ENSG00000226259

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000513202 ENSG00000226259 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 5.552295 2.441236 9.912482 0.8882515 0.5994769 2.017192 0.02731628 0.21853027 0.0000000 0.21853027 0.0000000 -4.5143134 0.007545833 0.06036667 0.000000000 -0.06036667 4.408862e-01 4.271459e-08 FALSE TRUE
MSTRG.26337.1 ENSG00000226259 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   5.552295 2.441236 9.912482 0.8882515 0.5994769 2.017192 0.98090330 0.42820714 2.3620568 0.21996007 0.5330139 2.4364537 0.197279167 0.34490000 0.245600000 -0.09930000 1.000000e+00 4.271459e-08 TRUE TRUE
MSTRG.26337.11 ENSG00000226259 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   5.552295 2.441236 9.912482 0.8882515 0.5994769 2.017192 0.19544154 0.16664777 0.0998428 0.16664777 0.0998428 -0.6854353 0.050191667 0.04603333 0.009033333 -0.03700000 7.686797e-01 4.271459e-08 TRUE TRUE
MSTRG.26337.12 ENSG00000226259 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   5.552295 2.441236 9.912482 0.8882515 0.5994769 2.017192 1.41787144 0.00000000 3.3700613 0.00000000 0.7272610 8.4009056 0.177483333 0.00000000 0.341200000 0.34120000 4.271459e-08 4.271459e-08 TRUE TRUE
MSTRG.26337.7 ENSG00000226259 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   5.552295 2.441236 9.912482 0.8882515 0.5994769 2.017192 0.30723404 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000 0.081608333 0.00000000 0.000000000 0.00000000   4.271459e-08 TRUE TRUE
MSTRG.26337.8 ENSG00000226259 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   5.552295 2.441236 9.912482 0.8882515 0.5994769 2.017192 0.98303193 0.03273625 2.1561736 0.03273625 0.3510863 5.6635449 0.140366667 0.04670000 0.222900000 0.17620000 9.537097e-02 4.271459e-08 FALSE TRUE
MSTRG.26337.9 ENSG00000226259 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   5.552295 2.441236 9.912482 0.8882515 0.5994769 2.017192 0.66876094 1.28148827 1.0420238 0.64161105 1.0420238 -0.2958672 0.121900000 0.38930000 0.094266667 -0.29503333 3.110956e-01 4.271459e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000226259 E001 0.3666179 0.0293022904 0.29297750 0.43401605 5 70401437 70401439 3 + 0.064 0.223 2.078
ENSG00000226259 E002 1.9940853 0.0509422398 0.73137633 0.82304438 5 70401440 70401479 40 + 0.438 0.369 -0.383
ENSG00000226259 E003 2.7680200 0.0139995471 0.76237984 0.84596865 5 70401480 70401489 10 + 0.508 0.565 0.267
ENSG00000226259 E004 2.9131927 0.0308099670 0.85019477 0.90708670 5 70401490 70401497 8 + 0.529 0.565 0.167
ENSG00000226259 E005 10.3651133 0.0745382312 0.08127258 0.16154153 5 70401498 70401668 171 + 0.918 1.171 0.928
ENSG00000226259 E006 0.5827671 0.1236529351 0.49606172 0.63280187 5 70406842 70406915 74 + 0.213 0.000 -11.148
ENSG00000226259 E007 0.1515154 0.0464516939 1.00000000   5 70415184 70415326 143 + 0.064 0.000 -9.320
ENSG00000226259 E008 0.0000000       5 70415327 70415331 5 +      
ENSG00000226259 E009 0.0000000       5 70415332 70415340 9 +      
ENSG00000226259 E010 0.0000000       5 70415341 70415349 9 +      
ENSG00000226259 E011 0.0000000       5 70415350 70415351 2 +      
ENSG00000226259 E012 0.0000000       5 70415352 70415369 18 +      
ENSG00000226259 E013 0.2944980 0.3411300252 1.00000000   5 70415370 70415389 20 + 0.120 0.000 -10.244
ENSG00000226259 E014 0.0000000       5 70415390 70415395 6 +      
ENSG00000226259 E015 0.1472490 0.0441161417 1.00000000   5 70415396 70415442 47 + 0.064 0.000 -9.319
ENSG00000226259 E016 0.7384352 0.0163738661 0.32435200 0.46770471 5 70415443 70415550 108 + 0.254 0.000 -11.402
ENSG00000226259 E017 0.2987644 0.0278109101 1.00000000   5 70417822 70417919 98 + 0.120 0.000 -10.240
ENSG00000226259 E018 0.0000000       5 70420248 70420248 1 +      
ENSG00000226259 E019 7.6892630 0.0121508959 0.15060689 0.26250343 5 70420249 70420337 89 + 0.826 1.014 0.710
ENSG00000226259 E020 12.1842710 0.0014350246 0.18398481 0.30621355 5 70421280 70421357 78 + 1.077 0.922 -0.574
ENSG00000226259 E021 0.5483223 0.0244973770 0.07305962 0.14842817 5 70421735 70421736 2 + 0.064 0.369 3.078
ENSG00000226259 E022 10.8285141 0.0016464148 0.11868117 0.21806271 5 70421737 70421771 35 + 1.041 0.846 -0.733
ENSG00000226259 E023 12.2208001 0.0014761985 0.94736435 0.97092576 5 70422113 70422199 87 + 1.047 1.042 -0.018
ENSG00000226259 E024 7.4388343 0.0053959104 0.48304913 0.62113342 5 70422873 70422923 51 + 0.826 0.922 0.367
ENSG00000226259 E025 9.6460004 0.0020920388 0.47621122 0.61486572 5 70423299 70423353 55 + 0.973 0.885 -0.331
ENSG00000226259 E026 1.3316951 0.1667094702 0.28112373 0.42100224 5 70423657 70425159 1503 + 0.254 0.481 1.355
ENSG00000226259 E027 19.8845630 0.0009614366 0.02477618 0.06141591 5 70427585 70427690 106 + 1.284 1.068 -0.771
ENSG00000226259 E028 0.0000000       5 70427691 70427991 301 +      
ENSG00000226259 E029 23.7955034 0.0012170353 0.16972265 0.28784251 5 70433870 70433960 91 + 1.344 1.231 -0.396
ENSG00000226259 E030 21.8907217 0.0023135312 0.47731918 0.61589290 5 70434179 70434266 88 + 1.273 1.336 0.220
ENSG00000226259 E031 21.5593964 0.0010112702 0.16263752 0.27859109 5 70434915 70435022 108 + 1.247 1.363 0.405
ENSG00000226259 E032 10.0178257 0.0039381587 0.41076318 0.55435692 5 70437531 70437594 64 + 0.943 1.042 0.367
ENSG00000226259 E033 9.2847010 0.0020108278 0.14099162 0.24938555 5 70440756 70440859 104 + 0.893 1.068 0.649
ENSG00000226259 E034 5.1882056 0.0259685002 0.06238779 0.13066798 5 70441416 70441518 103 + 0.637 0.923 1.146
ENSG00000226259 E035 1.9855525 0.0091031089 0.71558149 0.81146381 5 70445483 70445522 40 + 0.438 0.368 -0.384
ENSG00000226259 E036 0.0000000       5 70447234 70447485 252 +      
ENSG00000226259 E037 17.4529740 0.0136354787 0.03038980 0.07272754 5 70447486 70448088 603 + 1.239 0.985 -0.913
ENSG00000226259 E038 0.0000000       5 70455186 70455328 143 +      
ENSG00000226259 E039 0.0000000       5 70458259 70458357 99 +