ENSG00000221817

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000422977 ENSG00000221817 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP3CB-AS1 lncRNA lncRNA 1.380112 1.310048 1.5211 0.03950572 0.1022581 0.2139774 0.12924566 0.01805843 0.18444277 0.009183524 0.09353452 2.7928393 0.10422083 0.01356667 0.12220000 0.10863333 2.711371e-01 4.915384e-07 FALSE TRUE
ENST00000439792 ENSG00000221817 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP3CB-AS1 lncRNA retained_intron 1.380112 1.310048 1.5211 0.03950572 0.1022581 0.2139774 0.07537765 0.00000000 0.04662711 0.000000000 0.04662711 2.5014928 0.05462500 0.00000000 0.03536667 0.03536667 8.200598e-01 4.915384e-07   FALSE
ENST00000442133 ENSG00000221817 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP3CB-AS1 lncRNA lncRNA 1.380112 1.310048 1.5211 0.03950572 0.1022581 0.2139774 0.21651097 0.08510881 0.26310386 0.042596078 0.13202638 1.5217989 0.15976250 0.06356667 0.16210000 0.09853333 8.215406e-01 4.915384e-07 FALSE FALSE
ENST00000600607 ENSG00000221817 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP3CB-AS1 lncRNA lncRNA 1.380112 1.310048 1.5211 0.03950572 0.1022581 0.2139774 0.07370702 0.07431137 0.10130425 0.009910693 0.01247418 0.4007096 0.05263333 0.05640000 0.06843333 0.01203333 9.173595e-01 4.915384e-07   FALSE
ENST00000600887 ENSG00000221817 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP3CB-AS1 lncRNA lncRNA 1.380112 1.310048 1.5211 0.03950572 0.1022581 0.2139774 0.22690102 0.28398279 0.05937037 0.056887244 0.05937037 -2.0833401 0.17879583 0.21936667 0.03716667 -0.18220000 1.188679e-01 4.915384e-07   FALSE
ENST00000620302 ENSG00000221817 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP3CB-AS1 lncRNA lncRNA 1.380112 1.310048 1.5211 0.03950572 0.1022581 0.2139774 0.02835687 0.02353089 0.10841521 0.011778329 0.07722208 1.8202918 0.02097500 0.01760000 0.07926667 0.06166667 7.384118e-01 4.915384e-07 FALSE TRUE
ENST00000620559 ENSG00000221817 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP3CB-AS1 lncRNA lncRNA 1.380112 1.310048 1.5211 0.03950572 0.1022581 0.2139774 0.13410728 0.21958833 0.12083776 0.065182652 0.09353640 -0.8112703 0.09922917 0.17073333 0.08873333 -0.08200000 5.322584e-01 4.915384e-07 FALSE TRUE
ENST00000687563 ENSG00000221817 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP3CB-AS1 lncRNA lncRNA 1.380112 1.310048 1.5211 0.03950572 0.1022581 0.2139774 0.07955458 0.27195342 0.00000000 0.032142075 0.00000000 -4.8173850 0.05713333 0.20666667 0.00000000 -0.20666667 4.915384e-07 4.915384e-07   FALSE
ENST00000690300 ENSG00000221817 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP3CB-AS1 lncRNA lncRNA 1.380112 1.310048 1.5211 0.03950572 0.1022581 0.2139774 0.11957473 0.00000000 0.18240650 0.000000000 0.18240650 4.2660857 0.06313333 0.00000000 0.11073333 0.11073333 8.376635e-01 4.915384e-07   FALSE
ENST00000690541 ENSG00000221817 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP3CB-AS1 lncRNA lncRNA 1.380112 1.310048 1.5211 0.03950572 0.1022581 0.2139774 0.08271389 0.09301211 0.20683976 0.048756124 0.06323152 1.0738154 0.06331250 0.07006667 0.14333333 0.07326667 6.605681e-01 4.915384e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000221817 E001 0.3666179 0.028714031 0.87547408 0.92403632 10 73495525 73495667 143 + 0.112 0.134 0.291
ENSG00000221817 E002 0.4407149 0.023470885 0.69561182 0.79617632 10 73495668 73495702 35 + 0.201 0.133 -0.714
ENSG00000221817 E003 0.8438645 0.014565748 0.49641040 0.63307614 10 73495703 73495719 17 + 0.201 0.318 0.874
ENSG00000221817 E004 0.8438645 0.014565748 0.49641040 0.63307614 10 73495720 73495720 1 + 0.201 0.318 0.874
ENSG00000221817 E005 0.8438645 0.014565748 0.49641040 0.63307614 10 73495721 73495721 1 + 0.201 0.318 0.874
ENSG00000221817 E006 2.7355352 0.005897979 0.35497735 0.49931984 10 73495722 73495752 31 + 0.486 0.627 0.652
ENSG00000221817 E007 2.5903625 0.007841363 0.23701431 0.37072343 10 73495753 73495754 2 + 0.442 0.627 0.874
ENSG00000221817 E008 7.9006682 0.063064960 0.27112046 0.40982500 10 73495755 73495817 63 + 0.839 1.013 0.657
ENSG00000221817 E009 13.4903876 0.001532100 0.04366308 0.09776665 10 73496142 73496286 145 + 1.065 1.235 0.610
ENSG00000221817 E010 3.4689149 0.078382872 0.33465623 0.47839743 10 73496287 73496289 3 + 0.734 0.546 -0.812
ENSG00000221817 E011 3.4689149 0.078382872 0.33465623 0.47839743 10 73496290 73496290 1 + 0.734 0.546 -0.812
ENSG00000221817 E012 3.6204304 0.087256474 0.29129308 0.43214590 10 73496291 73496295 5 + 0.757 0.546 -0.906
ENSG00000221817 E013 11.1225963 0.005994442 0.49868673 0.63511980 10 73496296 73496483 188 + 1.116 1.044 -0.261
ENSG00000221817 E014 5.7185439 0.003135241 0.57642022 0.70186014 10 73496484 73496608 125 + 0.856 0.781 -0.296
ENSG00000221817 E015 7.5524766 0.050583396 0.93556343 0.96343718 10 73496609 73496906 298 + 0.922 0.934 0.048
ENSG00000221817 E016 1.8038441 0.012109624 0.73562902 0.82634768 10 73496907 73496937 31 + 0.393 0.448 0.293
ENSG00000221817 E017 1.0059890 0.015430442 0.79133829 0.86654027 10 73498298 73498555 258 + 0.275 0.318 0.288
ENSG00000221817 E018 0.4513240 0.106215074 0.72152873 0.81585321 10 73498556 73498649 94 + 0.201 0.133 -0.723
ENSG00000221817 E019 1.7015603 0.008968325 0.73473012 0.82563167 10 73498650 73498732 83 + 0.393 0.447 0.289
ENSG00000221817 E020 2.8786446 0.005848596 0.49516049 0.63201147 10 73498733 73498867 135 + 0.526 0.627 0.459
ENSG00000221817 E021 13.3880526 0.001440900 0.11868869 0.21806807 10 73499595 73499687 93 + 1.086 1.217 0.466
ENSG00000221817 E022 2.1003418 0.007243862 0.03393080 0.07961368 10 73499688 73499926 239 + 0.275 0.627 1.874
ENSG00000221817 E023 11.2247791 0.029993532 0.47562253 0.61433145 10 73504184 73504272 89 + 1.054 1.138 0.304
ENSG00000221817 E024 0.8200183 0.015800190 0.83679031 0.89793321 10 73504538 73504542 5 + 0.275 0.235 -0.297
ENSG00000221817 E025 3.4330836 0.034427955 0.79266010 0.86743616 10 73504543 73504614 72 + 0.627 0.663 0.151
ENSG00000221817 E026 4.0543570 0.130947330 0.51402033 0.64877915 10 73504615 73504804 190 + 0.656 0.751 0.394
ENSG00000221817 E027 5.9226281 0.006283469 0.06802396 0.14008604 10 73504805 73504911 107 + 0.938 0.695 -0.952
ENSG00000221817 E028 8.7067771 0.002097780 0.12166327 0.22230867 10 73504912 73505277 366 + 1.065 0.894 -0.634
ENSG00000221817 E029 31.4934774 0.014086026 0.05227801 0.11321603 10 73505278 73507309 2032 + 1.581 1.437 -0.494
ENSG00000221817 E030 0.0000000       10 73513210 73513474 265 +      
ENSG00000221817 E031 0.0000000       10 73515828 73515925 98 +      
ENSG00000221817 E032 0.0000000       10 73518744 73518864 121 +      
ENSG00000221817 E033 0.0000000       10 73519608 73520070 463 +