ENSG00000226530

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000455931 ENSG00000226530 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.976522 2.05153 1.404754 0.269318 0.2911242 -0.5431643 0.4164292 0.44484120 0.2598764 0.193764046 0.16038865 -0.7530643 0.19273750 0.20180000 0.1675333 -0.03426667 8.864566e-01 2.594224e-09   FALSE
ENST00000661364 ENSG00000226530 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.976522 2.05153 1.404754 0.269318 0.2911242 -0.5431643 0.1187060 0.10157895 0.3637251 0.005823012 0.04285950 1.7439126 0.07636667 0.05200000 0.2905667 0.23856667 9.164188e-03 2.594224e-09 FALSE FALSE
ENST00000690416 ENSG00000226530 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.976522 2.05153 1.404754 0.269318 0.2911242 -0.5431643 0.1001394 0.03742453 0.0000000 0.021044882 0.00000000 -2.2456334 0.05102083 0.01826667 0.0000000 -0.01826667 4.206544e-01 2.594224e-09 FALSE FALSE
ENST00000692522 ENSG00000226530 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.976522 2.05153 1.404754 0.269318 0.2911242 -0.5431643 0.1245193 0.00000000 0.3827742 0.000000000 0.02256239 5.2956281 0.07967500 0.00000000 0.2881333 0.28813333 2.594224e-09 2.594224e-09 FALSE FALSE
MSTRG.34266.2 ENSG00000226530 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   1.976522 2.05153 1.404754 0.269318 0.2911242 -0.5431643 1.1891461 1.46318738 0.3983782 0.134510828 0.20722972 -1.8509632 0.58636250 0.72583333 0.2537333 -0.47210000 1.436507e-01 2.594224e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000226530 E001 0.0000000       X 51395915 51395924 10 +      
ENSG00000226530 E002 0.1817044 0.039957484 4.130763e-01   X 51395925 51395928 4 + 0.000 0.128 10.698
ENSG00000226530 E003 23.5411724 0.020631404 2.069480e-02 5.294486e-02 X 51395929 51396510 582 + 1.298 1.459 0.559
ENSG00000226530 E004 5.6378502 0.003220097 2.688432e-02 6.575289e-02 X 51396511 51396530 20 + 0.673 0.932 1.026
ENSG00000226530 E005 14.2112009 0.001945136 2.211095e-04 1.054250e-03 X 51396531 51396681 151 + 1.024 1.312 1.028
ENSG00000226530 E006 6.6986050 0.002761813 1.777439e-05 1.115075e-04 X 51396682 51398115 1434 + 1.094 0.532 -2.250
ENSG00000226530 E007 49.2930447 0.024778638 1.832698e-05 1.146846e-04 X 51398116 51405927 7812 + 1.822 1.553 -0.911
ENSG00000226530 E008 2.2957772 0.010410414 5.835190e-02 1.237999e-01 X 51465407 51465661 255 + 0.349 0.646 1.471
ENSG00000226530 E009 3.6009025 0.005117639 2.102123e-08 2.440501e-07 X 51638178 51638287 110 + 0.000 0.914 15.087
ENSG00000226530 E010 0.5514428 0.020368898 6.092658e-02 1.281957e-01 X 51639780 51639829 50 + 0.000 0.307 12.283