ENSG00000221838

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359593 ENSG00000221838 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4M1 protein_coding protein_coding 10.96696 17.10069 6.791365 1.425157 0.3585234 -1.331002 0.5547459 0.2687660 0.3092010 0.26876599 0.1738056 0.1954108 0.05272917 0.01393333 0.04526667 0.03133333 0.531012370 0.009696549 FALSE  
ENST00000421755 ENSG00000221838 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4M1 protein_coding protein_coding 10.96696 17.10069 6.791365 1.425157 0.3585234 -1.331002 4.3053428 7.0485826 1.6077897 1.06460520 0.8210326 -2.1253544 0.37824583 0.42023333 0.24430000 -0.17593333 0.706463692 0.009696549 FALSE  
ENST00000422582 ENSG00000221838 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4M1 protein_coding protein_coding 10.96696 17.10069 6.791365 1.425157 0.3585234 -1.331002 0.7991870 1.5710041 0.7098318 0.11271083 0.1163030 -1.1351094 0.07199167 0.09393333 0.10463333 0.01070000 0.902658764 0.009696549 FALSE  
ENST00000438383 ENSG00000221838 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4M1 protein_coding protein_coding 10.96696 17.10069 6.791365 1.425157 0.3585234 -1.331002 0.8479805 1.1928750 0.9391422 0.71963243 0.2724129 -0.3417905 0.07725417 0.06816667 0.13470000 0.06653333 0.652688570 0.009696549 FALSE  
ENST00000463195 ENSG00000221838 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4M1 protein_coding retained_intron 10.96696 17.10069 6.791365 1.425157 0.3585234 -1.331002 0.5195692 0.4752147 0.3085974 0.13352900 0.1818431 -0.6068887 0.05084583 0.02723333 0.04290000 0.01566667 0.996376543 0.009696549 TRUE  
ENST00000489387 ENSG00000221838 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4M1 protein_coding retained_intron 10.96696 17.10069 6.791365 1.425157 0.3585234 -1.331002 0.9701813 1.1594977 0.9898538 0.07680305 0.1840811 -0.2260999 0.09994583 0.06803333 0.14433333 0.07630000 0.009696549 0.009696549    
MSTRG.30327.1 ENSG00000221838 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4M1 protein_coding   10.96696 17.10069 6.791365 1.425157 0.3585234 -1.331002 0.5221558 0.5510242 0.7752483 0.55102419 0.7752483 0.4850859 0.05141667 0.02856667 0.11136667 0.08280000 0.952406373 0.009696549 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000221838 E001 3.1540389 0.1278857258 0.1540215381 0.267142607 7 100100994 100101051 58 + 0.750 0.480 -1.196
ENSG00000221838 E002 3.0989308 0.0051228855 0.1645088211 0.281039530 7 100101472 100101496 25 + 0.703 0.479 -1.009
ENSG00000221838 E003 1.1049513 0.0734186795 0.0813906157 0.161735420 7 100101549 100101556 8 + 0.520 0.190 -2.080
ENSG00000221838 E004 2.7634363 0.1359511396 0.0284808076 0.068975753 7 100101557 100101590 34 + 0.831 0.385 -2.020
ENSG00000221838 E005 5.6032680 0.0144063687 0.0811453212 0.161330902 7 100101591 100101635 45 + 0.931 0.684 -0.973
ENSG00000221838 E006 5.6774642 0.0036551894 0.1431193696 0.252271304 7 100101636 100101642 7 + 0.900 0.701 -0.788
ENSG00000221838 E007 7.7674254 0.0022195437 0.0515175243 0.111850380 7 100101643 100101658 16 + 1.035 0.800 -0.891
ENSG00000221838 E008 9.2263564 0.0232243958 0.7131148717 0.809650502 7 100101659 100101663 5 + 0.959 0.913 -0.174
ENSG00000221838 E009 16.7422312 0.0013216772 0.4830345288 0.621123081 7 100101664 100101707 44 + 1.205 1.140 -0.232
ENSG00000221838 E010 40.6240921 0.0008560635 0.5514436762 0.680902851 7 100101708 100101768 61 + 1.553 1.517 -0.124
ENSG00000221838 E011 31.8925704 0.0009693056 0.7851214237 0.862244486 7 100101769 100101772 4 + 1.403 1.426 0.077
ENSG00000221838 E012 0.2934659 0.0293276146 0.3984097252   7 100101773 100101865 93 + 0.198 0.073 -1.664
ENSG00000221838 E013 0.8919372 0.3434310316 0.5377246052 0.669244556 7 100101866 100101879 14 + 0.334 0.229 -0.744
ENSG00000221838 E014 56.5848948 0.0021141187 0.6720995168 0.778188713 7 100101880 100101968 89 + 1.642 1.670 0.094
ENSG00000221838 E015 2.4993518 0.0341245961 0.8295961358 0.893015626 7 100101969 100101989 21 + 0.437 0.480 0.220
ENSG00000221838 E016 1.1103491 0.3633459684 0.2616771902 0.399345556 7 100101990 100102060 71 + 0.438 0.200 -1.576
ENSG00000221838 E017 1.1103491 0.3633459684 0.2616771902 0.399345556 7 100102061 100102085 25 + 0.438 0.200 -1.576
ENSG00000221838 E018 7.8634057 0.0506436304 0.1184807274 0.217759889 7 100102086 100102245 160 + 1.035 0.804 -0.874
ENSG00000221838 E019 14.4758958 0.0012829860 0.0240005977 0.059813479 7 100102246 100102393 148 + 1.264 1.051 -0.761
ENSG00000221838 E020 64.6001532 0.0004674389 0.9418359306 0.967430214 7 100102675 100102746 72 + 1.715 1.721 0.020
ENSG00000221838 E021 52.9169412 0.0020178180 0.2002330984 0.326520850 7 100102747 100102781 35 + 1.696 1.624 -0.245
ENSG00000221838 E022 68.3828252 0.0006300583 0.0347328347 0.081137548 7 100102864 100102960 97 + 1.826 1.726 -0.339
ENSG00000221838 E023 1.1374321 0.0133997323 0.0089905128 0.026256389 7 100103228 100103408 181 + 0.590 0.136 -2.982
ENSG00000221838 E024 76.4379022 0.0003998424 0.0031258911 0.010635800 7 100103409 100103519 111 + 1.895 1.764 -0.442
ENSG00000221838 E025 0.0000000       7 100103568 100103611 44 +      
ENSG00000221838 E026 67.0286330 0.0003957635 0.9146021660 0.949953325 7 100103612 100103692 81 + 1.744 1.740 -0.011
ENSG00000221838 E027 53.0150259 0.0027305042 0.2692749389 0.407777151 7 100104092 100104154 63 + 1.587 1.659 0.245
ENSG00000221838 E028 67.8901938 0.0007069040 0.4422001257 0.583854480 7 100104874 100104940 67 + 1.706 1.748 0.143
ENSG00000221838 E029 80.6775784 0.0008787958 0.0321042040 0.076058840 7 100105045 100105098 54 + 1.725 1.834 0.370
ENSG00000221838 E030 64.8525379 0.0004462587 0.1901132812 0.313920307 7 100105240 100105256 17 + 1.664 1.736 0.244
ENSG00000221838 E031 103.6870437 0.0025117162 0.4829083035 0.621019783 7 100105257 100105335 79 + 1.895 1.931 0.120
ENSG00000221838 E032 69.3524573 0.0065265101 0.7640173575 0.847190464 7 100105336 100105346 11 + 1.735 1.757 0.076
ENSG00000221838 E033 102.8727585 0.0003466259 0.7153415075 0.811276681 7 100105445 100105539 95 + 1.908 1.925 0.057
ENSG00000221838 E034 57.0539907 0.0261330995 0.4852964983 0.623190660 7 100105959 100105976 18 + 1.625 1.687 0.209
ENSG00000221838 E035 53.5419661 0.0072874659 0.3723142686 0.516776722 7 100105977 100106003 27 + 1.594 1.658 0.220
ENSG00000221838 E036 11.0464543 0.0018488599 0.0001694596 0.000832757 7 100106004 100106240 237 + 1.264 0.880 -1.398
ENSG00000221838 E037 56.6917128 0.0028460482 0.5846725733 0.708538873 7 100106241 100106291 51 + 1.642 1.678 0.123
ENSG00000221838 E038 89.6971973 0.0056456659 0.3226806428 0.466014726 7 100106403 100106514 112 + 1.819 1.879 0.203
ENSG00000221838 E039 104.2237492 0.0005633168 0.2039687318 0.331146592 7 100106658 100106780 123 + 1.886 1.941 0.188
ENSG00000221838 E040 110.2304735 0.0017187311 0.4356352696 0.577850716 7 100106781 100106912 132 + 1.926 1.963 0.125
ENSG00000221838 E041 117.4735144 0.0055102131 0.6228200031 0.739544590 7 100106913 100108563 1651 + 1.958 1.988 0.104
ENSG00000221838 E042 11.8025346 0.0279392111 0.9536100378 0.974946497 7 100108564 100109039 476 + 1.012 1.018 0.023
ENSG00000221838 E043 7.5246958 0.0083722982 0.5997170417 0.721069498 7 100109681 100110190 510 + 0.793 0.869 0.297
ENSG00000221838 E044 2.5044232 0.0174823918 0.8079448089 0.877955642 7 100110191 100110345 155 + 0.520 0.478 -0.205