ENSG00000225096

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000420759 ENSG00000225096 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 4.234205 8.018236 3.304372 0.3153669 0.2083865 -1.276347 1.0033251 1.8321045 0.8174401 0.16905298 0.19899156 -1.1546281 0.24877083 0.2282000 0.2572000 0.0290000 9.494330e-01 2.609885e-09   FALSE
ENST00000662791 ENSG00000225096 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 4.234205 8.018236 3.304372 0.3153669 0.2083865 -1.276347 0.4915537 0.5029301 0.4377254 0.05786278 0.03763818 -0.1961481 0.12653750 0.0634000 0.1331000 0.0697000 4.871058e-02 2.609885e-09 FALSE FALSE
MSTRG.28453.4 ENSG00000225096 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   4.234205 8.018236 3.304372 0.3153669 0.2083865 -1.276347 1.1603910 2.1553846 0.5824474 0.37685944 0.12292841 -1.8698643 0.25845417 0.2662667 0.1728667 -0.0934000 3.659533e-01 2.609885e-09   FALSE
MSTRG.28453.5 ENSG00000225096 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   4.234205 8.018236 3.304372 0.3153669 0.2083865 -1.276347 0.6461742 1.3343805 0.2745977 0.27858677 0.16243818 -2.2399457 0.14430417 0.1693000 0.0786000 -0.0907000 4.871975e-01 2.609885e-09   FALSE
MSTRG.28453.7 ENSG00000225096 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   4.234205 8.018236 3.304372 0.3153669 0.2083865 -1.276347 0.2122292 0.1981928 0.3954337 0.11597193 0.21317813 0.9615458 0.05357500 0.0259000 0.1123000 0.0864000 6.708467e-01 2.609885e-09   FALSE
MSTRG.28453.8 ENSG00000225096 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   4.234205 8.018236 3.304372 0.3153669 0.2083865 -1.276347 0.1765250 1.4122000 0.0000000 0.28254277 0.00000000 -7.1519806 0.02175833 0.1740667 0.0000000 -0.1740667 2.609885e-09 2.609885e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000225096 E001 0.0000000       6 57961438 57961456 19 +      
ENSG00000225096 E002 0.0000000       6 57961457 57961529 73 +      
ENSG00000225096 E003 1.2146601 0.0109105863 0.3712022957 0.515626183 6 57961530 57961552 23 + 0.181 0.348 1.251
ENSG00000225096 E004 2.7270249 0.0060539965 0.0324868456 0.076781010 6 57961553 57961602 50 + 0.181 0.588 2.475
ENSG00000225096 E005 8.1872310 0.0023532824 0.0026828988 0.009322513 6 57961603 57961630 28 + 0.554 0.983 1.736
ENSG00000225096 E006 19.2008431 0.0010715620 0.0096428128 0.027886274 6 57961631 57961647 17 + 1.054 1.289 0.837
ENSG00000225096 E007 20.6242761 0.0009768822 0.0052539963 0.016621769 6 57961648 57961656 9 + 1.074 1.320 0.875
ENSG00000225096 E008 46.7385072 0.0005878831 0.0500613778 0.109275007 6 57961657 57961724 68 + 1.539 1.642 0.351
ENSG00000225096 E009 40.9397969 0.0008761463 0.2350730550 0.368435342 6 57961725 57961742 18 + 1.512 1.576 0.220
ENSG00000225096 E010 6.1582517 0.0029532593 0.0021671323 0.007741554 6 57961743 57962077 335 + 1.054 0.671 -1.486
ENSG00000225096 E011 2.1369621 0.0079261666 0.7339806138 0.825065761 6 57962078 57962124 47 + 0.487 0.422 -0.331
ENSG00000225096 E012 1.5563746 0.0104683640 0.3242542588 0.467620725 6 57962125 57962130 6 + 0.487 0.307 -1.010
ENSG00000225096 E013 5.5594868 0.0030958787 0.5667480365 0.693649104 6 57962131 57962177 47 + 0.825 0.741 -0.333
ENSG00000225096 E014 5.2692431 0.0035342108 0.4205379010 0.563741526 6 57962178 57962180 3 + 0.825 0.708 -0.470
ENSG00000225096 E015 24.6451685 0.0011488653 0.6064489886 0.726590491 6 57962181 57962248 68 + 1.385 1.340 -0.154
ENSG00000225096 E016 2.4721710 0.0062160039 0.6986245295 0.798543989 6 57965517 57965665 149 + 0.554 0.484 -0.334
ENSG00000225096 E017 1.7712641 0.6990510978 0.6977697868 0.797817568 6 57965666 57965743 78 + 0.612 0.305 -1.603
ENSG00000225096 E018 0.1472490 0.0442993885 0.1946917131   6 57965744 57965946 203 + 0.181 0.000 -12.996
ENSG00000225096 E019 0.1515154 0.0415626244 0.1947210958   6 57971591 57971594 4 + 0.181 0.000 -13.007
ENSG00000225096 E020 49.0389800 0.0016897476 0.1295601180 0.233537352 6 57971595 57971656 62 + 1.576 1.654 0.265
ENSG00000225096 E021 1.2952903 0.0108799507 0.0075203743 0.022566126 6 57971657 57972077 421 + 0.613 0.149 -2.917
ENSG00000225096 E022 67.2422157 0.0006707703 0.0006511197 0.002719784 6 57972094 57973138 1045 + 1.874 1.725 -0.504
ENSG00000225096 E023 33.0544255 0.0142804576 0.7721020795 0.852905397 6 57973139 57973690 552 + 1.491 1.465 -0.090
ENSG00000225096 E024 1.2983090 0.0110567476 0.5959482667 0.717955214 6 58027672 58027723 52 + 0.407 0.306 -0.598
ENSG00000225096 E025 0.2214452 0.0375396380 1.0000000000   6 58028162 58028205 44 + 0.000 0.081 10.329
ENSG00000225096 E026 0.0000000       6 58038433 58038435 3 +      
ENSG00000225096 E027 0.0000000       6 58038436 58038465 30 +      
ENSG00000225096 E028 0.0000000       6 58038466 58038467 2 +      
ENSG00000225096 E029 0.0000000       6 58038468 58038489 22 +      
ENSG00000225096 E030 0.0000000       6 58038490 58038556 67 +      
ENSG00000225096 E031 1.4874915 0.0098330557 0.0008902728 0.003580045 6 58043435 58043527 93 + 0.710 0.149 -3.335
ENSG00000225096 E032 0.1482932 0.0409544343 1.0000000000   6 58072215 58072267 53 + 0.000 0.081 10.316
ENSG00000225096 E033 0.2934659 0.0300637852 0.5059993494   6 58091904 58092113 210 + 0.181 0.081 -1.336
ENSG00000225096 E034 0.6213751 0.0200430226 0.0586826121 0.124376229 6 58095771 58096509 739 + 0.406 0.081 -2.918
ENSG00000225096 E035 0.5901540 0.0204244370 0.0584641949 0.124003474 6 58162610 58162749 140 + 0.406 0.081 -2.920
ENSG00000225096 E036 0.7374030 0.0159380846 0.0186471730 0.048558776 6 58178605 58178992 388 + 0.487 0.081 -3.335
ENSG00000225096 E037 0.1515154 0.0415626244 0.1947210958   6 58187226 58188234 1009 + 0.181 0.000 -13.007
ENSG00000225096 E038 0.0000000       6 58300739 58300811 73 +      
ENSG00000225096 E039 0.1451727 0.0445691122 0.1945715980   6 58310296 58310417 122 + 0.181 0.000 -12.995
ENSG00000225096 E040 0.0000000       6 58325486 58325548 63 +      
ENSG00000225096 E041 0.0000000       6 58331520 58332065 546 +      
ENSG00000225096 E042 0.0000000       6 58355145 58355198 54 +      
ENSG00000225096 E043 0.0000000       6 58355766 58357523 1758 +      
ENSG00000225096 E044 0.0000000       6 58436559 58436704 146 +      
ENSG00000225096 E045 0.0000000       6 58437244 58438364 1121 +