ENSG00000224032

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000427306 ENSG00000224032 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 24.40805 37.76222 19.30933 0.2734439 0.1721125 -0.9672804 2.371657 3.166269 1.520721 0.37690091 0.18078433 -1.05312193 0.09875417 0.08383333 0.07870000 -0.005133333 9.419757e-01 1.753487e-08    
ENST00000663232 ENSG00000224032 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 24.40805 37.76222 19.30933 0.2734439 0.1721125 -0.9672804 1.185987 1.188546 1.241012 0.05444459 0.09357043 0.06181012 0.05030417 0.03146667 0.06426667 0.032800000 1.717572e-03 1.753487e-08    
ENST00000688370 ENSG00000224032 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 24.40805 37.76222 19.30933 0.2734439 0.1721125 -0.9672804 15.331463 26.294017 10.463321 1.18244251 0.61426252 -1.32856420 0.60554583 0.69633333 0.54250000 -0.153833333 5.406281e-02 1.753487e-08 TRUE  
ENST00000690733 ENSG00000224032 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 24.40805 37.76222 19.30933 0.2734439 0.1721125 -0.9672804 1.792195 1.696554 2.399606 0.08818777 0.16833254 0.49771136 0.08423333 0.04490000 0.12423333 0.079333333 1.753487e-08 1.753487e-08 TRUE  
MSTRG.26745.9 ENSG00000224032 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   24.40805 37.76222 19.30933 0.2734439 0.1721125 -0.9672804 1.390219 1.516653 2.024575 0.09176107 0.17195466 0.41435554 0.06661250 0.04013333 0.10496667 0.064833333 4.924352e-06 1.753487e-08 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000224032 E001 0.000000       5 112160526 112160528 3 +      
ENSG00000224032 E002 0.000000       5 112160529 112160590 62 +      
ENSG00000224032 E003 3.240893 0.0379370962 5.977404e-01 7.194680e-01 5 112160591 112160863 273 + 0.520 0.623 0.469
ENSG00000224032 E004 3.462338 0.0630989948 5.245252e-01 6.580340e-01 5 112160864 112160864 1 + 0.520 0.648 0.574
ENSG00000224032 E005 4.121289 0.0040930885 4.323602e-01 5.748196e-01 5 112160865 112160871 7 + 0.577 0.709 0.569
ENSG00000224032 E006 43.123075 0.0070866434 8.380356e-01 8.987503e-01 5 112160872 112160884 13 + 1.601 1.597 -0.013
ENSG00000224032 E007 273.819609 0.0082904612 1.532933e-01 2.661549e-01 5 112160885 112160991 107 + 2.341 2.416 0.250
ENSG00000224032 E008 623.894069 0.0006284903 2.600068e-04 1.216806e-03 5 112160992 112161295 304 + 2.705 2.773 0.226
ENSG00000224032 E009 16.530668 0.0011538751 5.852095e-05 3.240848e-04 5 112161296 112161484 189 + 1.407 1.087 -1.129
ENSG00000224032 E010 17.472778 0.0010489231 1.162574e-05 7.610701e-05 5 112161485 112161681 197 + 1.437 1.095 -1.205
ENSG00000224032 E011 6.510183 0.0368891755 6.232984e-03 1.922502e-02 5 112161682 112161685 4 + 1.066 0.674 -1.517
ENSG00000224032 E012 9.274674 0.0019610121 7.491207e-03 2.249000e-02 5 112161686 112161702 17 + 1.145 0.870 -1.015
ENSG00000224032 E013 314.381113 0.0034805500 1.434205e-03 5.420783e-03 5 112161703 112161775 73 + 2.374 2.490 0.388
ENSG00000224032 E014 16.835351 0.0085962879 1.651555e-05 1.044019e-04 5 112161776 112162150 375 + 1.452 1.076 -1.322
ENSG00000224032 E015 238.957546 0.0023928506 2.008824e-02 5.167372e-02 5 112162151 112162258 108 + 2.277 2.365 0.293
ENSG00000224032 E016 86.158456 0.0023883332 1.474601e-02 3.991809e-02 5 112162259 112162278 20 + 1.809 1.938 0.434
ENSG00000224032 E017 66.360756 0.0004057549 2.669260e-04 1.244967e-03 5 112162279 112162602 324 + 1.888 1.740 -0.500
ENSG00000224032 E018 82.648353 0.0049039633 2.827379e-44 1.248575e-41 5 112162603 112164858 2256 + 2.243 1.553 -2.326