ENSG00000224597

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000427063 ENSG00000224597 HEK293_OSMI2_2hA HEK293_TMG_2hB SVIL-AS1 transcribed_unprocessed_pseudogene processed_transcript 11.46008 12.61895 11.19199 1.156277 0.288472 -0.1729797 1.4148528 1.1006210 1.4307717 0.23029399 0.30135805 0.3754751 0.12317500 0.08526667 0.12680000 0.041533333 0.5180905444 2.60995e-07 FALSE TRUE
ENST00000438202 ENSG00000224597 HEK293_OSMI2_2hA HEK293_TMG_2hB SVIL-AS1 transcribed_unprocessed_pseudogene processed_transcript 11.46008 12.61895 11.19199 1.156277 0.288472 -0.1729797 1.0660631 0.8258970 0.9954979 0.09735213 0.16217220 0.2665130 0.09561667 0.06573333 0.08863333 0.022900000 0.5401094975 2.60995e-07   FALSE
ENST00000623175 ENSG00000224597 HEK293_OSMI2_2hA HEK293_TMG_2hB SVIL-AS1 transcribed_unprocessed_pseudogene processed_transcript 11.46008 12.61895 11.19199 1.156277 0.288472 -0.1729797 1.9372639 1.4480159 2.9142717 0.21816962 0.55714312 1.0040709 0.17149583 0.11383333 0.26273333 0.148900000 0.0420470653 2.60995e-07 FALSE TRUE
ENST00000686070 ENSG00000224597 HEK293_OSMI2_2hA HEK293_TMG_2hB SVIL-AS1 transcribed_unprocessed_pseudogene processed_transcript 11.46008 12.61895 11.19199 1.156277 0.288472 -0.1729797 1.1635518 1.1101037 0.9944962 0.23097329 0.05422486 -0.1571602 0.10382917 0.08670000 0.08923333 0.002533333 0.9889142969 2.60995e-07   FALSE
MSTRG.3733.11 ENSG00000224597 HEK293_OSMI2_2hA HEK293_TMG_2hB SVIL-AS1 transcribed_unprocessed_pseudogene   11.46008 12.61895 11.19199 1.156277 0.288472 -0.1729797 0.8808844 2.1031653 0.3490752 0.66011299 0.34907519 -2.5570477 0.07333750 0.17900000 0.02996667 -0.149033333 0.1290999831 2.60995e-07   FALSE
MSTRG.3733.13 ENSG00000224597 HEK293_OSMI2_2hA HEK293_TMG_2hB SVIL-AS1 transcribed_unprocessed_pseudogene   11.46008 12.61895 11.19199 1.156277 0.288472 -0.1729797 2.3887296 3.5033505 1.1536403 0.70862362 0.11096498 -1.5942023 0.20265833 0.27190000 0.10346667 -0.168433333 0.0001619483 2.60995e-07   FALSE
MSTRG.3733.3 ENSG00000224597 HEK293_OSMI2_2hA HEK293_TMG_2hB SVIL-AS1 transcribed_unprocessed_pseudogene   11.46008 12.61895 11.19199 1.156277 0.288472 -0.1729797 0.6579679 0.9945757 0.9514685 0.10690032 0.15447788 -0.0632748 0.05766250 0.08166667 0.08550000 0.003833333 0.9524053668 2.60995e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000224597 E001 0.0000000       10 29409402 29409503 102 +      
ENSG00000224597 E002 0.0000000       10 29409504 29409508 5 +      
ENSG00000224597 E003 0.7300267 0.1073880103 3.088666e-01 4.511275e-01 10 29409509 29409533 25 + 0.121 0.300 1.626
ENSG00000224597 E004 0.9117310 0.2473417526 2.241277e-01 3.553433e-01 10 29409534 29409545 12 + 0.121 0.369 2.057
ENSG00000224597 E005 2.9788651 0.1838158428 7.919340e-01 8.669070e-01 10 29409546 29409553 8 + 0.554 0.611 0.256
ENSG00000224597 E006 2.9788651 0.1838158428 7.919340e-01 8.669070e-01 10 29409554 29409556 3 + 0.554 0.611 0.256
ENSG00000224597 E007 14.3831429 0.0012778093 2.369081e-01 3.705939e-01 10 29409557 29409579 23 + 1.133 1.233 0.354
ENSG00000224597 E008 26.0078417 0.0007886753 2.282202e-03 8.096701e-03 10 29409580 29409601 22 + 1.315 1.516 0.694
ENSG00000224597 E009 45.0293934 0.0005616858 2.749793e-03 9.520623e-03 10 29409602 29409658 57 + 1.581 1.728 0.501
ENSG00000224597 E010 21.5431888 0.0015148792 1.675183e-01 2.849638e-01 10 29409659 29409683 25 + 1.295 1.392 0.338
ENSG00000224597 E011 1.6910544 0.0118583207 3.492041e-02 8.150061e-02 10 29410243 29410461 219 + 0.591 0.219 -2.144
ENSG00000224597 E012 57.2895062 0.0005795414 4.375773e-02 9.794616e-02 10 29415357 29415412 56 + 1.718 1.804 0.289
ENSG00000224597 E013 0.1515154 0.0436409251 5.160197e-01   10 29418182 29418304 123 + 0.121 0.000 -9.484
ENSG00000224597 E014 43.3928542 0.0006692258 3.952818e-04 1.756296e-03 10 29420491 29420661 171 + 1.744 1.561 -0.622
ENSG00000224597 E015 25.4516750 0.0007813805 8.724372e-03 2.559712e-02 10 29420662 29420773 112 + 1.513 1.336 -0.612
ENSG00000224597 E016 143.4566613 0.0005479591 1.331353e-06 1.076671e-05 10 29420774 29422374 1601 + 2.230 2.102 -0.430
ENSG00000224597 E017 5.7559464 0.0029614512 4.557681e-01 5.962689e-01 10 29457651 29457881 231 + 0.891 0.796 -0.368
ENSG00000224597 E018 15.6183925 0.0092400967 6.083911e-01 7.281345e-01 10 29458274 29458520 247 + 1.200 1.240 0.144
ENSG00000224597 E019 9.9795353 0.0019121334 9.208740e-01 9.540952e-01 10 29458521 29458787 267 + 1.041 1.048 0.025
ENSG00000224597 E020 32.4703826 0.0024004599 4.952578e-03 1.579866e-02 10 29460385 29461146 762 + 1.433 1.608 0.598
ENSG00000224597 E021 17.9487131 0.0737428827 1.981133e-01 3.238567e-01 10 29467240 29468919 1680 + 1.365 1.203 -0.568
ENSG00000224597 E022 21.7861917 0.0011744672 8.146785e-08 8.419989e-07 10 29468920 29469130 211 + 1.101 1.507 1.424
ENSG00000224597 E023 20.0035477 0.0009929541 3.987518e-01 5.424943e-01 10 29482833 29485879 3047 + 1.360 1.295 -0.230
ENSG00000224597 E024 5.0531775 0.0221050792 8.601924e-02 1.690220e-01 10 29487155 29488960 1806 + 0.908 0.662 -0.983
ENSG00000224597 E025 2.1025318 0.0079270376 7.205689e-02 1.467522e-01 10 29492963 29493884 922 + 0.294 0.597 1.611
ENSG00000224597 E026 0.2998086 0.0281881798 1.000000e+00   10 29510428 29512266 1839 + 0.121 0.123 0.023