ENSG00000227398

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000429315 ENSG00000227398 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.848644 4.203897 4.202252 0.2743162 0.1957215 -0.0005630252 0.7553440 0.50613592 0.9910034 0.10780915 0.03710260 0.9556239 0.19975417 0.12033333 0.2377000 0.11736667 4.461899e-02 1.521998e-07 FALSE FALSE
ENST00000689153 ENSG00000227398 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.848644 4.203897 4.202252 0.2743162 0.1957215 -0.0005630252 1.2918051 2.28105707 0.8499559 0.22046974 0.13808071 -1.4136788 0.33468750 0.54120000 0.2004000 -0.34080000 1.521998e-07 1.521998e-07   FALSE
MSTRG.22873.2 ENSG00000227398 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   3.848644 4.203897 4.202252 0.2743162 0.1957215 -0.0005630252 0.2791182 0.11979128 0.4760438 0.07464453 0.14809477 1.9048930 0.07326667 0.02673333 0.1162000 0.08946667 1.969802e-01 1.521998e-07   FALSE
MSTRG.22873.3 ENSG00000227398 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   3.848644 4.203897 4.202252 0.2743162 0.1957215 -0.0005630252 0.4701431 0.47918191 0.5304858 0.04803604 0.06605778 0.1438858 0.12788333 0.11656667 0.1254667 0.00890000 9.423207e-01 1.521998e-07 FALSE FALSE
MSTRG.22873.4 ENSG00000227398 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   3.848644 4.203897 4.202252 0.2743162 0.1957215 -0.0005630252 0.6200700 0.54153542 0.9911093 0.08558129 0.12660359 0.8600740 0.15814583 0.12890000 0.2367333 0.10783333 1.049894e-01 1.521998e-07   FALSE
MSTRG.22873.6 ENSG00000227398 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   3.848644 4.203897 4.202252 0.2743162 0.1957215 -0.0005630252 0.2069281 0.08241427 0.1828919 0.04350211 0.15015739 1.0616052 0.05417083 0.02086667 0.0413000 0.02043333 9.532508e-01 1.521998e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000227398 E001 1.1039323 0.011884783 7.145630e-01 8.107165e-01 3 47164186 47164196 11 + 0.297 0.360 0.393
ENSG00000227398 E002 1.1039323 0.011884783 7.145630e-01 8.107165e-01 3 47164197 47164200 4 + 0.297 0.360 0.395
ENSG00000227398 E003 2.1024327 0.007268493 4.153290e-01 5.587238e-01 3 47164201 47164204 4 + 0.421 0.554 0.658
ENSG00000227398 E004 8.0682771 0.002268669 9.273977e-03 2.696948e-02 3 47164205 47164272 68 + 0.772 1.067 1.119
ENSG00000227398 E005 13.5577933 0.001516763 7.187055e-04 2.965793e-03 3 47164273 47164366 94 + 0.963 1.274 1.119
ENSG00000227398 E006 23.9330516 0.007483999 2.867386e-02 6.935520e-02 3 47164367 47164496 130 + 1.294 1.460 0.577
ENSG00000227398 E007 23.7191227 0.000876717 5.255685e-02 1.137146e-01 3 47164497 47164597 101 + 1.315 1.445 0.450
ENSG00000227398 E008 24.2946337 0.001011270 4.859994e-04 2.106601e-03 3 47169169 47169396 228 + 1.248 1.488 0.833
ENSG00000227398 E009 26.8800919 0.001013080 8.898665e-10 1.331708e-08 3 47169397 47169954 558 + 1.159 1.582 1.470
ENSG00000227398 E010 7.7531100 0.002430113 3.807159e-01 5.250033e-01 3 47174040 47174212 173 + 0.993 0.892 -0.381
ENSG00000227398 E011 3.5231890 0.014752921 4.040334e-01 5.477543e-01 3 47175717 47177494 1778 + 0.721 0.592 -0.551
ENSG00000227398 E012 0.8449086 0.014479848 1.713977e-01 2.900134e-01 3 47179428 47179499 72 + 0.123 0.360 1.981
ENSG00000227398 E013 1.8133218 0.007734998 7.613076e-01 8.452147e-01 3 47231767 47231863 97 + 0.472 0.418 -0.281
ENSG00000227398 E014 9.6375221 0.001912133 1.915413e-01 3.156702e-01 3 47236057 47236159 103 + 1.096 0.958 -0.504
ENSG00000227398 E015 5.9957644 0.046399420 2.993026e-01 4.408146e-01 3 47236160 47236186 27 + 0.915 0.748 -0.651
ENSG00000227398 E016 6.2583599 0.003068829 4.206598e-01 5.638491e-01 3 47238404 47238569 166 + 0.914 0.813 -0.391
ENSG00000227398 E017 2.5162695 0.005978312 1.310430e-01 2.356005e-01 3 47239611 47239614 4 + 0.663 0.418 -1.156
ENSG00000227398 E018 22.6071361 0.001880255 5.155427e-04 2.217510e-03 3 47239615 47240194 580 + 1.493 1.243 -0.870
ENSG00000227398 E019 12.3531169 0.001411980 5.731024e-03 1.790347e-02 3 47242979 47243213 235 + 1.248 0.988 -0.936
ENSG00000227398 E020 126.9551094 0.001203144 1.067216e-06 8.803105e-06 3 47243214 47246601 3388 + 2.175 2.044 -0.438