ENSG00000226686

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000591116 ENSG00000226686 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01535 lncRNA lncRNA 3.10408 6.182642 0.8932273 0.06322332 0.06744225 -2.777394 0.21079090 0.38219560 0.00000000 0.05425714 0.00000000 -5.2935014 0.07239583 0.06190000 0.00000000 -0.06190000 0.02416070 0.0241607   FALSE
ENST00000592100 ENSG00000226686 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01535 lncRNA lncRNA 3.10408 6.182642 0.8932273 0.06322332 0.06744225 -2.777394 0.25633594 0.38331645 0.00000000 0.15115653 0.00000000 -5.2976186 0.04668333 0.06183333 0.00000000 -0.06183333 0.07852398 0.0241607   FALSE
ENST00000659928 ENSG00000226686 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01535 lncRNA lncRNA 3.10408 6.182642 0.8932273 0.06322332 0.06744225 -2.777394 0.13447882 0.18750176 0.02578576 0.04642351 0.01475768 -2.4644080 0.06028750 0.03026667 0.03176667 0.00150000 1.00000000 0.0241607 FALSE FALSE
ENST00000666743 ENSG00000226686 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01535 lncRNA lncRNA 3.10408 6.182642 0.8932273 0.06322332 0.06744225 -2.777394 0.10836892 0.00000000 0.04708635 0.00000000 0.04708635 2.5131459 0.04064167 0.00000000 0.06153333 0.06153333 0.43401600 0.0241607 FALSE TRUE
ENST00000688387 ENSG00000226686 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01535 lncRNA lncRNA 3.10408 6.182642 0.8932273 0.06322332 0.06744225 -2.777394 2.02308077 4.61491651 0.60005766 0.17640649 0.02070458 -2.9224098 0.61452917 0.74703333 0.67680000 -0.07023333 0.65241582 0.0241607 TRUE FALSE
ENST00000692449 ENSG00000226686 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01535 lncRNA lncRNA 3.10408 6.182642 0.8932273 0.06322332 0.06744225 -2.777394 0.07244649 0.07603418 0.15041880 0.07603418 0.08264080 0.8988614 0.04736250 0.01253333 0.15580000 0.14326667 0.24127572 0.0241607   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000226686 E001 0.0000000       19 37251867 37251871 5 +      
ENSG00000226686 E002 0.0000000       19 37251872 37251878 7 +      
ENSG00000226686 E003 2.1358282 0.0070988963 0.52644092 0.65967730 19 37251879 37251902 24 + 0.253 0.393 0.897
ENSG00000226686 E004 2.5055666 0.0070190094 0.40265792 0.54642332 19 37251903 37251911 9 + 0.253 0.438 1.138
ENSG00000226686 E005 4.0073499 0.0042698533 0.85069437 0.90739998 19 37251912 37251921 10 + 0.528 0.565 0.174
ENSG00000226686 E006 7.4030509 0.0606294987 0.44885188 0.59009122 19 37251922 37251925 4 + 0.619 0.773 0.641
ENSG00000226686 E007 25.7983695 0.0117510477 0.37547835 0.51991526 19 37251926 37252044 119 + 1.160 1.256 0.342
ENSG00000226686 E008 25.5945476 0.0008535397 0.80189753 0.87377968 19 37252045 37252113 69 + 1.226 1.252 0.092
ENSG00000226686 E009 28.0629676 0.0018366898 0.78486478 0.86205758 19 37252114 37252182 69 + 1.265 1.292 0.096
ENSG00000226686 E010 13.4056527 0.0054739791 0.31509533 0.45785229 19 37255899 37255915 17 + 0.865 1.005 0.526
ENSG00000226686 E011 21.8138746 0.0084761421 0.06503220 0.13508942 19 37255916 37255982 67 + 0.987 1.208 0.798
ENSG00000226686 E012 0.0000000       19 37256188 37256229 42 +      
ENSG00000226686 E013 0.0000000       19 37256230 37256398 169 +      
ENSG00000226686 E014 2.2111583 0.0087769041 0.33799875 0.48188115 19 37256399 37256519 121 + 0.528 0.344 -0.975
ENSG00000226686 E015 4.5318390 0.0040594697 0.49892415 0.63531540 19 37256727 37256814 88 + 0.695 0.581 -0.492
ENSG00000226686 E016 0.9964241 0.0127524553 0.24455132 0.37952612 19 37257012 37257230 219 + 0.412 0.186 -1.564
ENSG00000226686 E017 4.2481009 0.1489768876 0.12653550 0.22932252 19 37257231 37257394 164 + 0.816 0.512 -1.300
ENSG00000226686 E018 1.2576101 0.0295429617 0.34321772 0.48727560 19 37258948 37259069 122 + 0.412 0.223 -1.237
ENSG00000226686 E019 3.0223781 0.0279445228 0.04141096 0.09364474 19 37262355 37262434 80 + 0.000 0.530 11.084
ENSG00000226686 E020 25.2970335 0.0040680199 0.85158820 0.90797509 19 37262542 37262655 114 + 1.265 1.251 -0.049
ENSG00000226686 E021 2.6506401 0.0075214259 0.26420518 0.40216360 19 37262656 37263083 428 + 0.620 0.416 -0.980
ENSG00000226686 E022 6.1451683 0.0029423830 0.69727262 0.79743682 19 37263084 37263678 595 + 0.759 0.700 -0.242
ENSG00000226686 E023 2.8753352 0.0061654984 0.01077891 0.03063631 19 37263679 37264695 1017 + 0.815 0.393 -1.913
ENSG00000226686 E024 3.0642996 0.0162658879 0.05909791 0.12508012 19 37264696 37264755 60 + 0.759 0.437 -1.454
ENSG00000226686 E025 5.0204126 0.0619749221 0.22484165 0.35624562 19 37264756 37265285 530 + 0.815 0.616 -0.821
ENSG00000226686 E026 15.2867660 0.0168573167 0.93269897 0.96161459 19 37265286 37265547 262 + 1.052 1.050 -0.010