ENSG00000223959

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423684 ENSG00000223959 HEK293_OSMI2_2hA HEK293_TMG_2hB AFG3L1P transcribed_unitary_pseudogene retained_intron 18.46252 15.70372 19.46768 0.3452278 0.7332785 0.3097972 3.7693483 4.9504656 4.6294348 0.65613814 0.94991197 -0.09652648 0.20820417 0.31696667 0.23526667 -0.08170000 5.650070e-01 7.068732e-12 FALSE  
ENST00000427658 ENSG00000223959 HEK293_OSMI2_2hA HEK293_TMG_2hB AFG3L1P transcribed_unitary_pseudogene retained_intron 18.46252 15.70372 19.46768 0.3452278 0.7332785 0.3097972 1.1514531 0.4977150 1.6640445 0.04965267 0.01489254 1.72124718 0.05910833 0.03170000 0.08576667 0.05406667 5.783778e-05 7.068732e-12 TRUE  
ENST00000436447 ENSG00000223959 HEK293_OSMI2_2hA HEK293_TMG_2hB AFG3L1P transcribed_unitary_pseudogene processed_transcript 18.46252 15.70372 19.46768 0.3452278 0.7332785 0.3097972 0.4421218 1.3111402 0.0000000 0.34658694 0.00000000 -7.04563978 0.02671667 0.08373333 0.00000000 -0.08373333 7.068732e-12 7.068732e-12 TRUE  
ENST00000458301 ENSG00000223959 HEK293_OSMI2_2hA HEK293_TMG_2hB AFG3L1P transcribed_unitary_pseudogene processed_transcript 18.46252 15.70372 19.46768 0.3452278 0.7332785 0.3097972 1.2279713 0.4060486 1.2717927 0.40604864 0.65283451 1.62333882 0.06066667 0.02476667 0.06333333 0.03856667 5.752441e-01 7.068732e-12    
ENST00000690928 ENSG00000223959 HEK293_OSMI2_2hA HEK293_TMG_2hB AFG3L1P transcribed_unitary_pseudogene processed_transcript 18.46252 15.70372 19.46768 0.3452278 0.7332785 0.3097972 1.4574456 1.4226165 1.6324101 0.04842344 0.94422738 0.19716199 0.08425833 0.09060000 0.08043333 -0.01016667 8.246935e-01 7.068732e-12 FALSE  
MSTRG.13292.12 ENSG00000223959 HEK293_OSMI2_2hA HEK293_TMG_2hB AFG3L1P transcribed_unitary_pseudogene   18.46252 15.70372 19.46768 0.3452278 0.7332785 0.3097972 1.5673113 1.0121561 1.6203115 0.39143153 0.38443173 0.67353215 0.08681250 0.06510000 0.08486667 0.01976667 7.898114e-01 7.068732e-12 TRUE  
MSTRG.13292.25 ENSG00000223959 HEK293_OSMI2_2hA HEK293_TMG_2hB AFG3L1P transcribed_unitary_pseudogene   18.46252 15.70372 19.46768 0.3452278 0.7332785 0.3097972 1.3062642 1.3389714 0.9686031 0.21475810 0.18183562 -0.46306405 0.07608333 0.08476667 0.05026667 -0.03450000 2.599261e-01 7.068732e-12 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000223959 E001 0.1472490 0.0425907890 5.195665e-01   16 89969087 89969191 105 + 0.119 0.000 -9.783
ENSG00000223959 E002 0.1451727 0.0450328456 5.185326e-01   16 89969192 89969275 84 + 0.119 0.000 -12.314
ENSG00000223959 E003 0.4482035 0.0339086745 9.596396e-02 1.843317e-01 16 89969276 89969478 203 + 0.288 0.000 -13.934
ENSG00000223959 E004 0.4513240 0.2031696858 6.460075e-01 7.580502e-01 16 89969479 89969570 92 + 0.212 0.125 -0.918
ENSG00000223959 E005 0.1482932 0.0414751861 4.608089e-01   16 89969571 89969623 53 + 0.000 0.126 11.608
ENSG00000223959 E006 0.4513240 0.2031696858 6.460075e-01 7.580502e-01 16 89969624 89969755 132 + 0.212 0.125 -0.918
ENSG00000223959 E007 0.3030308 0.3889524781 3.169345e-01   16 89969756 89969779 24 + 0.212 0.000 -12.297
ENSG00000223959 E008 0.0000000       16 89969780 89969824 45 +      
ENSG00000223959 E009 1.9209041 0.2205853212 4.676783e-01 6.071713e-01 16 89969825 89972580 2756 + 0.505 0.384 -0.630
ENSG00000223959 E010 0.1472490 0.0425907890 5.195665e-01   16 89972581 89972581 1 + 0.119 0.000 -12.334
ENSG00000223959 E011 0.1472490 0.0425907890 5.195665e-01   16 89972582 89972585 4 + 0.119 0.000 -12.334
ENSG00000223959 E012 0.2987644 0.0274424043 2.188713e-01   16 89972586 89972588 3 + 0.212 0.000 -13.436
ENSG00000223959 E013 0.2987644 0.0274424043 2.188713e-01   16 89972589 89972589 1 + 0.212 0.000 -13.436
ENSG00000223959 E014 0.8877725 0.0138254051 4.567677e-01 5.971353e-01 16 89972590 89972592 3 + 0.353 0.224 -0.899
ENSG00000223959 E015 0.8877725 0.0138254051 4.567677e-01 5.971353e-01 16 89972593 89972593 1 + 0.353 0.224 -0.899
ENSG00000223959 E016 0.8877725 0.0138254051 4.567677e-01 5.971353e-01 16 89972594 89972595 2 + 0.353 0.224 -0.899
ENSG00000223959 E017 4.9339219 0.0034353109 2.779842e-01 4.176194e-01 16 89972596 89972607 12 + 0.678 0.828 0.607
ENSG00000223959 E018 9.3492595 0.0029114814 1.567564e-01 2.707705e-01 16 89972608 89972615 8 + 0.915 1.072 0.581
ENSG00000223959 E019 9.6761366 0.0020834026 1.594514e-01 2.743948e-01 16 89972616 89972616 1 + 0.931 1.084 0.563
ENSG00000223959 E020 16.5415664 0.0015217802 5.026458e-01 6.386896e-01 16 89972617 89972630 14 + 1.262 1.209 -0.185
ENSG00000223959 E021 19.1130275 0.0014727384 7.599115e-01 8.441545e-01 16 89972631 89972647 17 + 1.304 1.284 -0.071
ENSG00000223959 E022 44.2424037 0.0005514131 4.575861e-01 5.979041e-01 16 89972648 89972765 118 + 1.631 1.674 0.146
ENSG00000223959 E023 4.5874941 0.0113914473 6.994717e-01 7.991954e-01 16 89977605 89977638 34 + 0.780 0.730 -0.200
ENSG00000223959 E024 26.6719945 0.0044972994 3.147161e-01 4.574529e-01 16 89977639 89977677 39 + 1.401 1.477 0.261
ENSG00000223959 E025 33.9251202 0.0069578216 4.593498e-01 5.995305e-01 16 89977678 89977693 16 + 1.515 1.568 0.182
ENSG00000223959 E026 37.5338725 0.0006422736 3.012330e-02 7.220560e-02 16 89977694 89977714 21 + 1.511 1.638 0.436
ENSG00000223959 E027 67.8192877 0.0004417443 4.760636e-02 1.049207e-01 16 89977715 89977802 88 + 1.790 1.878 0.298
ENSG00000223959 E028 17.8722650 0.0010005827 5.627125e-03 1.762369e-02 16 89977803 89978517 715 + 1.379 1.161 -0.765
ENSG00000223959 E029 61.1263486 0.0034563896 8.757546e-03 2.567855e-02 16 89978810 89978878 69 + 1.712 1.854 0.479
ENSG00000223959 E030 8.1529512 0.0020997246 6.349980e-01 7.493737e-01 16 89979302 89979714 413 + 0.991 0.942 -0.181
ENSG00000223959 E031 17.6283103 0.0018389990 9.059369e-01 9.441937e-01 16 89979715 89980241 527 + 1.269 1.283 0.049
ENSG00000223959 E032 48.1349582 0.0031387317 6.086438e-02 1.280919e-01 16 89980242 89980244 3 + 1.628 1.738 0.373
ENSG00000223959 E033 85.1970843 0.0028146997 2.181140e-02 5.528269e-02 16 89980245 89980336 92 + 1.874 1.980 0.358
ENSG00000223959 E034 85.6433024 0.0048760782 1.127647e-01 2.095824e-01 16 89981773 89981918 146 + 1.890 1.972 0.275
ENSG00000223959 E035 34.6001208 0.0179884606 1.242530e-01 2.260530e-01 16 89981919 89981923 5 + 1.472 1.604 0.453
ENSG00000223959 E036 63.2762084 0.0035005800 3.111003e-02 7.411877e-02 16 89984531 89984599 69 + 1.738 1.852 0.385
ENSG00000223959 E037 28.1898355 0.0007338316 2.468539e-01 3.822600e-01 16 89984600 89984606 7 + 1.417 1.496 0.273
ENSG00000223959 E038 26.6646573 0.0007993645 3.945333e-01 5.383575e-01 16 89984607 89984617 11 + 1.406 1.467 0.210
ENSG00000223959 E039 19.7838862 0.0011094350 6.396430e-01 7.529953e-01 16 89984618 89984622 5 + 1.337 1.306 -0.109
ENSG00000223959 E040 24.4093821 0.0091595818 7.127212e-01 8.093636e-01 16 89984623 89984648 26 + 1.422 1.396 -0.091
ENSG00000223959 E041 13.0625781 0.0298652092 4.605307e-01 6.005504e-01 16 89984649 89984656 8 + 1.197 1.114 -0.297
ENSG00000223959 E042 15.2595489 0.0012557749 1.534122e-02 4.126166e-02 16 89984657 89984703 47 + 1.311 1.107 -0.722
ENSG00000223959 E043 20.4313658 0.0432139163 2.517739e-02 6.223863e-02 16 89985446 89985570 125 + 1.458 1.183 -0.962
ENSG00000223959 E044 22.6440424 0.0008640706 7.164955e-04 2.957962e-03 16 89987138 89987176 39 + 1.485 1.244 -0.837
ENSG00000223959 E045 6.8586706 0.0812510195 2.551350e-01 3.919633e-01 16 89988496 89988509 14 + 1.004 0.778 -0.864
ENSG00000223959 E046 16.4959929 0.0229627082 8.567207e-02 1.684674e-01 16 89988510 89988629 120 + 1.337 1.148 -0.668
ENSG00000223959 E047 13.9185419 0.0043225925 1.409088e-02 3.843018e-02 16 89988630 89988681 52 + 1.284 1.058 -0.803
ENSG00000223959 E048 22.7723334 0.0012183941 1.971980e-01 3.227271e-01 16 89988682 89988851 170 + 1.422 1.334 -0.306
ENSG00000223959 E049 50.3664796 0.0005472491 3.824972e-01 5.266901e-01 16 89988852 89988951 100 + 1.725 1.686 -0.132
ENSG00000223959 E050 11.5294014 0.0015378038 7.265431e-04 2.994353e-03 16 89990332 89990865 534 + 1.239 0.908 -1.205
ENSG00000223959 E051 62.1618190 0.0054972687 2.961859e-01 4.373906e-01 16 89990866 89991003 138 + 1.822 1.767 -0.186
ENSG00000223959 E052 4.2457426 0.0075473045 2.488022e-01 3.845293e-01 16 89991229 89991383 155 + 0.802 0.640 -0.664
ENSG00000223959 E053 49.2095116 0.0036048278 7.828407e-01 8.605646e-01 16 89992721 89992828 108 + 1.699 1.688 -0.036
ENSG00000223959 E054 33.3026503 0.0006411717 7.442243e-01 8.326211e-01 16 89993768 89993785 18 + 1.539 1.524 -0.053
ENSG00000223959 E055 35.2953491 0.0037389008 5.023165e-01 6.383779e-01 16 89993786 89993805 20 + 1.577 1.537 -0.136
ENSG00000223959 E056 51.8900023 0.0040347014 9.536616e-01 9.749782e-01 16 89993806 89993893 88 + 1.717 1.720 0.007
ENSG00000223959 E057 16.0116122 0.0010985734 2.306913e-01 3.632809e-01 16 89994693 89994758 66 + 1.171 1.276 0.371
ENSG00000223959 E058 251.1810126 0.0025778923 2.641798e-09 3.623521e-08 16 89994759 89995816 1058 + 2.483 2.310 -0.574
ENSG00000223959 E059 121.8628620 0.0090660424 2.807318e-01 4.206049e-01 16 89995817 89996043 227 + 2.112 2.067 -0.151
ENSG00000223959 E060 213.8505391 0.0092397841 1.974578e-04 9.529676e-04 16 89996044 89996626 583 + 2.219 2.412 0.645
ENSG00000223959 E061 0.4772466 0.0208674305 5.319130e-01 6.643094e-01 16 89996783 89996892 110 + 0.119 0.224 1.102
ENSG00000223959 E062 0.4386386 0.2438704251 6.496865e-01 7.608671e-01 16 89998606 89999195 590 + 0.211 0.125 -0.913
ENSG00000223959 E063 0.0000000       16 89999196 89999311 116 +      
ENSG00000223959 E064 1.2617773 0.0113843742 9.365636e-01 9.640987e-01 16 89999312 89999823 512 + 0.353 0.371 0.101
ENSG00000223959 E065 1.6282815 0.1337102618 9.107278e-01 9.472743e-01 16 89999824 90000024 201 + 0.410 0.428 0.098
ENSG00000223959 E066 1.9981242 0.0080747827 1.337817e-02 3.679734e-02 16 90000103 90000297 195 + 0.649 0.224 -2.356
ENSG00000223959 E067 2.2936795 0.0640611546 5.021537e-02 1.095367e-01 16 90000449 90002161 1713 + 0.679 0.303 -1.901