ENSG00000221838

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-7 / 7
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC

ENST00000359593	ENSG00000221838	HEK293_OSMI2_2hA	HEK293_TMG_2hB	AP4M1	protein_coding	protein_coding	10.96696	17.10069	6.791365	1.425157	0.3585234	-1.331002	0.5547459	0.2687660	0.3092010	0.26876599	0.1738056	0.1954108	0.05272917	0.01393333	0.04526667	0.03133333	0.531012370	0.009696549	FALSE
ENST00000421755	ENSG00000221838	HEK293_OSMI2_2hA	HEK293_TMG_2hB	AP4M1	protein_coding	protein_coding	10.96696	17.10069	6.791365	1.425157	0.3585234	-1.331002	4.3053428	7.0485826	1.6077897	1.06460520	0.8210326	-2.1253544	0.37824583	0.42023333	0.24430000	-0.17593333	0.706463692	0.009696549	FALSE
ENST00000422582	ENSG00000221838	HEK293_OSMI2_2hA	HEK293_TMG_2hB	AP4M1	protein_coding	protein_coding	10.96696	17.10069	6.791365	1.425157	0.3585234	-1.331002	0.7991870	1.5710041	0.7098318	0.11271083	0.1163030	-1.1351094	0.07199167	0.09393333	0.10463333	0.01070000	0.902658764	0.009696549	FALSE
ENST00000438383	ENSG00000221838	HEK293_OSMI2_2hA	HEK293_TMG_2hB	AP4M1	protein_coding	protein_coding	10.96696	17.10069	6.791365	1.425157	0.3585234	-1.331002	0.8479805	1.1928750	0.9391422	0.71963243	0.2724129	-0.3417905	0.07725417	0.06816667	0.13470000	0.06653333	0.652688570	0.009696549	FALSE
ENST00000463195	ENSG00000221838	HEK293_OSMI2_2hA	HEK293_TMG_2hB	AP4M1	protein_coding	retained_intron	10.96696	17.10069	6.791365	1.425157	0.3585234	-1.331002	0.5195692	0.4752147	0.3085974	0.13352900	0.1818431	-0.6068887	0.05084583	0.02723333	0.04290000	0.01566667	0.996376543	0.009696549	TRUE
ENST00000489387	ENSG00000221838	HEK293_OSMI2_2hA	HEK293_TMG_2hB	AP4M1	protein_coding	retained_intron	10.96696	17.10069	6.791365	1.425157	0.3585234	-1.331002	0.9701813	1.1594977	0.9898538	0.07680305	0.1840811	-0.2260999	0.09994583	0.06803333	0.14433333	0.07630000	0.009696549	0.009696549
MSTRG.30327.1	ENSG00000221838	HEK293_OSMI2_2hA	HEK293_TMG_2hB	AP4M1	protein_coding		10.96696	17.10069	6.791365	1.425157	0.3585234	-1.331002	0.5221558	0.5510242	0.7752483	0.55102419	0.7752483	0.4850859	0.05141667	0.02856667	0.11136667	0.08280000	0.952406373	0.009696549	FALSE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 44
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000221838	E001	3.1540389	0.1278857258	0.1540215381	0.267142607	7	100100994	100101051	58	+	0.750	0.480	-1.196
ENSG00000221838	E002	3.0989308	0.0051228855	0.1645088211	0.281039530	7	100101472	100101496	25	+	0.703	0.479	-1.009
ENSG00000221838	E003	1.1049513	0.0734186795	0.0813906157	0.161735420	7	100101549	100101556	8	+	0.520	0.190	-2.080
ENSG00000221838	E004	2.7634363	0.1359511396	0.0284808076	0.068975753	7	100101557	100101590	34	+	0.831	0.385	-2.020
ENSG00000221838	E005	5.6032680	0.0144063687	0.0811453212	0.161330902	7	100101591	100101635	45	+	0.931	0.684	-0.973
ENSG00000221838	E006	5.6774642	0.0036551894	0.1431193696	0.252271304	7	100101636	100101642	7	+	0.900	0.701	-0.788
ENSG00000221838	E007	7.7674254	0.0022195437	0.0515175243	0.111850380	7	100101643	100101658	16	+	1.035	0.800	-0.891
ENSG00000221838	E008	9.2263564	0.0232243958	0.7131148717	0.809650502	7	100101659	100101663	5	+	0.959	0.913	-0.174
ENSG00000221838	E009	16.7422312	0.0013216772	0.4830345288	0.621123081	7	100101664	100101707	44	+	1.205	1.140	-0.232
ENSG00000221838	E010	40.6240921	0.0008560635	0.5514436762	0.680902851	7	100101708	100101768	61	+	1.553	1.517	-0.124
ENSG00000221838	E011	31.8925704	0.0009693056	0.7851214237	0.862244486	7	100101769	100101772	4	+	1.403	1.426	0.077
ENSG00000221838	E012	0.2934659	0.0293276146	0.3984097252		7	100101773	100101865	93	+	0.198	0.073	-1.664
ENSG00000221838	E013	0.8919372	0.3434310316	0.5377246052	0.669244556	7	100101866	100101879	14	+	0.334	0.229	-0.744
ENSG00000221838	E014	56.5848948	0.0021141187	0.6720995168	0.778188713	7	100101880	100101968	89	+	1.642	1.670	0.094
ENSG00000221838	E015	2.4993518	0.0341245961	0.8295961358	0.893015626	7	100101969	100101989	21	+	0.437	0.480	0.220
ENSG00000221838	E016	1.1103491	0.3633459684	0.2616771902	0.399345556	7	100101990	100102060	71	+	0.438	0.200	-1.576
ENSG00000221838	E017	1.1103491	0.3633459684	0.2616771902	0.399345556	7	100102061	100102085	25	+	0.438	0.200	-1.576
ENSG00000221838	E018	7.8634057	0.0506436304	0.1184807274	0.217759889	7	100102086	100102245	160	+	1.035	0.804	-0.874
ENSG00000221838	E019	14.4758958	0.0012829860	0.0240005977	0.059813479	7	100102246	100102393	148	+	1.264	1.051	-0.761
ENSG00000221838	E020	64.6001532	0.0004674389	0.9418359306	0.967430214	7	100102675	100102746	72	+	1.715	1.721	0.020
ENSG00000221838	E021	52.9169412	0.0020178180	0.2002330984	0.326520850	7	100102747	100102781	35	+	1.696	1.624	-0.245
ENSG00000221838	E022	68.3828252	0.0006300583	0.0347328347	0.081137548	7	100102864	100102960	97	+	1.826	1.726	-0.339
ENSG00000221838	E023	1.1374321	0.0133997323	0.0089905128	0.026256389	7	100103228	100103408	181	+	0.590	0.136	-2.982
ENSG00000221838	E024	76.4379022	0.0003998424	0.0031258911	0.010635800	7	100103409	100103519	111	+	1.895	1.764	-0.442
ENSG00000221838	E025	0.0000000				7	100103568	100103611	44	+
ENSG00000221838	E026	67.0286330	0.0003957635	0.9146021660	0.949953325	7	100103612	100103692	81	+	1.744	1.740	-0.011
ENSG00000221838	E027	53.0150259	0.0027305042	0.2692749389	0.407777151	7	100104092	100104154	63	+	1.587	1.659	0.245
ENSG00000221838	E028	67.8901938	0.0007069040	0.4422001257	0.583854480	7	100104874	100104940	67	+	1.706	1.748	0.143
ENSG00000221838	E029	80.6775784	0.0008787958	0.0321042040	0.076058840	7	100105045	100105098	54	+	1.725	1.834	0.370
ENSG00000221838	E030	64.8525379	0.0004462587	0.1901132812	0.313920307	7	100105240	100105256	17	+	1.664	1.736	0.244
ENSG00000221838	E031	103.6870437	0.0025117162	0.4829083035	0.621019783	7	100105257	100105335	79	+	1.895	1.931	0.120
ENSG00000221838	E032	69.3524573	0.0065265101	0.7640173575	0.847190464	7	100105336	100105346	11	+	1.735	1.757	0.076
ENSG00000221838	E033	102.8727585	0.0003466259	0.7153415075	0.811276681	7	100105445	100105539	95	+	1.908	1.925	0.057
ENSG00000221838	E034	57.0539907	0.0261330995	0.4852964983	0.623190660	7	100105959	100105976	18	+	1.625	1.687	0.209
ENSG00000221838	E035	53.5419661	0.0072874659	0.3723142686	0.516776722	7	100105977	100106003	27	+	1.594	1.658	0.220
ENSG00000221838	E036	11.0464543	0.0018488599	0.0001694596	0.000832757	7	100106004	100106240	237	+	1.264	0.880	-1.398
ENSG00000221838	E037	56.6917128	0.0028460482	0.5846725733	0.708538873	7	100106241	100106291	51	+	1.642	1.678	0.123
ENSG00000221838	E038	89.6971973	0.0056456659	0.3226806428	0.466014726	7	100106403	100106514	112	+	1.819	1.879	0.203
ENSG00000221838	E039	104.2237492	0.0005633168	0.2039687318	0.331146592	7	100106658	100106780	123	+	1.886	1.941	0.188
ENSG00000221838	E040	110.2304735	0.0017187311	0.4356352696	0.577850716	7	100106781	100106912	132	+	1.926	1.963	0.125
ENSG00000221838	E041	117.4735144	0.0055102131	0.6228200031	0.739544590	7	100106913	100108563	1651	+	1.958	1.988	0.104
ENSG00000221838	E042	11.8025346	0.0279392111	0.9536100378	0.974946497	7	100108564	100109039	476	+	1.012	1.018	0.023
ENSG00000221838	E043	7.5246958	0.0083722982	0.5997170417	0.721069498	7	100109681	100110190	510	+	0.793	0.869	0.297
ENSG00000221838	E044	2.5044232	0.0174823918	0.8079448089	0.877955642	7	100110191	100110345	155	+	0.520	0.478	-0.205

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000221838

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3