ENSG00000223891

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435163 ENSG00000223891 HEK293_OSMI2_2hA HEK293_TMG_2hB OSER1-DT lncRNA lncRNA 3.118306 4.598747 1.569165 0.1262618 0.04038218 -1.545213 0.29833214 0.5678549 0.06530399 0.05016029 0.06530399 -2.93990899 0.08808333 0.12420000 0.04206667 -0.08213333 0.3008999438 0.0006556809   FALSE
ENST00000439943 ENSG00000223891 HEK293_OSMI2_2hA HEK293_TMG_2hB OSER1-DT lncRNA lncRNA 3.118306 4.598747 1.569165 0.1262618 0.04038218 -1.545213 0.24225939 0.0834335 0.10982120 0.08343350 0.05539723 0.35887139 0.07061667 0.01913333 0.07170000 0.05256667 0.4908887524 0.0006556809   FALSE
ENST00000442383 ENSG00000223891 HEK293_OSMI2_2hA HEK293_TMG_2hB OSER1-DT lncRNA lncRNA 3.118306 4.598747 1.569165 0.1262618 0.04038218 -1.545213 1.00476884 1.5046401 0.67094781 0.17622480 0.37030379 -1.15335889 0.30215833 0.32976667 0.41660000 0.08683333 1.0000000000 0.0006556809   FALSE
ENST00000655968 ENSG00000223891 HEK293_OSMI2_2hA HEK293_TMG_2hB OSER1-DT lncRNA lncRNA 3.118306 4.598747 1.569165 0.1262618 0.04038218 -1.545213 0.23144873 0.4872588 0.00000000 0.13900177 0.00000000 -5.63592511 0.06400833 0.10556667 0.00000000 -0.10556667 0.0006556809 0.0006556809   FALSE
ENST00000660003 ENSG00000223891 HEK293_OSMI2_2hA HEK293_TMG_2hB OSER1-DT lncRNA lncRNA 3.118306 4.598747 1.569165 0.1262618 0.04038218 -1.545213 0.10571213 0.1493250 0.15801845 0.09423023 0.02829314 0.07664684 0.03960833 0.03186667 0.10033333 0.06846667 0.3464302339 0.0006556809   FALSE
ENST00000664132 ENSG00000223891 HEK293_OSMI2_2hA HEK293_TMG_2hB OSER1-DT lncRNA lncRNA 3.118306 4.598747 1.569165 0.1262618 0.04038218 -1.545213 0.07444256 0.0000000 0.23667559 0.00000000 0.23667559 4.62454303 0.04185000 0.00000000 0.15683333 0.15683333 0.6898658418 0.0006556809   FALSE
ENST00000671199 ENSG00000223891 HEK293_OSMI2_2hA HEK293_TMG_2hB OSER1-DT lncRNA lncRNA 3.118306 4.598747 1.569165 0.1262618 0.04038218 -1.545213 0.89983242 1.5293730 0.23884829 0.39364515 0.06539043 -2.62900447 0.31137500 0.32853333 0.15443333 -0.17410000 0.2601152128 0.0006556809   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000223891 E001 0.0000000       20 44210907 44210942 36 +      
ENSG00000223891 E002 0.3332198 0.028881894 0.44560803   20 44210943 44210959 17 + 0.184 0.079 -1.399
ENSG00000223891 E003 0.4783925 0.020735496 0.14386846 0.25327753 20 44210960 44210991 32 + 0.313 0.079 -2.399
ENSG00000223891 E004 0.6235652 0.018660307 0.04333051 0.09716851 20 44210992 44210994 3 + 0.413 0.079 -2.984
ENSG00000223891 E005 3.5292783 0.037190291 0.02100524 0.05360083 20 44210995 44211011 17 + 0.833 0.480 -1.526
ENSG00000223891 E006 4.1559640 0.030180782 0.01247600 0.03467840 20 44211012 44211019 8 + 0.896 0.534 -1.508
ENSG00000223891 E007 5.4802947 0.014273458 0.09032993 0.17564132 20 44211020 44211026 7 + 0.896 0.683 -0.846
ENSG00000223891 E008 6.1016673 0.015988314 0.32034090 0.46344472 20 44211027 44211036 10 + 0.866 0.751 -0.452
ENSG00000223891 E009 7.6192434 0.002410563 0.59972668 0.72107542 20 44211037 44211077 41 + 0.896 0.858 -0.145
ENSG00000223891 E010 0.5212538 0.020420978 0.76764237 0.84983987 20 44211078 44211081 4 + 0.184 0.146 -0.400
ENSG00000223891 E011 17.8995841 0.001297201 0.26154546 0.39919598 20 44211082 44211356 275 + 1.253 1.188 -0.229
ENSG00000223891 E012 1.2597141 0.036549290 0.16359787 0.27981732 20 44212834 44214887 2054 + 0.494 0.255 -1.405
ENSG00000223891 E013 4.3447369 0.004059470 0.73170280 0.82330907 20 44214888 44214897 10 + 0.620 0.699 0.336
ENSG00000223891 E014 8.4326151 0.002658513 0.74296889 0.83175197 20 44214898 44215003 106 + 0.866 0.935 0.262
ENSG00000223891 E015 8.7314668 0.002174472 0.81432830 0.88235276 20 44217367 44217682 316 + 0.924 0.925 0.003
ENSG00000223891 E016 1.5489982 0.065851560 0.36622399 0.51056779 20 44217683 44218751 1069 + 0.184 0.384 1.428
ENSG00000223891 E017 10.1696182 0.019760554 0.08964942 0.17458689 20 44219789 44223718 3930 + 0.760 1.028 1.024
ENSG00000223891 E018 0.4481018 0.095262086 0.75622180 0.84134832 20 44223719 44223872 154 + 0.184 0.145 -0.416
ENSG00000223891 E019 103.6075959 0.013636942 0.02525041 0.06238736 20 44224821 44226027 1207 + 1.856 1.978 0.411