ENSG00000226314

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000440790 ENSG00000226314 HEK293_OSMI2_2hA HEK293_TMG_2hB ZKSCAN8P1 protein_coding protein_coding 2.16502 1.159156 2.500448 0.1510202 0.2995902 1.102477 1.05730469 0.45736730 1.0404179 0.11162798 0.13089604 1.1683347 0.4674417 0.39996667 0.43073333 0.03076667 0.93556432 0.04013732 TRUE TRUE
ENST00000562227 ENSG00000226314 HEK293_OSMI2_2hA HEK293_TMG_2hB ZKSCAN8P1 protein_coding protein_coding 2.16502 1.159156 2.500448 0.1510202 0.2995902 1.102477 0.09782305 0.00000000 0.3797697 0.00000000 0.21177770 5.2845499 0.0362125 0.00000000 0.15440000 0.15440000 0.04013732 0.04013732 TRUE TRUE
ENST00000570042 ENSG00000226314 HEK293_OSMI2_2hA HEK293_TMG_2hB ZKSCAN8P1 protein_coding retained_intron 2.16502 1.159156 2.500448 0.1510202 0.2995902 1.102477 0.12282697 0.06302803 0.1803456 0.03541349 0.12528879 1.3820987 0.0742625 0.05843333 0.06273333 0.00430000 1.00000000 0.04013732   FALSE
ENST00000570126 ENSG00000226314 HEK293_OSMI2_2hA HEK293_TMG_2hB ZKSCAN8P1 protein_coding retained_intron 2.16502 1.159156 2.500448 0.1510202 0.2995902 1.102477 0.29115470 0.01541463 0.2302773 0.01541463 0.07206943 3.2409695 0.1159667 0.01063333 0.10153333 0.09090000 0.23250046 0.04013732   FALSE
MSTRG.27883.2 ENSG00000226314 HEK293_OSMI2_2hA HEK293_TMG_2hB ZKSCAN8P1 protein_coding   2.16502 1.159156 2.500448 0.1510202 0.2995902 1.102477 0.47931557 0.59408453 0.5112444 0.16423440 0.26915033 -0.2127903 0.2334208 0.51083333 0.18236667 -0.32846667 0.38328118 0.04013732   FALSE
MSTRG.27883.3 ENSG00000226314 HEK293_OSMI2_2hA HEK293_TMG_2hB ZKSCAN8P1 protein_coding   2.16502 1.159156 2.500448 0.1510202 0.2995902 1.102477 0.11659545 0.02926170 0.1583935 0.02926170 0.07955924 2.1006419 0.0727000 0.02016667 0.06830000 0.04813333 0.77471086 0.04013732 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000226314 E001 0.3686942 0.0316121416 0.57034169 0.69684193 6 28161769 28161775 7 + 0.088 0.168 1.069
ENSG00000226314 E002 0.9201370 0.0194256013 0.02813586 0.06828320 6 28161776 28161777 2 + 0.088 0.461 3.069
ENSG00000226314 E003 0.9201370 0.0194256013 0.02813586 0.06828320 6 28161778 28161780 3 + 0.088 0.461 3.069
ENSG00000226314 E004 1.8831379 0.1221458600 0.15803591 0.27251603 6 28161781 28161791 11 + 0.327 0.586 1.346
ENSG00000226314 E005 4.3325094 0.0092958345 0.08523282 0.16778476 6 28161792 28161821 30 + 0.618 0.852 0.957
ENSG00000226314 E006 1.3004871 0.0124264222 0.74083262 0.83015022 6 28162418 28162579 162 + 0.327 0.383 0.330
ENSG00000226314 E007 5.5536155 0.0033859108 0.08743685 0.17125332 6 28162580 28162608 29 + 0.722 0.931 0.817
ENSG00000226314 E008 9.0328990 0.0026682120 0.17151109 0.29016648 6 28162609 28162766 158 + 0.937 1.073 0.501
ENSG00000226314 E009 0.8825757 0.0155701996 0.40179642 0.54548868 6 28162767 28162942 176 + 0.327 0.167 -1.256
ENSG00000226314 E010 2.9336924 0.2188540221 0.19881127 0.32470816 6 28162943 28163100 158 + 0.681 0.375 -1.473
ENSG00000226314 E011 1.9176990 0.0078671151 0.03465279 0.08098674 6 28163101 28163511 411 + 0.568 0.168 -2.519
ENSG00000226314 E012 7.6467543 0.0025494319 0.33041858 0.47400997 6 28164749 28164901 153 + 0.969 0.852 -0.443
ENSG00000226314 E013 7.4398825 0.0480808259 0.03610911 0.08379797 6 28166501 28166654 154 + 1.009 0.677 -1.293
ENSG00000226314 E014 29.5834908 0.0007937272 0.16739054 0.28480776 6 28166655 28167554 900 + 1.503 1.422 -0.277
ENSG00000226314 E015 11.4269392 0.0137095787 0.37813193 0.52242500 6 28169402 28169624 223 + 1.055 1.135 0.290