ENSG00000226210

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
MSTRG.6604.14 ENSG00000226210 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH8P unprocessed_pseudogene   15.39317 18.81966 9.36772 0.3461207 0.5703851 -1.005698 1.1550731 0.9891742 1.01547141 0.50178218 0.31551541 0.03747917 0.08372083 0.05350000 0.10783333 0.05433333 0.67638463 0.01502617 TRUE TRUE
MSTRG.6604.2 ENSG00000226210 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH8P unprocessed_pseudogene   15.39317 18.81966 9.36772 0.3461207 0.5703851 -1.005698 1.0183794 1.6825806 0.05926466 0.34658341 0.05926466 -4.61096122 0.06775000 0.08886667 0.00690000 -0.08196667 0.01502617 0.01502617 FALSE TRUE
MSTRG.6604.28 ENSG00000226210 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH8P unprocessed_pseudogene   15.39317 18.81966 9.36772 0.3461207 0.5703851 -1.005698 0.9189266 0.6912893 0.51027173 0.25617367 0.27415597 -0.43074450 0.06130417 0.03646667 0.05276667 0.01630000 1.00000000 0.01502617   FALSE
MSTRG.6604.3 ENSG00000226210 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH8P unprocessed_pseudogene   15.39317 18.81966 9.36772 0.3461207 0.5703851 -1.005698 2.9309067 3.8521460 1.75595142 0.63306359 0.17338951 -1.12895705 0.19383333 0.20450000 0.18710000 -0.01740000 0.92212326 0.01502617 FALSE TRUE
MSTRG.6604.30 ENSG00000226210 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH8P unprocessed_pseudogene   15.39317 18.81966 9.36772 0.3461207 0.5703851 -1.005698 2.3338561 1.9661493 1.67199890 0.08854274 0.26042274 -0.23251517 0.15620000 0.10456667 0.17796667 0.07340000 0.07044544 0.01502617 FALSE TRUE
MSTRG.6604.5 ENSG00000226210 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH8P unprocessed_pseudogene   15.39317 18.81966 9.36772 0.3461207 0.5703851 -1.005698 0.8850175 1.3185926 0.42117414 0.55765226 0.29527652 -1.62355618 0.05085417 0.06993333 0.04706667 -0.02286667 0.76888462 0.01502617   TRUE
MSTRG.6604.6 ENSG00000226210 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH8P unprocessed_pseudogene   15.39317 18.81966 9.36772 0.3461207 0.5703851 -1.005698 1.4711593 1.8229629 0.79203749 0.37006022 0.11584010 -1.19243602 0.09488333 0.09676667 0.08460000 -0.01216667 0.89638298 0.01502617 FALSE TRUE
MSTRG.6604.8 ENSG00000226210 HEK293_OSMI2_2hA HEK293_TMG_2hB WASH8P unprocessed_pseudogene   15.39317 18.81966 9.36772 0.3461207 0.5703851 -1.005698 1.8001277 1.8457491 1.56217404 0.55044764 0.16288130 -0.23924070 0.11216667 0.09916667 0.16603333 0.06686667 0.37488513 0.01502617 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000226210 E001 0.1482932 0.0414734283 1.000000e+00   12 14520 14521 2 - 0.001 0.079 7.370
ENSG00000226210 E002 0.2998086 0.0293946431 4.739249e-01   12 14522 14526 5 - 0.184 0.079 -1.404
ENSG00000226210 E003 0.5212538 0.0200131743 8.088904e-01 8.786451e-01 12 14527 14546 20 - 0.184 0.146 -0.401
ENSG00000226210 E004 0.6695470 0.0180097225 9.407111e-01 9.667361e-01 12 14547 14547 1 - 0.184 0.204 0.183
ENSG00000226210 E005 2.6906836 0.1969421521 4.401565e-01 5.818436e-01 12 14548 14548 1 - 0.620 0.460 -0.752
ENSG00000226210 E006 3.2076710 0.1058061016 3.722368e-01 5.166843e-01 12 14549 14550 2 - 0.672 0.514 -0.708
ENSG00000226210 E007 3.7193730 0.0178594160 5.645863e-01 6.918450e-01 12 14551 14556 6 - 0.672 0.582 -0.393
ENSG00000226210 E008 6.1141230 0.0027233080 5.530584e-01 6.822729e-01 12 14557 14574 18 - 0.719 0.807 0.355
ENSG00000226210 E009 6.6645216 0.0024921501 6.153814e-01 7.336687e-01 12 14575 14581 7 - 0.760 0.833 0.288
ENSG00000226210 E010 9.8405802 0.0019025770 2.839196e-01 4.241164e-01 12 14582 14584 3 - 0.866 1.000 0.506
ENSG00000226210 E011 13.8146071 0.0013113429 2.410451e-01 3.754010e-01 12 14585 14607 23 - 1.000 1.128 0.467
ENSG00000226210 E012 18.2064597 0.0010794414 3.022505e-01 4.441032e-01 12 14608 14640 33 - 1.136 1.236 0.354
ENSG00000226210 E013 37.9618091 0.0049931168 6.656278e-01 7.732806e-01 12 14641 14697 57 - 1.493 1.528 0.118
ENSG00000226210 E014 58.7522635 0.0004560124 1.347740e-01 2.407753e-01 12 14698 14747 50 - 1.642 1.725 0.282
ENSG00000226210 E015 91.6988160 0.0021821981 1.101011e-01 2.056821e-01 12 14748 14843 96 - 1.840 1.919 0.264
ENSG00000226210 E016 105.5804201 0.0011151519 7.587908e-01 8.433101e-01 12 14844 14944 101 - 1.948 1.965 0.055
ENSG00000226210 E017 60.6255633 0.0185555432 7.629252e-01 8.464175e-01 12 15085 15153 69 - 1.739 1.720 -0.065
ENSG00000226210 E018 55.6117866 0.0172523422 1.453416e-01 2.553229e-01 12 15913 16060 148 - 1.586 1.717 0.444
ENSG00000226210 E019 29.5650782 0.0247849253 3.958142e-01 5.396022e-01 12 16061 16065 5 - 1.346 1.447 0.352
ENSG00000226210 E020 14.3683794 0.0437793266 2.128551e-01 3.418974e-01 12 16066 16245 180 - 1.241 1.090 -0.539
ENSG00000226210 E021 12.9980498 0.0294922924 2.689102e-01 4.073746e-01 12 16246 16425 180 - 1.184 1.058 -0.455
ENSG00000226210 E022 76.5420624 0.0071484156 8.791359e-01 9.263772e-01 12 16722 16880 159 - 1.813 1.828 0.052
ENSG00000226210 E023 55.4634747 0.0004772419 7.275013e-01 8.201752e-01 12 16969 17170 202 - 1.696 1.682 -0.048
ENSG00000226210 E024 35.2352694 0.0006047643 3.935576e-01 5.374540e-01 12 17348 17483 136 - 1.529 1.478 -0.175
ENSG00000226210 E025 12.8042336 0.0029962542 4.815002e-01 6.197348e-01 12 17484 17642 159 - 1.119 1.050 -0.250
ENSG00000226210 E026 11.2859771 0.0021056236 2.892896e-01 4.299750e-01 12 17643 17722 80 - 1.101 0.992 -0.400
ENSG00000226210 E027 67.1253237 0.0058022097 6.519633e-01 7.627288e-01 12 17723 17859 137 - 1.776 1.753 -0.078
ENSG00000226210 E028 98.9220141 0.0062187780 8.302163e-01 8.934649e-01 12 18037 18183 147 - 1.913 1.929 0.054
ENSG00000226210 E029 46.3854750 0.0120200859 9.159893e-01 9.508780e-01 12 18373 18471 99 - 1.586 1.605 0.064
ENSG00000226210 E030 8.3409881 0.0020716332 7.219800e-01 8.161938e-01 12 18472 18474 3 - 0.866 0.914 0.185
ENSG00000226210 E031 5.6336553 0.0029413115 7.688127e-01 8.506011e-01 12 18475 18484 10 - 0.719 0.764 0.185
ENSG00000226210 E032 6.8340251 0.0025419835 5.322200e-02 1.148874e-01 12 18485 18695 211 - 1.000 0.764 -0.903
ENSG00000226210 E033 27.3355853 0.0014067805 7.005979e-02 1.434676e-01 12 19018 19325 308 - 1.471 1.343 -0.440
ENSG00000226210 E034 27.7202283 0.0171961278 2.849959e-01 4.252949e-01 12 21132 21266 135 - 1.463 1.366 -0.334
ENSG00000226210 E035 19.3769364 0.0010116263 3.467680e-03 1.163222e-02 12 21817 21920 104 - 1.404 1.171 -0.815
ENSG00000226210 E036 23.2488707 0.0178551085 8.314767e-04 3.371447e-03 12 21921 22032 112 - 1.522 1.212 -1.076
ENSG00000226210 E037 6.6815709 0.0053050056 1.285131e-05 8.324419e-05 12 25296 25681 386 - 1.153 0.624 -2.043
ENSG00000226210 E038 20.6080644 0.0439306854 3.951843e-01 5.390111e-01 12 26801 26886 86 - 1.153 1.287 0.474
ENSG00000226210 E039 12.7684345 0.0521275635 2.313519e-01 3.640971e-01 12 26887 26915 29 - 0.896 1.103 0.764
ENSG00000226210 E040 10.2045507 0.0906526069 3.513078e-01 4.955269e-01 12 26916 26954 39 - 0.799 1.015 0.822
ENSG00000226210 E041 1.0403321 0.0437464847 1.078638e-01 2.023729e-01 12 26955 27040 86 - 0.494 0.203 -1.827
ENSG00000226210 E042 0.0000000       12 27281 27345 65 -      
ENSG00000226210 E043 0.0000000       12 31319 31347 29 -      
ENSG00000226210 E044 0.1451727 0.0442178463 1.792657e-01   12 31348 31374 27 - 0.184 0.000 -12.473
ENSG00000226210 E045 18.7923333 0.0895744032 1.123994e-02 3.173875e-02 12 31375 31651 277 - 0.833 1.299 1.703
ENSG00000226210 E046 0.3729606 0.0299176262 4.762042e-01 6.148629e-01 12 31878 32015 138 - 0.184 0.079 -1.398