ENSG00000228486

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000596740 ENSG00000228486 HEK293_OSMI2_2hA HEK293_TMG_2hB C2orf92 protein_coding processed_transcript 3.085549 2.28358 3.503737 0.3742948 0.7012081 0.615405 0.08641324 0.37631472 0.0000000 0.18824888 0.00000000 -5.2717048 0.04320833 0.19760000 0.00000000 -0.19760000 0.139160295 0.007644904    
ENST00000608777 ENSG00000228486 HEK293_OSMI2_2hA HEK293_TMG_2hB C2orf92 protein_coding processed_transcript 3.085549 2.28358 3.503737 0.3742948 0.7012081 0.615405 0.16049604 0.15345685 0.1372678 0.11442209 0.04314527 -0.1504674 0.05097083 0.07243333 0.03870000 -0.03373333 0.939792386 0.007644904 FALSE  
ENST00000609004 ENSG00000228486 HEK293_OSMI2_2hA HEK293_TMG_2hB C2orf92 protein_coding processed_transcript 3.085549 2.28358 3.503737 0.3742948 0.7012081 0.615405 0.26419634 0.10890011 0.3631169 0.06263190 0.02414836 1.6498774 0.08914167 0.04176667 0.10996667 0.06820000 0.191538883 0.007644904    
ENST00000615201 ENSG00000228486 HEK293_OSMI2_2hA HEK293_TMG_2hB C2orf92 protein_coding retained_intron 3.085549 2.28358 3.503737 0.3742948 0.7012081 0.615405 0.52789864 0.20282923 0.8115489 0.20282923 0.34778101 1.9486501 0.17085833 0.06746667 0.22146667 0.15400000 0.255206800 0.007644904    
ENST00000628434 ENSG00000228486 HEK293_OSMI2_2hA HEK293_TMG_2hB C2orf92 protein_coding processed_transcript 3.085549 2.28358 3.503737 0.3742948 0.7012081 0.615405 0.41918838 0.22660932 0.5995174 0.22660932 0.43280134 1.3651606 0.09709167 0.07536667 0.13620000 0.06083333 0.709899681 0.007644904    
ENST00000631224 ENSG00000228486 HEK293_OSMI2_2hA HEK293_TMG_2hB C2orf92 protein_coding processed_transcript 3.085549 2.28358 3.503737 0.3742948 0.7012081 0.615405 0.18314790 0.07262988 0.2667680 0.04316968 0.04747188 1.7439416 0.05767500 0.03686667 0.07970000 0.04283333 0.364769671 0.007644904    
MSTRG.18911.1 ENSG00000228486 HEK293_OSMI2_2hA HEK293_TMG_2hB C2orf92 protein_coding   3.085549 2.28358 3.503737 0.3742948 0.7012081 0.615405 0.08613103 0.00000000 0.1923652 0.00000000 0.03157359 4.3388896 0.02487917 0.00000000 0.06256667 0.06256667 0.007644904 0.007644904    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000228486 E001 0.1515154 0.041602897 0.6224928281   2 97664217 97664238 22 + 0.108 0.000 -10.567
ENSG00000228486 E002 0.1515154 0.041602897 0.6224928281   2 97664239 97664246 8 + 0.108 0.000 -13.546
ENSG00000228486 E003 0.5964967 0.020919832 0.4528490974 0.593655263 2 97664247 97664260 14 + 0.266 0.138 -1.176
ENSG00000228486 E004 0.6266857 0.018424116 0.7903869815 0.865913976 2 97664261 97664271 11 + 0.194 0.243 0.410
ENSG00000228486 E005 3.0174746 0.005608465 0.5658978257 0.692935207 2 97664272 97664472 201 + 0.549 0.642 0.413
ENSG00000228486 E006 0.6642364 0.020012511 0.7855347552 0.862578410 2 97665803 97665823 21 + 0.194 0.243 0.412
ENSG00000228486 E007 1.3211111 0.010653168 0.2777636724 0.417372535 2 97665824 97665920 97 + 0.266 0.459 1.148
ENSG00000228486 E008 0.8041237 0.016178915 0.4574254497 0.597747728 2 97665921 97665940 20 + 0.194 0.327 0.996
ENSG00000228486 E009 1.0287911 0.013475438 0.7407821644 0.830124280 2 97666904 97666956 53 + 0.266 0.328 0.413
ENSG00000228486 E010 1.0621892 0.015041476 0.7397090326 0.829357202 2 97666957 97667054 98 + 0.266 0.328 0.415
ENSG00000228486 E011 1.5176779 0.009950906 0.1611881564 0.276652376 2 97667964 97668073 110 + 0.266 0.512 1.411
ENSG00000228486 E012 5.5054926 0.042789066 0.2877042665 0.428223460 2 97668091 97668627 537 + 0.874 0.713 -0.641
ENSG00000228486 E013 3.9418278 0.228387513 0.7562910326 0.841380880 2 97668648 97669122 475 + 0.694 0.663 -0.129
ENSG00000228486 E014 4.4494073 0.005018749 0.1095644348 0.204935167 2 97669180 97669685 506 + 0.822 0.603 -0.909
ENSG00000228486 E015 1.8435134 0.007960425 0.1905282201 0.314421851 2 97669686 97669689 4 + 0.549 0.327 -1.174
ENSG00000228486 E016 2.2498721 0.006960877 0.2598213219 0.397281392 2 97669690 97669712 23 + 0.582 0.398 -0.909
ENSG00000228486 E017 2.2562148 0.006889070 0.2598938002 0.397366558 2 97669713 97669742 30 + 0.582 0.398 -0.910
ENSG00000228486 E018 1.1426289 0.011251605 0.9843988553 0.994323882 2 97669743 97669745 3 + 0.328 0.328 -0.003
ENSG00000228486 E019 1.4715823 0.009949220 0.9409235645 0.966851016 2 97669746 97669775 30 + 0.382 0.398 0.090
ENSG00000228486 E020 1.1426289 0.011251605 0.9843988553 0.994323882 2 97669776 97669792 17 + 0.328 0.328 -0.003
ENSG00000228486 E021 1.0726991 0.011836452 0.4261286800 0.568981485 2 97669793 97669798 6 + 0.382 0.243 -0.911
ENSG00000228486 E022 0.9254501 0.013493721 0.6210376366 0.738062580 2 97669799 97669799 1 + 0.328 0.243 -0.590
ENSG00000228486 E023 0.9254501 0.013493721 0.6210376366 0.738062580 2 97669800 97669816 17 + 0.328 0.243 -0.590
ENSG00000228486 E024 0.9254501 0.013493721 0.6210376366 0.738062580 2 97669817 97669818 2 + 0.328 0.243 -0.590
ENSG00000228486 E025 1.2941444 0.010221649 0.7435484360 0.832174564 2 97669819 97669834 16 + 0.382 0.328 -0.325
ENSG00000228486 E026 1.5135132 0.009724121 0.9422273410 0.967735183 2 97670183 97670565 383 + 0.382 0.398 0.091
ENSG00000228486 E027 0.1451727 0.042659594 0.6222790207   2 97670566 97670589 24 + 0.108 0.000 -13.545
ENSG00000228486 E028 0.5117906 0.268143921 0.7956024700 0.869481679 2 97670590 97670689 100 + 0.194 0.141 -0.558
ENSG00000228486 E029 0.3666179 0.027859445 0.8419829752 0.901476740 2 97670690 97670705 16 + 0.108 0.139 0.415
ENSG00000228486 E030 0.6590396 0.019766962 0.4553791749 0.595909522 2 97670706 97670972 267 + 0.266 0.139 -1.171
ENSG00000228486 E031 0.2955422 0.028428578 0.8430212968   2 97670973 97671146 174 + 0.108 0.138 0.409
ENSG00000228486 E032 0.1482932 0.041616114 0.3782062749   2 97671147 97671190 44 + 0.000 0.138 13.293
ENSG00000228486 E033 0.2965864 0.185268301 0.1720521945   2 97671191 97671193 3 + 0.000 0.240 14.007
ENSG00000228486 E034 0.4417591 0.083681065 0.4461514525 0.587676982 2 97671194 97671219 26 + 0.108 0.241 1.399
ENSG00000228486 E035 0.9503405 0.029146047 0.2631580661 0.401022154 2 97671220 97671306 87 + 0.194 0.397 1.408
ENSG00000228486 E036 0.5106578 0.157128644 0.4572531679 0.597609162 2 97671307 97671330 24 + 0.108 0.244 1.417
ENSG00000228486 E037 1.4715954 0.453731066 0.8780550615 0.925685152 2 97671331 97671374 44 + 0.383 0.401 0.103
ENSG00000228486 E038 1.4652527 0.015718866 0.9422576098 0.967737884 2 97671375 97671400 26 + 0.382 0.398 0.091
ENSG00000228486 E039 2.1380219 0.008578120 0.8332516044 0.895530865 2 97671401 97671481 81 + 0.474 0.512 0.190
ENSG00000228486 E040 0.9715337 0.062923076 0.6445870601 0.756854736 2 97671482 97671499 18 + 0.328 0.243 -0.589
ENSG00000228486 E041 0.4439371 0.021766993 0.1335662373 0.239095567 2 97671500 97671574 75 + 0.266 0.000 -14.717
ENSG00000228486 E042 2.1831620 0.023462812 0.7386453497 0.828471740 2 97671575 97671788 214 + 0.513 0.460 -0.261
ENSG00000228486 E043 0.3634088 0.320199787 0.1999293263   2 97672279 97672450 172 + 0.000 0.244 13.961
ENSG00000228486 E044 3.1042345 0.005831436 0.0289693076 0.069947470 2 97674203 97674327 125 + 0.742 0.398 -1.588
ENSG00000228486 E045 4.0725591 0.006493397 0.0876283873 0.171532704 2 97674328 97674455 128 + 0.804 0.560 -1.029
ENSG00000228486 E046 4.4266158 0.006427478 0.7933728024 0.867885215 2 97674456 97674501 46 + 0.742 0.710 -0.128
ENSG00000228486 E047 4.9037370 0.003540458 0.6045224045 0.725039817 2 97674502 97674557 56 + 0.804 0.741 -0.252
ENSG00000228486 E048 0.8136755 0.014801000 0.8840163437 0.929838510 2 97674558 97674561 4 + 0.266 0.243 -0.173
ENSG00000228486 E049 3.6482904 0.005959154 0.0901645113 0.175375107 2 97675631 97675721 91 + 0.763 0.512 -1.090
ENSG00000228486 E050 0.0000000       2 97675821 97675844 24 +      
ENSG00000228486 E051 5.2044775 0.096507234 0.5371467668 0.668788446 2 97675845 97675928 84 + 0.840 0.759 -0.321
ENSG00000228486 E052 0.1451727 0.042659594 0.6222790207   2 97677415 97677418 4 + 0.108 0.000 -13.545
ENSG00000228486 E053 1.7692895 0.010622083 0.2804587611 0.420312666 2 97677419 97677755 337 + 0.513 0.328 -1.002
ENSG00000228486 E054 0.1817044 0.039259339 0.3769297208   2 97688895 97688924 30 + 0.000 0.138 13.298
ENSG00000228486 E055 0.5106578 0.157128644 0.4572531679 0.597609162 2 97688925 97688993 69 + 0.108 0.244 1.417
ENSG00000228486 E056 4.3273246 0.005846561 0.3758565585 0.520258782 2 97690256 97690327 72 + 0.669 0.796 0.516
ENSG00000228486 E057 0.0000000       2 97690992 97691055 64 +      
ENSG00000228486 E058 0.0000000       2 97691056 97691150 95 +      
ENSG00000228486 E059 0.9996463 0.013619082 0.7426695933 0.831515182 2 97694447 97694455 9 + 0.266 0.328 0.412
ENSG00000228486 E060 1.1479395 0.012237336 0.4663147397 0.605872242 2 97694456 97694531 76 + 0.266 0.398 0.826
ENSG00000228486 E061 1.2576101 0.013984047 0.1356161393 0.241969417 2 97694532 97694599 68 + 0.194 0.459 1.735
ENSG00000228486 E062 0.0000000       2 97697257 97697321 65 +      
ENSG00000228486 E063 0.3634088 0.320199787 0.1999293263   2 97697919 97698104 186 + 0.000 0.244 13.961
ENSG00000228486 E064 5.5679087 0.042028614 0.1908809501 0.314846473 2 97699026 97699136 111 + 0.719 0.924 0.807
ENSG00000228486 E065 0.3634088 0.320199787 0.1999293263   2 97699137 97699139 3 + 0.000 0.244 13.961
ENSG00000228486 E066 4.0555018 0.008427006 0.2089671625 0.337285424 2 97701154 97701304 151 + 0.613 0.796 0.758
ENSG00000228486 E067 1.4047599 0.014332113 0.9440946714 0.968964346 2 97702061 97702167 107 + 0.382 0.398 0.087
ENSG00000228486 E068 8.2345543 0.002534726 0.0005464699 0.002333846 2 97702669 97703066 398 + 0.742 1.127 1.455