ENSG00000221890

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333039 ENSG00000221890 HEK293_OSMI2_2hA HEK293_TMG_2hB NPTXR protein_coding protein_coding 5.291015 6.320636 4.596665 0.5233003 0.01571249 -0.4586276 4.742750 6.227006 3.539226 0.4723522 0.2458580 -0.8133492 0.8903875 0.986433333 0.7696000 -0.2168333 8.966184e-05 1.095104e-07 FALSE TRUE
MSTRG.22126.3 ENSG00000221890 HEK293_OSMI2_2hA HEK293_TMG_2hB NPTXR protein_coding   5.291015 6.320636 4.596665 0.5233003 0.01571249 -0.4586276 0.523456 0.027252 1.043243 0.0272520 0.2177556 4.8213763 0.1059417 0.004066667 0.2272667 0.2232000 1.095104e-07 1.095104e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000221890 E001 1.402768 0.384508255 3.662187e-01 5.105642e-01 22 38809567 38809742 176 - 0.147 0.430 2.073
ENSG00000221890 E002 87.331627 0.005898125 1.134999e-09 1.665822e-08 22 38818452 38818944 493 - 1.675 2.019 1.161
ENSG00000221890 E003 724.352869 0.002024647 5.263488e-03 1.664834e-02 22 38818945 38822833 3889 - 2.812 2.853 0.136
ENSG00000221890 E004 47.209811 0.007679477 3.155026e-02 7.497996e-02 22 38823083 38823262 180 - 1.736 1.613 -0.420
ENSG00000221890 E005 48.958488 0.004660032 2.125570e-03 7.613305e-03 22 38826500 38826747 248 - 1.770 1.605 -0.561
ENSG00000221890 E006 44.732167 0.006942079 1.075101e-02 3.057029e-02 22 38828287 38828509 223 - 1.724 1.573 -0.511
ENSG00000221890 E007 10.669836 0.025011718 1.445550e-02 3.925787e-02 22 38828510 38828512 3 - 1.201 0.914 -1.049
ENSG00000221890 E008 29.044022 0.015570119 2.142145e-10 3.568928e-09 22 38843235 38844028 794 - 1.720 1.180 -1.865