0.441
ENSG00000228705 E009 0.5138669 0.023183434 0.260806663 0.39838932 20 62776312 62776455 144 - 0.274 0.094 -1.868
ENSG00000228705 E010 2.1851340 0.011480763 0.161236683 0.27670308 20 62776456 62776795 340 - 0.274 0.533 1.453
ENSG00000228705 E011 1.1510600 0.014223487 0.743288889 0.83195780 20 62776796 62776805 10 - 0.274 0.343 0.449
ENSG00000228705 E012 2.6861407 0.051640907 0.409251964 0.55284909 20 62776806 62776921 116 - 0.441 0.588 0.708
ENSG00000228705 E013 0.7780993 0.018889339 0.484838159 0.62277867 20 62776922 62776932 11 - 0.158 0.292 1.124
ENSG00000228705 E014 0.7780993 0.018889339 0.484838159 0.62277867 20 62776933 62776947 15 - 0.158 0.292 1.124
ENSG00000228705 E015 0.2965864 0.045447246 0.443199644   20 62776948 62776956 9 - 0.000 0.170 10.490
ENSG00000228705 E016 0.2965864 0.045447246 0.443199644   20 62776957 62776966 10 - 0.000 0.170 10.490
ENSG00000228705 E017 0.2965864 0.045447246 0.443199644   20 62776967 62776982 16 - 0.000 0.170 10.490
ENSG00000228705 E018 0.0000000       20 62776983 62776996 14 -