ENSG00000226287

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000422715 ENSG00000226287 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM191A transcribed_unprocessed_pseudogene retained_intron 8.503048 17.67815 2.779846 0.8987489 0.3704239 -2.664526 0.4625522 1.582077 0.0000000 0.8061842 0.0000000 -7.314767 0.04601667 0.08536667 0.00000000 -0.08536667 0.40501875 0.01984514 FALSE FALSE
ENST00000428752 ENSG00000226287 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM191A transcribed_unprocessed_pseudogene retained_intron 8.503048 17.67815 2.779846 0.8987489 0.3704239 -2.664526 0.1791984 0.000000 0.2757233 0.0000000 0.1685557 4.836547 0.04282083 0.00000000 0.08610000 0.08610000 0.01984514 0.01984514 TRUE FALSE
ENST00000452055 ENSG00000226287 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM191A transcribed_unprocessed_pseudogene retained_intron 8.503048 17.67815 2.779846 0.8987489 0.3704239 -2.664526 2.3899565 5.840928 0.9575039 1.1308331 0.4844729 -2.596326 0.28260417 0.32576667 0.37116667 0.04540000 0.98606324 0.01984514   FALSE
ENST00000689656 ENSG00000226287 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM191A transcribed_unprocessed_pseudogene processed_transcript 8.503048 17.67815 2.779846 0.8987489 0.3704239 -2.664526 1.7406849 2.601781 0.3670077 0.1073104 0.1891285 -2.792368 0.18783750 0.14850000 0.11790000 -0.03060000 0.80273917 0.01984514   FALSE
MSTRG.21677.6 ENSG00000226287 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM191A transcribed_unprocessed_pseudogene   8.503048 17.67815 2.779846 0.8987489 0.3704239 -2.664526 0.8222980 1.647292 0.2262081 0.8236469 0.2262081 -2.810697 0.09075000 0.09556667 0.08143333 -0.01413333 0.73520533 0.01984514   FALSE
MSTRG.21677.7 ENSG00000226287 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM191A transcribed_unprocessed_pseudogene   8.503048 17.67815 2.779846 0.8987489 0.3704239 -2.664526 1.4494209 3.450435 0.5439244 0.8371245 0.3064364 -2.643192 0.15907500 0.20113333 0.18290000 -0.01823333 0.86972991 0.01984514   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000226287 E001 0.0000000       22 20701114 20702006 893 +      
ENSG00000226287 E002 0.3289534 0.0287759409 1.364081e-01   22 20702007 20702191 185 + 0.284 0.047 -3.003
ENSG00000226287 E003 1.5394489 0.1194010626 2.196038e-02 0.0555911145 22 20702192 20702306 115 + 0.671 0.199 -2.663
ENSG00000226287 E004 1.9479090 0.0662890176 1.702881e-01 0.2885509074 22 20702312 20702460 149 + 0.576 0.285 -1.577
ENSG00000226287 E005 0.0000000       22 20702531 20702585 55 +      
ENSG00000226287 E006 2.4209779 0.0134459647 3.094891e-03 0.0105450948 22 20702586 20702626 41 + 0.815 0.284 -2.584
ENSG00000226287 E007 3.2012527 0.0051047609 5.573318e-02 0.1192388785 22 20702627 20702676 50 + 0.749 0.397 -1.623
ENSG00000226287 E008 7.2545975 0.0023558308 5.060224e-01 0.6417229797 22 20702677 20702709 33 + 0.815 0.701 -0.458
ENSG00000226287 E009 5.9992239 0.0238024812 3.547565e-01 0.4990779277 22 20702710 20702829 120 + 0.454 0.652 0.920
ENSG00000226287 E010 9.0217910 0.0091406338 4.859816e-01 0.6237906142 22 20702830 20702840 11 + 0.671 0.792 0.496
ENSG00000226287 E011 9.9032313 0.0031192999 3.478856e-01 0.4921029945 22 20702841 20702843 3 + 0.671 0.830 0.643
ENSG00000226287 E012 15.2629370 0.0012879287 2.053018e-01 0.3328012741 22 20702844 20702893 50 + 0.815 0.999 0.699
ENSG00000226287 E013 4.0730394 0.0042627546 6.922451e-01 0.7935313649 22 20702921 20702959 39 + 0.454 0.533 0.390
ENSG00000226287 E014 6.0992101 0.0088980814 9.681261e-01 0.9840835787 22 20702960 20702972 13 + 0.671 0.659 -0.049
ENSG00000226287 E015 6.8292368 0.0162039669 7.600281e-01 0.8442355789 22 20702973 20702974 2 + 0.749 0.691 -0.236
ENSG00000226287 E016 12.3231422 0.0095931099 6.591955e-01 0.7680640199 22 20702975 20703005 31 + 0.968 0.899 -0.261
ENSG00000226287 E017 33.6719112 0.0006579832 4.543322e-01 0.5949615376 22 20703006 20703044 39 + 1.245 1.313 0.237
ENSG00000226287 E018 28.4843460 0.0007704853 8.273449e-01 0.8914432053 22 20703045 20703051 7 + 1.222 1.239 0.060
ENSG00000226287 E019 33.0023668 0.0006895030 9.551853e-01 0.9758776669 22 20703052 20703094 43 + 1.309 1.298 -0.037
ENSG00000226287 E020 21.3986193 0.0013298282 4.410671e-01 0.5827098539 22 20703095 20703122 28 + 1.047 1.135 0.319
ENSG00000226287 E021 41.7138012 0.0100409744 5.421627e-03 0.0170738390 22 20703468 20703524 57 + 1.113 1.424 1.093
ENSG00000226287 E022 49.3637897 0.0018697882 9.321267e-01 0.9612461553 22 20703633 20703692 60 + 1.471 1.473 0.008
ENSG00000226287 E023 59.1803463 0.0037935476 7.024219e-01 0.8012535788 22 20703693 20703751 59 + 1.578 1.547 -0.107
ENSG00000226287 E024 2.3011645 0.0285880397 5.637294e-04 0.0023982289 22 20703752 20703818 67 + 0.872 0.256 -3.005
ENSG00000226287 E025 2.9988121 0.0053928284 5.235997e-05 0.0002935701 22 20703819 20703883 65 + 0.968 0.309 -3.003
ENSG00000226287 E026 3.5200659 0.0066002435 3.813896e-05 0.0002209508 22 20703884 20703967 84 + 1.009 0.355 -2.865
ENSG00000226287 E027 79.8938851 0.0004495376 5.554664e-01 0.6843298378 22 20703968 20704040 73 + 1.646 1.677 0.104
ENSG00000226287 E028 9.6096914 0.0018842739 1.597492e-01 0.2747876191 22 20704041 20704056 16 + 0.576 0.829 1.057
ENSG00000226287 E029 15.4272240 0.0024071009 9.537902e-02 0.1834629879 22 20704057 20704187 131 + 0.749 1.004 0.982
ENSG00000226287 E030 51.8145647 0.0005667172 6.694367e-01 0.7762536525 22 20704188 20704228 41 + 1.522 1.485 -0.126
ENSG00000226287 E031 0.1515154 0.0415126903 4.067314e-02   22 20704229 20704254 26 + 0.284 0.000 -12.509
ENSG00000226287 E032 65.0790098 0.0004544859 8.372288e-01 0.8982307426 22 20704311 20704606 296 + 1.578 1.587 0.029