ENSG00000225177

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000428044 ENSG00000225177 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 10.75171 18.56747 7.833959 0.3736421 0.1993573 -1.2439 2.1002807 2.4618702 1.6477073 0.62919898 0.31331701 -0.5764137 0.25039583 0.13250000 0.20876667 0.07626667 4.545258e-01 2.620238e-09 FALSE FALSE
ENST00000432673 ENSG00000225177 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 10.75171 18.56747 7.833959 0.3736421 0.1993573 -1.2439 0.6758259 1.0231881 0.2766927 0.19674292 0.12559213 -1.8495259 0.07578750 0.05550000 0.03573333 -0.01976667 6.293798e-01 2.620238e-09 FALSE FALSE
ENST00000664532 ENSG00000225177 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 10.75171 18.56747 7.833959 0.3736421 0.1993573 -1.2439 0.5044367 0.2005508 0.4497464 0.05359136 0.05595161 1.1266699 0.06962083 0.01070000 0.05736667 0.04666667 3.144029e-05 2.620238e-09 FALSE FALSE
MSTRG.29036.1 ENSG00000225177 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   10.75171 18.56747 7.833959 0.3736421 0.1993573 -1.2439 0.4346281 0.3699081 1.2080407 0.10565048 0.26135723 1.6808398 0.04770000 0.01983333 0.15520000 0.13536667 3.795538e-05 2.620238e-09 FALSE FALSE
MSTRG.29036.3 ENSG00000225177 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   10.75171 18.56747 7.833959 0.3736421 0.1993573 -1.2439 2.6220409 5.0687496 2.2229816 1.11697382 0.28738239 -1.1855020 0.21198750 0.27336667 0.28393333 0.01056667 9.604752e-01 2.620238e-09 FALSE FALSE
MSTRG.29036.4 ENSG00000225177 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   10.75171 18.56747 7.833959 0.3736421 0.1993573 -1.2439 1.9304510 5.7774260 0.0000000 1.63406174 0.00000000 -9.1767780 0.11314167 0.30996667 0.00000000 -0.30996667 2.620238e-09 2.620238e-09 FALSE FALSE
MSTRG.29036.5 ENSG00000225177 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   10.75171 18.56747 7.833959 0.3736421 0.1993573 -1.2439 1.6153699 2.4288269 1.4726459 1.28228692 0.51275050 -0.7180133 0.15907083 0.13053333 0.18833333 0.05780000 8.149950e-01 2.620238e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000225177 E001 5.568065 0.0037864142 7.654740e-08 7.950480e-07 6 138691696 138691803 108 + 1.157 0.466 -2.792
ENSG00000225177 E002 8.520707 0.0030619868 9.039401e-09 1.123458e-07 6 138691804 138691956 153 + 1.296 0.666 -2.369
ENSG00000225177 E003 1.071553 0.0907476426 1.864006e-01 3.092288e-01 6 138691957 138691968 12 + 0.474 0.214 -1.635
ENSG00000225177 E004 16.460190 0.0552898491 1.618581e-01 2.775537e-01 6 138692499 138692546 48 + 1.317 1.132 -0.655
ENSG00000225177 E005 16.157159 0.0570479611 2.221138e-01 3.529301e-01 6 138692547 138692547 1 + 1.296 1.132 -0.580
ENSG00000225177 E006 28.449399 0.0052400282 6.051762e-01 7.255948e-01 6 138692548 138692617 70 + 1.450 1.399 -0.178
ENSG00000225177 E007 6.432123 0.0029657844 8.721642e-03 2.559109e-02 6 138694319 138694389 71 + 1.037 0.705 -1.281
ENSG00000225177 E008 4.815269 0.0156279605 1.600107e-02 4.273606e-02 6 138694390 138694392 3 + 0.950 0.601 -1.404
ENSG00000225177 E009 58.103845 0.0008304681 3.671672e-01 5.115591e-01 6 138694393 138694547 155 + 1.690 1.721 0.107
ENSG00000225177 E010 11.988097 0.0042798788 2.742825e-09 3.752852e-08 6 138694949 138696367 1419 + 1.402 0.818 -2.121
ENSG00000225177 E011 5.421867 0.0066526796 8.691147e-02 1.704499e-01 6 138696368 138696596 229 + 0.925 0.686 -0.945
ENSG00000225177 E012 104.175776 0.0004495376 1.681387e-03 6.223429e-03 6 138696597 138696755 159 + 1.890 1.989 0.331
ENSG00000225177 E013 9.460244 0.0019273283 4.018631e-02 9.138040e-02 6 138696756 138696902 147 + 0.774 1.018 0.931
ENSG00000225177 E014 43.062578 0.0006363068 1.857789e-01 3.084786e-01 6 138696903 138696994 92 + 1.546 1.609 0.215
ENSG00000225177 E015 120.035045 0.0004183391 1.778407e-06 1.398679e-05 6 138696995 138697306 312 + 1.920 2.064 0.483