ENSG00000221978

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000400809 ENSG00000221978 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL2 protein_coding protein_coding 75.00439 64.25913 70.59 4.700967 0.8794985 0.1355422 6.684141 8.524366 3.749088 1.0302408 0.1160412 -1.1829013 0.09137083 0.13176667 0.0531000 -0.07866667 1.880510e-14 1.88051e-14 FALSE  
ENST00000408918 ENSG00000221978 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL2 protein_coding protein_coding 75.00439 64.25913 70.59 4.700967 0.8794985 0.1355422 17.280766 13.535103 19.740976 0.4499222 0.2948073 0.5441526 0.23290417 0.21380000 0.2796667 0.06586667 1.545835e-01 1.88051e-14 FALSE  
ENST00000418865 ENSG00000221978 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL2 protein_coding retained_intron 75.00439 64.25913 70.59 4.700967 0.8794985 0.1355422 19.999220 13.934809 19.243895 2.1173909 0.2237014 0.4654221 0.26028333 0.21440000 0.2727333 0.05833333 1.597586e-01 1.88051e-14 FALSE  
ENST00000473872 ENSG00000221978 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL2 protein_coding retained_intron 75.00439 64.25913 70.59 4.700967 0.8794985 0.1355422 8.028571 2.687754 8.799797 0.3660879 0.0809823 1.7073500 0.10772500 0.04266667 0.1247333 0.08206667 5.400021e-06 1.88051e-14 FALSE  
ENST00000481223 ENSG00000221978 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL2 protein_coding nonsense_mediated_decay 75.00439 64.25913 70.59 4.700967 0.8794985 0.1355422 4.573969 6.918313 1.584330 1.1324018 0.6931643 -2.1195535 0.06078333 0.10640000 0.0222000 -0.08420000 8.708344e-04 1.88051e-14 FALSE  
ENST00000482621 ENSG00000221978 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL2 protein_coding nonsense_mediated_decay 75.00439 64.25913 70.59 4.700967 0.8794985 0.1355422 3.481043 6.367841 1.233063 0.9502851 0.4032291 -2.3591687 0.04858333 0.09903333 0.0176000 -0.08143333 2.343085e-04 1.88051e-14 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000221978 E001 81.297241 0.0023100113 2.521662e-09 3.470803e-08 1 1385711 1386278 568 - 1.710 1.984 0.927
ENSG00000221978 E002 54.724518 0.0014033684 1.669767e-11 3.353110e-10 1 1386279 1386481 203 - 1.465 1.827 1.232
ENSG00000221978 E003 23.112405 0.0008157703 2.335759e-06 1.790784e-05 1 1386482 1386494 13 - 1.107 1.468 1.267
ENSG00000221978 E004 20.310053 0.0009336306 2.903967e-04 1.340777e-03 1 1386495 1386496 2 - 1.120 1.402 0.991
ENSG00000221978 E005 19.839149 0.0009551984 2.998855e-04 1.379076e-03 1 1386497 1386498 2 - 1.107 1.392 1.003
ENSG00000221978 E006 18.727945 0.0009901811 1.741097e-03 6.411867e-03 1 1386499 1386501 3 - 1.107 1.356 0.880
ENSG00000221978 E007 132.974971 0.0004821126 9.118397e-10 1.362130e-08 1 1386502 1386707 206 - 1.978 2.170 0.644
ENSG00000221978 E008 67.520016 0.0003617047 7.128927e-06 4.898813e-05 1 1386708 1386712 5 - 1.693 1.882 0.637
ENSG00000221978 E009 589.409614 0.0002338442 3.630032e-33 7.726951e-31 1 1386713 1387121 409 - 2.630 2.812 0.609
ENSG00000221978 E010 368.097462 0.0001532513 1.023831e-21 7.881417e-20 1 1387122 1387231 110 - 2.431 2.606 0.582
ENSG00000221978 E011 193.044325 0.0001914478 8.761094e-07 7.364614e-06 1 1387232 1387234 3 - 2.195 2.311 0.387
ENSG00000221978 E012 635.707364 0.0001595157 1.072464e-12 2.616213e-11 1 1387235 1387542 308 - 2.728 2.820 0.304
ENSG00000221978 E013 237.668822 0.0001630117 1.514785e-04 7.536609e-04 1 1387543 1387582 40 - 2.313 2.387 0.248
ENSG00000221978 E014 322.321816 0.0001707680 1.230975e-03 4.745524e-03 1 1387777 1387869 93 - 2.460 2.511 0.169
ENSG00000221978 E015 297.812376 0.0002540160 5.118345e-02 1.112615e-01 1 1387954 1388022 69 - 2.441 2.467 0.089
ENSG00000221978 E016 260.583701 0.0018703899 2.216029e-01 3.523191e-01 1 1388023 1388065 43 - 2.384 2.409 0.082
ENSG00000221978 E017 21.205866 0.0042064257 9.683929e-01 9.842545e-01 1 1388066 1388491 426 - 1.341 1.328 -0.044
ENSG00000221978 E018 4.273738 0.0037964547 6.309258e-01 7.460459e-01 1 1388492 1388510 19 - 0.682 0.736 0.226
ENSG00000221978 E019 5.061603 0.0031626628 7.269174e-01 8.198187e-01 1 1388511 1388625 115 - 0.746 0.779 0.134
ENSG00000221978 E020 9.645393 0.0020099231 5.896532e-01 7.126918e-01 1 1388626 1388743 118 - 0.989 1.031 0.154
ENSG00000221978 E021 10.553228 0.0032388184 3.466735e-01 4.907953e-01 1 1388950 1389047 98 - 1.120 1.008 -0.408
ENSG00000221978 E022 10.095473 0.0256443863 8.195684e-01 8.860729e-01 1 1389346 1389473 128 - 1.067 1.018 -0.178
ENSG00000221978 E023 387.160101 0.0015980182 3.224587e-01 4.657572e-01 1 1390230 1390371 142 - 2.564 2.578 0.046
ENSG00000221978 E024 341.300438 0.0024020134 6.474273e-01 7.590909e-01 1 1390459 1390563 105 - 2.518 2.521 0.010
ENSG00000221978 E025 304.695235 0.0022743481 5.959409e-01 7.179552e-01 1 1390766 1390865 100 - 2.489 2.460 -0.096
ENSG00000221978 E026 356.180001 0.0016967374 1.485515e-04 7.406735e-04 1 1390866 1391152 287 - 2.603 2.489 -0.380
ENSG00000221978 E027 223.896454 0.0008380592 6.219405e-04 2.613334e-03 1 1391153 1391296 144 - 2.397 2.288 -0.364
ENSG00000221978 E028 94.405091 0.0003446251 9.339487e-03 2.713116e-02 1 1391297 1391306 10 - 2.027 1.914 -0.380
ENSG00000221978 E029 280.937347 0.0038555302 3.949173e-03 1.300038e-02 1 1391307 1391553 247 - 2.501 2.386 -0.383
ENSG00000221978 E030 104.533270 0.0026915120 8.597385e-06 5.800181e-05 1 1391554 1391575 22 - 2.120 1.917 -0.682
ENSG00000221978 E031 382.269434 0.0008711509 5.979406e-30 1.004238e-27 1 1391576 1392287 712 - 2.714 2.443 -0.903
ENSG00000221978 E032 334.411768 0.0019518572 7.446277e-10 1.131618e-08 1 1392288 1392678 391 - 2.620 2.428 -0.640
ENSG00000221978 E033 226.248587 0.0018052464 1.606435e-02 4.287908e-02 1 1392679 1392789 111 - 2.397 2.305 -0.306
ENSG00000221978 E034 123.591484 0.0002970574 2.244818e-01 3.557945e-01 1 1392790 1392803 14 - 2.115 2.059 -0.189
ENSG00000221978 E035 54.893737 0.0005131643 3.758434e-26 4.532298e-24 1 1393080 1393395 316 - 1.985 1.451 -1.808
ENSG00000221978 E036 235.956090 0.0010927517 1.715636e-01 2.902424e-01 1 1393396 1393443 48 - 2.394 2.339 -0.184
ENSG00000221978 E037 172.652330 0.0071369951 3.576654e-01 5.020832e-01 1 1393444 1393460 17 - 2.265 2.202 -0.211
ENSG00000221978 E038 17.880778 0.0009896686 6.367476e-10 9.801733e-09 1 1395185 1395393 209 - 1.513 0.996 -1.827
ENSG00000221978 E039 202.673043 0.0034351389 9.091413e-01 9.462995e-01 1 1395394 1395436 43 - 2.309 2.287 -0.073
ENSG00000221978 E040 261.519425 0.0042452382 9.762516e-02 1.868633e-01 1 1395437 1395514 78 - 2.454 2.373 -0.271
ENSG00000221978 E041 1.980252 0.0199879885 1.181788e-01 2.173209e-01 1 1395515 1395537 23 - 0.607 0.326 -1.446
ENSG00000221978 E042 272.252786 0.0013027434 1.102765e-03 4.312294e-03 1 1398233 1398342 110 - 2.485 2.378 -0.356
ENSG00000221978 E043 5.757983 0.0537089175 1.833583e-01 3.054257e-01 1 1398343 1398366 24 - 0.954 0.713 -0.942
ENSG00000221978 E044 213.968977 0.0050959936 7.000767e-02 1.433826e-01 1 1398597 1398671 75 - 2.373 2.278 -0.316
ENSG00000221978 E045 3.191346 0.1049425039 4.591029e-04 2.002940e-03 1 1398672 1398956 285 - 0.916 0.193 -3.699
ENSG00000221978 E046 3.054009 0.0560887562 1.402022e-01 2.483004e-01 1 1398988 1399018 31 - 0.746 0.471 -1.224
ENSG00000221978 E047 252.165509 0.0038632700 7.147013e-02 1.457821e-01 1 1399019 1399335 317 - 2.438 2.353 -0.283