ENSG00000227885

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000453790 ENSG00000227885 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 0.5898315 0.6013049 0.6128528 0.04452782 0.08331879 0.02699917 0.08333427 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.13350833 0.00000000 0.0000000 0.00000000   0.005538356   FALSE
ENST00000648812 ENSG00000227885 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 0.5898315 0.6013049 0.6128528 0.04452782 0.08331879 0.02699917 0.21700805 0.28677649 0.17302626 0.04243728 0.02742611 -0.6973262 0.39329583 0.48553333 0.2878000 -0.19773333 0.348665628 0.005538356   FALSE
ENST00000657329 ENSG00000227885 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 0.5898315 0.6013049 0.6128528 0.04452782 0.08331879 0.02699917 0.05651843 0.04233046 0.07621396 0.02118832 0.01219638 0.7202705 0.09686667 0.06583333 0.1260667 0.06023333 0.806661930 0.005538356 FALSE FALSE
ENST00000661706 ENSG00000227885 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 0.5898315 0.6013049 0.6128528 0.04452782 0.08331879 0.02699917 0.06767508 0.05565385 0.11278431 0.02983098 0.03014336 0.9031746 0.11860417 0.09690000 0.1974000 0.10050000 0.594621220 0.005538356 TRUE FALSE
ENST00000662688 ENSG00000227885 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 0.5898315 0.6013049 0.6128528 0.04452782 0.08331879 0.02699917 0.12523990 0.21654412 0.07834161 0.04874288 0.07834161 -1.3586270 0.19091667 0.35166667 0.1080000 -0.24366667 0.258602443 0.005538356   FALSE
ENST00000666996 ENSG00000227885 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 0.5898315 0.6013049 0.6128528 0.04452782 0.08331879 0.02699917 0.02303695 0.00000000 0.17248672 0.00000000 0.06592436 4.1897196 0.03755000 0.00000000 0.2807000 0.28070000 0.005538356 0.005538356   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000227885 E001 3.2420167 0.058443251 0.2710872183 0.409784528 6 53739266 53740630 1365 - 0.724 0.527 -0.861
ENSG00000227885 E002 0.5138669 0.022126093 0.4954991706 0.632292867 6 53740631 53740748 118 - 0.235 0.112 -1.280
ENSG00000227885 E003 2.5206377 0.006610484 0.0043334915 0.014078385 6 53740749 53741338 590 - 0.753 0.275 -2.397
ENSG00000227885 E004 1.1888288 0.011531097 0.0009586221 0.003816819 6 53744219 53744364 146 - 0.588 0.000 -14.361
ENSG00000227885 E005 2.1066885 0.011226986 0.1896231816 0.313277604 6 53745732 53746381 650 - 0.626 0.393 -1.134
ENSG00000227885 E006 0.2987644 0.029229092 0.1679348616   6 53746382 53746408 27 - 0.235 0.000 -12.361
ENSG00000227885 E007 3.9729102 0.005297883 0.1681328633 0.285765419 6 53746409 53746515 107 - 0.588 0.757 0.717
ENSG00000227885 E008 7.3030667 0.002646969 0.4726979827 0.611749089 6 53746516 53746603 88 - 0.873 0.923 0.193
ENSG00000227885 E009 5.1105458 0.020756832 0.4103232747 0.553921071 6 53746909 53747013 105 - 0.851 0.712 -0.556
ENSG00000227885 E010 0.0000000       6 53747014 53747022 9 -      
ENSG00000227885 E011 0.1482932 0.043104507 0.5493676734   6 53790875 53791188 314 - 0.000 0.112 10.518
ENSG00000227885 E012 8.7925302 0.002151519 0.1826457538 0.304509246 6 53793283 53793349 67 - 0.913 1.019 0.396
ENSG00000227885 E013 3.2579349 0.005905478 0.9730860037 0.987199175 6 53793350 53793540 191 - 0.626 0.597 -0.129
ENSG00000227885 E014 7.9660780 0.002411347 0.0006019301 0.002540366 6 53793541 53794172 632 - 0.694 1.054 1.388
ENSG00000227885 E015 5.5526574 0.003615506 0.4643806454 0.604107150 6 53794173 53794904 732 - 0.873 0.757 -0.453