ENSG00000223745

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000411670 ENSG00000223745 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.24737 2.358355 4.60349 0.2015545 0.6275952 0.9619733 0.02470255 0.11463626 0.00000000 0.08662178 0.00000000 -3.63965198 0.01066667 0.05513333 0.00000000 -0.05513333 1.384061e-01 2.828951e-05   FALSE
ENST00000413606 ENSG00000223745 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.24737 2.358355 4.60349 0.2015545 0.6275952 0.9619733 0.66967966 0.42323508 0.81606156 0.02463502 0.14843887 0.93109924 0.21358750 0.18036667 0.18036667 0.00000000 9.984439e-01 2.828951e-05 TRUE FALSE
ENST00000429859 ENSG00000223745 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.24737 2.358355 4.60349 0.2015545 0.6275952 0.9619733 0.02817697 0.13135451 0.00000000 0.13135451 0.00000000 -3.82124605 0.01139583 0.06613333 0.00000000 -0.06613333 6.980334e-01 2.828951e-05   FALSE
ENST00000445076 ENSG00000223745 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.24737 2.358355 4.60349 0.2015545 0.6275952 0.9619733 0.23629839 0.09839624 0.15124166 0.05391156 0.15124166 0.57290983 0.07404167 0.04406667 0.02703333 -0.01703333 7.005247e-01 2.828951e-05 FALSE TRUE
ENST00000446528 ENSG00000223745 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.24737 2.358355 4.60349 0.2015545 0.6275952 0.9619733 0.10133138 0.00000000 0.41112153 0.00000000 0.41112153 5.39616474 0.02807083 0.00000000 0.07350000 0.07350000 9.059956e-01 2.828951e-05   FALSE
ENST00000447577 ENSG00000223745 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.24737 2.358355 4.60349 0.2015545 0.6275952 0.9619733 0.24621461 0.37775203 0.35516874 0.12067536 0.18876420 -0.08657105 0.08880000 0.15456667 0.08580000 -0.06876667 6.777916e-01 2.828951e-05   FALSE
ENST00000602488 ENSG00000223745 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.24737 2.358355 4.60349 0.2015545 0.6275952 0.9619733 0.15401654 0.08307478 0.41751107 0.08307478 0.21867977 2.19949953 0.04632500 0.03446667 0.10746667 0.07300000 6.967983e-01 2.828951e-05   FALSE
ENST00000653362 ENSG00000223745 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.24737 2.358355 4.60349 0.2015545 0.6275952 0.9619733 0.18974246 0.09291145 0.35352110 0.03325746 0.08188742 1.82063567 0.05744583 0.04183333 0.07720000 0.03536667 4.124907e-01 2.828951e-05 TRUE FALSE
ENST00000659026 ENSG00000223745 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.24737 2.358355 4.60349 0.2015545 0.6275952 0.9619733 0.07274487 0.16226541 0.00000000 0.02198848 0.00000000 -4.10656118 0.02591667 0.07140000 0.00000000 -0.07140000 2.828951e-05 2.828951e-05 TRUE FALSE
ENST00000668257 ENSG00000223745 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.24737 2.358355 4.60349 0.2015545 0.6275952 0.9619733 0.11708713 0.26407751 0.09152352 0.16517505 0.09152352 -1.43276991 0.03950833 0.10646667 0.01916667 -0.08730000 4.713474e-01 2.828951e-05 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000223745 E001 5.5219150 0.003065967 0.432433138 0.57488727 1 93262186 93262361 176 - 0.779 0.871 0.360
ENSG00000223745 E002 1.3725078 0.010794040 0.716543599 0.81217563 1 93264638 93264639 2 - 0.412 0.343 -0.393
ENSG00000223745 E003 1.3725078 0.010794040 0.716543599 0.81217563 1 93264640 93264644 5 - 0.412 0.343 -0.393
ENSG00000223745 E004 1.4026967 0.009626151 0.752423461 0.83860480 1 93264645 93264646 2 - 0.365 0.416 0.286
ENSG00000223745 E005 1.4026967 0.009626151 0.752423461 0.83860480 1 93264647 93264649 3 - 0.365 0.416 0.286
ENSG00000223745 E006 1.2909352 0.129700704 0.627089264 0.74293309 1 93264650 93264650 1 - 0.313 0.416 0.603
ENSG00000223745 E007 1.5876233 0.035712183 0.968418251 0.98426969 1 93264651 93264668 18 - 0.412 0.416 0.022
ENSG00000223745 E008 1.5135263 0.108506351 0.768029785 0.85011211 1 93264669 93264671 3 - 0.365 0.419 0.300
ENSG00000223745 E009 1.5135263 0.108506351 0.768029785 0.85011211 1 93264672 93264675 4 - 0.365 0.419 0.300
ENSG00000223745 E010 1.5135263 0.108506351 0.768029785 0.85011211 1 93264676 93264676 1 - 0.365 0.419 0.300
ENSG00000223745 E011 3.0278828 0.005409633 0.241956295 0.37650122 1 93264677 93264704 28 - 0.528 0.700 0.759
ENSG00000223745 E012 3.3590263 0.005339400 0.226453836 0.35816497 1 93264705 93264740 36 - 0.561 0.734 0.745
ENSG00000223745 E013 3.1836646 0.022603582 0.368324066 0.51274848 1 93264741 93264747 7 - 0.561 0.699 0.603
ENSG00000223745 E014 4.0974734 0.004493429 0.268994393 0.40745979 1 93264748 93264772 25 - 0.646 0.794 0.607
ENSG00000223745 E015 0.4847352 0.240880141 0.900260524 0.94035726 1 93269683 93269758 76 - 0.184 0.147 -0.392
ENSG00000223745 E016 0.0000000       1 93273474 93273583 110 -      
ENSG00000223745 E017 0.2934659 0.028317331 0.745387102   1 93290565 93290686 122 - 0.102 0.146 0.607
ENSG00000223745 E018 0.5546650 0.020911273 0.338758239 0.48264432 1 93305111 93305387 277 - 0.102 0.257 1.611
ENSG00000223745 E019 6.8266910 0.003924726 0.020051239 0.05159453 1 93305388 93305470 83 - 0.759 1.027 1.022
ENSG00000223745 E020 0.0000000       1 93309540 93309634 95 -      
ENSG00000223745 E021 1.4820912 0.141989439 0.721963873 0.81618046 1 93309715 93309752 38 - 0.365 0.469 0.560
ENSG00000223745 E022 1.2188142 0.012125564 0.192504434 0.31690206 1 93309753 93309770 18 - 0.253 0.478 1.342
ENSG00000223745 E023 1.3639869 0.010968530 0.330842295 0.47440946 1 93309771 93309790 20 - 0.313 0.478 0.927
ENSG00000223745 E024 0.0000000       1 93310128 93310200 73 -      
ENSG00000223745 E025 4.1655304 0.034746224 0.998860123 1.00000000 1 93310201 93311168 968 - 0.717 0.701 -0.068
ENSG00000223745 E026 1.6327634 0.147456146 0.686505561 0.78902004 1 93311169 93311279 111 - 0.454 0.346 -0.599
ENSG00000223745 E027 1.1209728 0.199805308 0.693502151 0.79452956 1 93311280 93311328 49 - 0.366 0.257 -0.715
ENSG00000223745 E028 2.2958685 0.007490645 0.643451055 0.75600102 1 93311329 93311484 156 - 0.561 0.478 -0.393
ENSG00000223745 E029 1.0298247 0.012390007 0.153752111 0.26676811 1 93311485 93311489 5 - 0.412 0.147 -1.977
ENSG00000223745 E030 4.1684368 0.004327363 0.582085386 0.70650631 1 93311490 93311608 119 - 0.695 0.765 0.285
ENSG00000223745 E031 2.5380525 0.006210121 0.899316010 0.93976089 1 93315149 93315173 25 - 0.561 0.533 -0.128
ENSG00000223745 E032 2.4198465 0.006836566 0.270334697 0.40896029 1 93315174 93315215 42 - 0.454 0.625 0.801
ENSG00000223745 E033 2.5326402 0.006402306 0.709300893 0.80672711 1 93315216 93315266 51 - 0.528 0.581 0.246
ENSG00000223745 E034 1.1394067 0.011413180 0.342125214 0.48612162 1 93315267 93315269 3 - 0.253 0.416 1.023
ENSG00000223745 E035 0.9921577 0.012762528 0.177763106 0.29832210 1 93318168 93318228 61 - 0.184 0.416 1.608
ENSG00000223745 E036 6.4295809 0.105685361 0.226773267 0.35853250 1 93324635 93324652 18 - 0.796 0.952 0.600
ENSG00000223745 E037 8.4590519 0.051765078 0.387376350 0.53151078 1 93324653 93324705 53 - 0.936 1.024 0.329
ENSG00000223745 E038 6.9258451 0.007489249 0.590703234 0.71353760 1 93324706 93324721 16 - 0.880 0.935 0.210
ENSG00000223745 E039 6.4078135 0.004694147 0.996218492 1.00000000 1 93324722 93324729 8 - 0.880 0.871 -0.037
ENSG00000223745 E040 9.6789881 0.001912482 0.964001580 0.98130219 1 93325769 93325818 50 - 1.031 1.027 -0.016
ENSG00000223745 E041 10.8799186 0.002580983 0.543815043 0.67436967 1 93325819 93325895 77 - 1.052 1.102 0.181
ENSG00000223745 E042 1.2459714 0.067740247 0.960134565 0.97890892 1 93326602 93326662 61 - 0.365 0.343 -0.130
ENSG00000223745 E043 5.6240864 0.048682763 0.812663294 0.88119789 1 93333343 93333398 56 - 0.814 0.843 0.111
ENSG00000223745 E044 0.0000000       1 93336975 93337062 88 -      
ENSG00000223745 E045 0.0000000       1 93337063 93337174 112 -      
ENSG00000223745 E046 1.3221327 0.366586508 0.218950424 0.34913642 1 93337175 93337376 202 - 0.491 0.144 -2.413
ENSG00000223745 E047 6.1851985 0.003076887 0.230971782 0.36363789 1 93337377 93337512 136 - 0.923 0.765 -0.614
ENSG00000223745 E048 9.8549331 0.005100784 0.178811683 0.29965315 1 93337513 93338130 618 - 1.091 0.937 -0.568
ENSG00000223745 E049 2.3303118 0.006451638 0.314004621 0.45667022 1 93338131 93338229 99 - 0.591 0.416 -0.851
ENSG00000223745 E050 2.5078635 0.006096810 0.519495344 0.65358796 1 93338230 93338268 39 - 0.591 0.478 -0.529
ENSG00000223745 E051 4.4671522 0.098633098 0.121745873 0.22241886 1 93338269 93338373 105 - 0.849 0.532 -1.331
ENSG00000223745 E052 12.1494838 0.050701677 0.006228941 0.01921631 1 93338374 93338914 541 - 1.252 0.847 -1.484
ENSG00000223745 E053 3.4676197 0.055144561 0.015410945 0.04142509 1 93338915 93338928 14 - 0.797 0.343 -2.131
ENSG00000223745 E054 8.2819488 0.006564752 0.003998290 0.01313767 1 93338929 93339155 227 - 1.091 0.734 -1.359
ENSG00000223745 E055 7.1172929 0.002462820 0.155761988 0.26944594 1 93339156 93339274 119 - 0.975 0.794 -0.690
ENSG00000223745 E056 0.7406253 0.015475718 0.053259418 0.11494591 1 93339275 93339356 82 - 0.365 0.000 -10.755
ENSG00000223745 E057 28.8272572 0.000776678 0.229548773 0.36189678 1 93339357 93339536 180 - 1.445 1.510 0.221
ENSG00000223745 E058 6.6137415 0.003083547 0.352401027 0.49666208 1 93339649 93339679 31 - 0.832 0.936 0.397
ENSG00000223745 E059 10.6808099 0.001940808 0.572474969 0.69859269 1 93340458 93340510 53 - 1.042 1.088 0.169
ENSG00000223745 E060 3.1303820 0.007417177 0.780126543 0.85868039 1 93345540 93345590 51 - 0.591 0.625 0.151
ENSG00000223745 E061 2.8077713 0.067462104 0.799907462 0.87240905 1 93345591 93345645 55 - 0.561 0.584 0.104
ENSG00000223745 E062 2.7627068 0.006388711 0.757358742 0.84221770 1 93345646 93345723 78 - 0.591 0.533 -0.264
ENSG00000223745 E063 14.2650447 0.006751939 0.611792949 0.73085771 1 93345724 93346025 302 - 1.167 1.201 0.119