ENSG00000225151

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000559668 ENSG00000225151 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA2P7 transcribed_unprocessed_pseudogene processed_transcript 65.56298 96.24278 34.80254 6.603083 0.9214651 -1.467221 34.219238 47.484109 18.498081 3.2618456 0.71973626 -1.3595932 0.52573750 0.49386667 0.53116667 0.0373 0.50258774 3.456366e-17 FALSE  
ENST00000561015 ENSG00000225151 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA2P7 transcribed_unprocessed_pseudogene processed_transcript 65.56298 96.24278 34.80254 6.603083 0.9214651 -1.467221 4.958295 4.778459 2.440817 0.3408467 0.03806391 -0.9662986 0.08157917 0.04976667 0.07026667 0.0205 0.05597111 3.456366e-17 TRUE  
MSTRG.11430.1 ENSG00000225151 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA2P7 transcribed_unprocessed_pseudogene   65.56298 96.24278 34.80254 6.603083 0.9214651 -1.467221 18.196464 33.652686 8.794894 3.1057839 0.35849876 -1.9347727 0.25565833 0.35003333 0.25313333 -0.0969 0.04719272 3.456366e-17 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000225151 E001 5.1459093 0.0034087372 0.0003186055 0.0014552916 15 84199098 84199244 147 - 0.172 0.824 3.539
ENSG00000225151 E002 3.1281722 0.0357003173 0.0214606045 0.0545607271 15 84199245 84199301 57 - 0.172 0.635 2.766
ENSG00000225151 E003 1.4360922 0.0216554791 0.2244017643 0.3556914411 15 84199302 84199310 9 - 0.172 0.402 1.645
ENSG00000225151 E004 0.9578015 0.0864150629 0.6087466546 0.7283851921 15 84199311 84199311 1 - 0.172 0.274 0.855
ENSG00000225151 E005 72.9355910 0.0006250660 0.0001910045 0.0009254773 15 84199312 84200876 1565 - 1.670 1.838 0.568
ENSG00000225151 E006 0.0000000       15 84200877 84200880 4 -      
ENSG00000225151 E007 0.0000000       15 84200881 84200960 80 -      
ENSG00000225151 E008 3.6556867 0.0049102262 0.1636873238 0.2799384220 15 84200961 84201208 248 - 0.769 0.557 -0.901
ENSG00000225151 E009 0.0000000       15 84201209 84201347 139 -      
ENSG00000225151 E010 0.1482932 0.0652468815 1.0000000000   15 84201348 84201633 286 - 0.000 0.085 10.148
ENSG00000225151 E011 0.0000000       15 84201634 84201656 23 -      
ENSG00000225151 E012 0.4428904 0.2017704970 0.5760139591 0.7015282126 15 84201657 84201835 179 - 0.000 0.160 10.851
ENSG00000225151 E013 0.9890372 0.0126995998 0.3399163254 0.4838503588 15 84201836 84202708 873 - 0.391 0.218 -1.163
ENSG00000225151 E014 1.1728179 0.0116692421 0.5142759986 0.6489979473 15 84202709 84202728 20 - 0.391 0.272 -0.748
ENSG00000225151 E015 4.1515943 0.0120722579 0.5046970239 0.6405910375 15 84202729 84202801 73 - 0.731 0.631 -0.422
ENSG00000225151 E016 4.9955606 0.0182338136 0.1345039584 0.2404109484 15 84202802 84202869 68 - 0.865 0.654 -0.854
ENSG00000225151 E017 96.4703415 0.0087597697 0.2904670726 0.4312784832 15 84202870 84203007 138 - 1.948 1.919 -0.098
ENSG00000225151 E018 70.6683385 0.0004600488 0.0232165009 0.0581939195 15 84203008 84203020 13 - 1.852 1.756 -0.324
ENSG00000225151 E019 0.0000000       15 84203866 84204086 221 -      
ENSG00000225151 E020 5.1659737 0.0036649155 0.6866573836 0.7891411356 15 84204177 84204181 5 - 0.690 0.746 0.230
ENSG00000225151 E021 6.9591451 0.0025720742 0.2718332705 0.4106403655 15 84204182 84204331 150 - 0.731 0.877 0.575
ENSG00000225151 E022 76.1010244 0.0003738306 0.0836902982 0.1653273380 15 84204426 84204516 91 - 1.870 1.798 -0.240
ENSG00000225151 E023 3.3560922 0.0186454317 0.1511347409 0.2632176219 15 84204517 84204599 83 - 0.731 0.504 -1.002
ENSG00000225151 E024 22.1911779 0.0035328725 0.8674882334 0.9188105183 15 84204600 84204691 92 - 1.301 1.310 0.031
ENSG00000225151 E025 16.5922012 0.0290011375 0.4814169195 0.6196402614 15 84204787 84204975 189 - 1.136 1.209 0.260
ENSG00000225151 E026 4.5901417 0.0080556455 0.1837989134 0.3059821153 15 84205231 84205319 89 - 0.536 0.746 0.909
ENSG00000225151 E027 0.8416995 0.1321954998 0.1331094061 0.2384603088 15 84229852 84229901 50 - 0.000 0.318 12.148
ENSG00000225151 E028 2.6745125 0.1645734720 0.3960321472 0.5398084440 15 84229902 84230136 235 - 0.391 0.578 0.933