ENSG00000224043

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392929 ENSG00000224043 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.887998 3.330142 2.905256 0.3216779 0.2444335 -0.1962868 0.3050806 0.1619749 0.5068275 0.16197491 0.50682749 1.5874847 0.09618333 0.05800000 0.1508667 0.09286667 1.0000000 0.0030935   FALSE
ENST00000413962 ENSG00000224043 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.887998 3.330142 2.905256 0.3216779 0.2444335 -0.1962868 0.8915029 1.2602741 0.9737592 0.20405971 0.33896811 -0.3687628 0.32463333 0.39376667 0.3542333 -0.03953333 0.9037834 0.0030935 FALSE FALSE
ENST00000428857 ENSG00000224043 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.887998 3.330142 2.905256 0.3216779 0.2444335 -0.1962868 0.5892441 0.3400657 0.7285867 0.01420050 0.05605159 1.0771416 0.21725833 0.10473333 0.2519667 0.14723333 0.0030935 0.0030935 FALSE FALSE
ENST00000668300 ENSG00000224043 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.887998 3.330142 2.905256 0.3216779 0.2444335 -0.1962868 0.2492486 0.2949032 0.2268486 0.02169034 0.05291459 -0.3643863 0.08814583 0.08946667 0.0766000 -0.01286667 0.9302195 0.0030935   FALSE
MSTRG.19263.3 ENSG00000224043 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   2.887998 3.330142 2.905256 0.3216779 0.2444335 -0.1962868 0.7892604 1.2437742 0.4228113 0.63777776 0.42281129 -1.5344675 0.25144167 0.34426667 0.1492000 -0.19506667 0.5108643 0.0030935   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000224043 E001 0.3686942 0.0279183774 9.425451e-01 9.679385e-01 2 134735464 134735581 118 - 0.118 0.127 0.129
ENSG00000224043 E002 5.6241075 0.0031967713 9.766240e-02 1.869251e-01 2 134804101 134804743 643 - 0.703 0.911 0.819
ENSG00000224043 E003 2.9054991 0.0057364355 5.067656e-01 6.424287e-01 2 134810921 134811279 359 - 0.543 0.643 0.448
ENSG00000224043 E004 0.0000000       2 134841054 134841138 85 -      
ENSG00000224043 E005 0.8147197 0.0159818540 5.869802e-01 7.103992e-01 2 134845610 134846154 545 - 0.210 0.305 0.711
ENSG00000224043 E006 24.1612944 0.0010610083 3.265777e-03 1.104895e-02 2 134864600 134866541 1942 - 1.490 1.302 -0.651
ENSG00000224043 E007 15.6777194 0.0012817315 5.883607e-08 6.245135e-07 2 134866542 134867317 776 - 1.403 0.946 -1.635
ENSG00000224043 E008 7.6854706 0.0026147356 3.135922e-01 4.562034e-01 2 134867318 134867519 202 - 0.988 0.873 -0.432
ENSG00000224043 E009 25.7540359 0.0012617882 2.831733e-01 4.232652e-01 2 134867520 134867739 220 - 1.392 1.456 0.219
ENSG00000224043 E010 21.5433621 0.0009482289 3.399006e-03 1.143487e-02 2 134868944 134869041 98 - 1.243 1.440 0.684
ENSG00000224043 E011 6.0076536 0.0037830774 6.563479e-01 7.659663e-01 2 134877520 134877643 124 - 0.820 0.873 0.204
ENSG00000224043 E012 15.5034422 0.0013558967 1.014011e-03 4.007035e-03 2 134918563 134918710 148 - 1.064 1.330 0.945