ENSG00000224940

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000446477 ENSG00000224940 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRT4 protein_coding protein_coding 2.609919 3.988381 2.011015 0.5524798 0.2164884 -0.9843361 0.5705189 0.4660698 0.5910028 0.09968836 0.06814304 0.3361986 0.2161042 0.1158000 0.3071 0.19130000 3.091220e-02 8.68405e-10 FALSE TRUE
ENST00000480290 ENSG00000224940 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRT4 protein_coding protein_coding 2.609919 3.988381 2.011015 0.5524798 0.2164884 -0.9843361 0.4389349 0.9997331 0.0000000 0.23569218 0.00000000 -6.6578302 0.1511667 0.2427333 0.0000 -0.24273333 8.684050e-10 8.68405e-10 FALSE TRUE
ENST00000489517 ENSG00000224940 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRT4 protein_coding protein_coding 2.609919 3.988381 2.011015 0.5524798 0.2164884 -0.9843361 0.5275448 0.7483116 0.4264820 0.23937457 0.12540051 -0.7968685 0.2009083 0.1768667 0.2059 0.02903333 8.947592e-01 8.68405e-10 FALSE TRUE
ENST00000489835 ENSG00000224940 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRT4 protein_coding protein_coding 2.609919 3.988381 2.011015 0.5524798 0.2164884 -0.9843361 1.0729208 1.7742664 0.9935298 0.08352993 0.16607051 -0.8302476 0.4318125 0.4645667 0.4870 0.02243333 9.370101e-01 8.68405e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000224940 E001 0.000000       7 128350325 128350325 1 -      
ENSG00000224940 E002 1.538404 0.0138741958 0.96312866 0.98071563 7 128350326 128350353 28 - 0.372 0.382 0.059
ENSG00000224940 E003 54.065525 0.0042743603 0.01097584 0.03110595 7 128350354 128350855 502 - 1.590 1.739 0.506
ENSG00000224940 E004 32.705596 0.0133095130 0.12027471 0.22037510 7 128350856 128351024 169 - 1.396 1.525 0.444
ENSG00000224940 E005 41.775392 0.0085574299 0.20478994 0.33213059 7 128351025 128351414 390 - 1.513 1.615 0.347
ENSG00000224940 E006 14.410997 0.0067462612 0.92088651 0.95410051 7 128351415 128351678 264 - 1.134 1.152 0.063
ENSG00000224940 E007 5.891741 0.0027771612 0.02160164 0.05485451 7 128351679 128352116 438 - 0.981 0.698 -1.102
ENSG00000224940 E008 12.312430 0.0820899682 0.43840092 0.58028841 7 128352117 128352448 332 - 1.136 1.054 -0.296
ENSG00000224940 E009 31.144775 0.0008021709 0.97895765 0.99087766 7 128352449 128352678 230 - 1.462 1.465 0.012
ENSG00000224940 E010 22.147176 0.0010234811 0.64285079 0.75555348 7 128358681 128358737 57 - 1.346 1.317 -0.104
ENSG00000224940 E011 22.530810 0.0009337851 0.20938787 0.33780618 7 128358738 128358800 63 - 1.388 1.302 -0.302
ENSG00000224940 E012 23.062227 0.0009984240 0.17225034 0.29113636 7 128359149 128359253 105 - 1.396 1.302 -0.328
ENSG00000224940 E013 13.490867 0.0019435254 0.77494934 0.85498377 7 128359340 128359374 35 - 1.089 1.122 0.117
ENSG00000224940 E014 54.356855 0.0007239518 0.38229221 0.52652170 7 128359375 128360063 689 - 1.719 1.684 -0.121
ENSG00000224940 E015 8.391153 0.0022031505 0.11532194 0.21332014 7 128361306 128361422 117 - 1.038 0.866 -0.645
ENSG00000224940 E016 5.329684 0.0033335511 0.86438043 0.91657961 7 128361423 128361560 138 - 0.775 0.756 -0.078
ENSG00000224940 E017 4.277150 0.0039613571 0.01446703 0.03928464 7 128361561 128361711 151 - 0.890 0.554 -1.389