ENSG00000225484

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000661316 ENSG00000225484 HEK293_OSMI2_2hA HEK293_TMG_2hB NUTM2B-AS1 lncRNA lncRNA 18.81855 25.53828 17.20626 0.2673517 0.3191614 -0.5694543 2.490482 4.082236 0.9332962 0.2309865 0.1938254 -2.1171067 0.1310500 0.1600667 0.05443333 -0.10563333 0.0003631986 0.0003631986   FALSE
ENST00000662025 ENSG00000225484 HEK293_OSMI2_2hA HEK293_TMG_2hB NUTM2B-AS1 lncRNA lncRNA 18.81855 25.53828 17.20626 0.2673517 0.3191614 -0.5694543 3.801402 5.200549 3.2346424 0.2504093 0.2437221 -0.6833760 0.2014583 0.2036000 0.18843333 -0.01516667 0.8155024476 0.0003631986   FALSE
MSTRG.4261.22 ENSG00000225484 HEK293_OSMI2_2hA HEK293_TMG_2hB NUTM2B-AS1 lncRNA   18.81855 25.53828 17.20626 0.2673517 0.3191614 -0.5694543 4.273905 5.170737 4.8193567 0.3781935 0.4952952 -0.1013262 0.2287875 0.2026667 0.27943333 0.07676667 0.1859894533 0.0003631986   FALSE
MSTRG.4261.25 ENSG00000225484 HEK293_OSMI2_2hA HEK293_TMG_2hB NUTM2B-AS1 lncRNA   18.81855 25.53828 17.20626 0.2673517 0.3191614 -0.5694543 4.198683 6.521106 3.2904999 0.6993445 0.1652400 -0.9846428 0.2183417 0.2548333 0.19166667 -0.06316667 0.2555601055 0.0003631986   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000225484 E001 14.2866087 0.0012572962 2.905672e-08 3.279150e-07 10 79661394 79663087 1694 - 1.423 0.928 -1.772
ENSG00000225484 E002 3.6397722 0.0422730015 5.081493e-04 2.190434e-03 10 79663088 79663234 147 - 0.945 0.359 -2.605
ENSG00000225484 E003 2.9934049 0.0498127953 1.082125e-03 4.242834e-03 10 79665497 79665594 98 - 0.880 0.306 -2.687
ENSG00000225484 E004 0.8105550 0.0149553540 6.416201e-02 1.336293e-01 10 79667997 79668385 389 - 0.422 0.100 -2.674
ENSG00000225484 E005 3.0332475 0.0090736842 3.147670e-06 2.343644e-05 10 79668386 79668452 67 - 0.924 0.180 -3.846
ENSG00000225484 E006 5.4627397 0.0031016439 2.667716e-14 8.237828e-13 10 79685150 79685180 31 - 1.199 0.099 -5.846
ENSG00000225484 E007 6.7537635 0.0024202699 2.101999e-14 6.596280e-13 10 79685181 79685257 77 - 1.262 0.249 -4.483
ENSG00000225484 E008 10.4126762 0.0140383270 6.236655e-13 1.582316e-11 10 79685258 79685383 126 - 1.403 0.521 -3.385
ENSG00000225484 E009 14.1115469 0.0012255144 1.673669e-20 1.136050e-18 10 79686282 79686461 180 - 1.530 0.638 -3.297
ENSG00000225484 E010 2.8974733 0.1899774824 3.427535e-01 4.867807e-01 10 79691500 79691501 2 - 0.710 0.507 -0.902
ENSG00000225484 E011 3.1940597 0.2516169348 4.663386e-01 6.058969e-01 10 79691502 79691503 2 - 0.710 0.562 -0.641
ENSG00000225484 E012 15.4249981 0.0011873173 6.492788e-03 1.990322e-02 10 79691504 79691621 118 - 1.020 1.267 0.888
ENSG00000225484 E013 34.3270169 0.0008305447 1.416806e-02 3.860509e-02 10 79691622 79691675 54 - 1.430 1.577 0.505
ENSG00000225484 E014 35.3559611 0.0055726111 7.181720e-02 1.463702e-01 10 79691676 79691692 17 - 1.462 1.584 0.416
ENSG00000225484 E015 76.2109049 0.0030731843 5.672934e-02 1.209985e-01 10 79691693 79691826 134 - 1.811 1.898 0.292
ENSG00000225484 E016 114.9447787 0.0006209140 3.338856e-02 7.855252e-02 10 79691827 79692056 230 - 2.001 2.067 0.223
ENSG00000225484 E017 0.2214452 0.0386691075 7.207203e-01   10 79714430 79714492 63 - 0.000 0.100 10.542
ENSG00000225484 E018 0.7697675 0.0673282110 5.628244e-01 6.903688e-01 10 79716445 79716482 38 - 0.150 0.250 0.924
ENSG00000225484 E019 1.1331762 0.1405870147 2.807187e-01 4.205885e-01 10 79716483 79716493 11 - 0.150 0.365 1.678
ENSG00000225484 E020 1.2846917 0.0847263281 5.865568e-01 7.101118e-01 10 79716494 79716496 3 - 0.261 0.363 0.666
ENSG00000225484 E021 2.6561527 0.0113138059 6.537097e-01 7.641028e-01 10 79716497 79716499 3 - 0.485 0.554 0.327
ENSG00000225484 E022 2.8044459 0.0060248757 5.247819e-01 6.582254e-01 10 79716500 79716506 7 - 0.485 0.584 0.463
ENSG00000225484 E023 4.0577896 0.0049202743 3.989183e-01 5.426646e-01 10 79716507 79716520 14 - 0.589 0.710 0.519
ENSG00000225484 E024 8.7547468 0.0257102614 5.260810e-02 1.138021e-01 10 79716521 79716603 83 - 0.774 1.035 0.993
ENSG00000225484 E025 7.1169029 0.0023485934 5.087853e-02 1.107372e-01 10 79716604 79716631 28 - 0.709 0.953 0.957
ENSG00000225484 E026 2.2487236 0.0077782508 9.688204e-01 9.844889e-01 10 79716632 79716671 40 - 0.485 0.486 0.004
ENSG00000225484 E027 61.3085821 0.0856876496 8.362290e-02 1.652130e-01 10 79716672 79722932 6261 - 1.896 1.695 -0.680
ENSG00000225484 E028 7.3525353 0.0025292457 8.857890e-01 9.309645e-01 10 79722933 79723317 385 - 0.924 0.900 -0.092
ENSG00000225484 E029 4.8629574 0.0035212664 2.551512e-01 3.919849e-01 10 79723318 79723442 125 - 0.633 0.789 0.647
ENSG00000225484 E030 11.7618278 0.0136461878 4.179680e-01 5.612847e-01 10 79723443 79723654 212 - 1.020 1.102 0.301
ENSG00000225484 E031 19.7703269 0.0130915509 5.534976e-02 1.185953e-01 10 79723915 79724012 98 - 1.164 1.343 0.629
ENSG00000225484 E032 1.1018559 0.0131114115 8.333277e-01 8.955923e-01 10 79724013 79724038 26 - 0.349 0.307 -0.262
ENSG00000225484 E033 0.1482932 0.0412484337 7.236781e-01   10 79745944 79746059 116 - 0.000 0.099 10.521
ENSG00000225484 E034 0.0000000       10 79762710 79762820 111 -      
ENSG00000225484 E035 35.3225563 0.0006378064 5.062162e-01 6.418869e-01 10 79762821 79765788 2968 - 1.566 1.518 -0.164
ENSG00000225484 E036 5.1271793 0.0032790328 6.969662e-01 7.972115e-01 10 79765789 79765795 7 - 0.742 0.789 0.186
ENSG00000225484 E037 65.8756994 0.0050197603 5.758032e-11 1.057735e-09 10 79765796 79766270 475 - 1.509 1.899 1.323
ENSG00000225484 E038 91.6257575 0.0021612775 2.581741e-01 3.954010e-01 10 79766271 79766289 19 - 1.914 1.953 0.132
ENSG00000225484 E039 112.6200029 0.0004996748 2.064484e-01 3.342681e-01 10 79766290 79766324 35 - 2.006 2.041 0.119
ENSG00000225484 E040 3.2196256 0.1538413456 1.271554e-01 2.301707e-01 10 79785818 79786443 626 - 0.349 0.706 1.727
ENSG00000225484 E041 17.0795875 0.0147826452 2.895759e-03 9.958302e-03 10 79795691 79797388 1698 - 1.410 1.115 -1.037
ENSG00000225484 E042 1.7232285 0.0083466593 2.025264e-01 3.293703e-01 10 79797389 79797704 316 - 0.261 0.486 1.324
ENSG00000225484 E043 0.0000000       10 79797705 79797707 3 -      
ENSG00000225484 E044 24.5919630 0.0007967782 2.210569e-01 3.516784e-01 10 79797708 79798027 320 - 1.334 1.414 0.280
ENSG00000225484 E045 1.5362266 0.0693175696 7.452077e-01 8.333227e-01 10 79801950 79802003 54 - 0.349 0.407 0.331
ENSG00000225484 E046 9.1155163 0.0091359223 4.194038e-01 5.626552e-01 10 79802709 79802958 250 - 0.924 1.012 0.325
ENSG00000225484 E047 0.5922303 0.0179879089 1.477520e-01 2.586339e-01 10 79803863 79804056 194 - 0.349 0.099 -2.262
ENSG00000225484 E048 0.3697384 0.0274424043 3.496327e-01 4.938442e-01 10 79804057 79804190 134 - 0.000 0.180 11.589
ENSG00000225484 E049 0.5483223 0.0213891979 8.485269e-01 9.059611e-01 10 79804191 79804484 294 - 0.150 0.181 0.327
ENSG00000225484 E050 162.2273369 0.0003468419 1.289785e-02 3.567511e-02 10 79804485 79804527 43 - 2.146 2.209 0.211
ENSG00000225484 E051 200.5427925 0.0009761166 5.848141e-02 1.240330e-01 10 79806039 79806122 84 - 2.251 2.295 0.147
ENSG00000225484 E052 0.9597906 0.0169836863 2.452626e-01 3.803459e-01 10 79806123 79806182 60 - 0.150 0.359 1.642
ENSG00000225484 E053 75.1985870 0.0023477899 4.609527e-01 6.009336e-01 10 79808759 79808762 4 - 1.885 1.841 -0.147
ENSG00000225484 E054 143.5841017 0.0002813914 3.988431e-01 5.425902e-01 10 79808763 79808832 70 - 2.160 2.127 -0.112
ENSG00000225484 E055 16.2734525 0.0062826083 6.698898e-01 7.765272e-01 10 79808833 79808963 131 - 1.252 1.208 -0.157
ENSG00000225484 E056 3.0603399 0.0070059979 5.914149e-03 1.838460e-02 10 79808964 79812112 3149 - 0.830 0.405 -1.900
ENSG00000225484 E057 0.1515154 0.0424314368 3.199105e-01   10 79812113 79812177 65 - 0.150 0.000 -12.454
ENSG00000225484 E058 0.0000000       10 79812178 79812427 250 -      
ENSG00000225484 E059 180.9326361 0.0002243686 6.953520e-01 7.959775e-01 10 79814613 79814716 104 - 2.250 2.231 -0.062
ENSG00000225484 E060 0.8114855 0.2385589714 4.921855e-01 6.293862e-01 10 79825288 79825790 503 - 0.349 0.181 -1.255
ENSG00000225484 E061 136.8814751 0.0002469027 1.162595e-03 4.514156e-03 10 79826198 79830576 4379 - 2.183 2.077 -0.354