ENSG00000218739

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392061 ENSG00000218739 HEK293_OSMI2_2hA HEK293_TMG_2hB CEBPZOS protein_coding protein_coding 30.17337 24.96382 38.87009 2.238887 1.892338 0.638615 12.420952 14.4181400 9.399338 1.29820903 0.6115927 -0.6167203 0.45368750 0.57783333 0.24203333 -0.33580000 1.035493e-25 1.035493e-25   FALSE
ENST00000402297 ENSG00000218739 HEK293_OSMI2_2hA HEK293_TMG_2hB CEBPZOS protein_coding protein_coding 30.17337 24.96382 38.87009 2.238887 1.892338 0.638615 13.586187 8.5593965 21.607880 1.35529312 0.9552754 1.3349595 0.41327083 0.33916667 0.55626667 0.21710000 3.430758e-05 1.035493e-25   FALSE
ENST00000406711 ENSG00000218739 HEK293_OSMI2_2hA HEK293_TMG_2hB CEBPZOS protein_coding protein_coding 30.17337 24.96382 38.87009 2.238887 1.892338 0.638615 1.621693 0.9239753 3.681080 0.08018903 0.6112182 1.9825867 0.04654167 0.03766667 0.09373333 0.05606667 3.082405e-03 1.035493e-25   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000218739 E001 0.9201396 0.0216452302 2.968141e-01 4.380896e-01 2 37196488 37196493 6 + 0.354 0.152 -1.584
ENSG00000218739 E002 1.2470166 0.0678701157 5.370544e-01 6.686998e-01 2 37196494 37196495 2 + 0.400 0.265 -0.847
ENSG00000218739 E003 26.1704747 0.0007852576 1.504784e-01 2.623398e-01 2 37196496 37196504 9 + 1.477 1.358 -0.411
ENSG00000218739 E004 59.0808085 0.0034896415 4.450098e-02 9.928723e-02 2 37196505 37196507 3 + 1.737 1.820 0.281
ENSG00000218739 E005 120.8330941 0.0019464322 3.962915e-02 9.034118e-02 2 37196508 37196520 13 + 2.056 2.110 0.182
ENSG00000218739 E006 2.4723640 0.0059743036 1.254528e-01 2.277983e-01 2 37196523 37196669 147 + 0.631 0.354 -1.381
ENSG00000218739 E007 4.5953956 0.0368376279 8.742037e-01 9.231159e-01 2 37197254 37197350 97 + 0.743 0.749 0.024
ENSG00000218739 E008 14.7361842 0.0082172898 3.601433e-01 5.044552e-01 2 37198494 37198672 179 + 1.234 1.120 -0.406
ENSG00000218739 E009 237.6203279 0.0002115790 1.256793e-01 2.281133e-01 2 37199704 37199819 116 + 2.367 2.382 0.051
ENSG00000218739 E010 216.2376767 0.0002504426 6.022286e-01 7.232172e-01 2 37201048 37201092 45 + 2.336 2.330 -0.022
ENSG00000218739 E011 8.6708171 0.0022352858 6.773149e-03 2.063311e-02 2 37201093 37201641 549 + 1.092 0.750 -1.298
ENSG00000218739 E012 221.6851732 0.0019187110 1.624858e-01 2.783802e-01 2 37201642 37201726 85 + 2.336 2.359 0.076
ENSG00000218739 E013 514.2720264 0.0007396745 8.127299e-11 1.455974e-09 2 37201863 37203249 1387 + 2.760 2.623 -0.457
ENSG00000218739 E014 563.2192321 0.0028082493 4.366159e-05 2.495191e-04 2 37203250 37204303 1054 + 2.793 2.675 -0.392
ENSG00000218739 E015 275.1214077 0.0003088803 6.420434e-44 2.783368e-41 2 37204304 37204743 440 + 2.303 2.579 0.922
ENSG00000218739 E016 2.0982575 0.0080553210 2.273499e-01 3.592313e-01 2 37213437 37213466 30 + 0.577 0.354 -1.141
ENSG00000218739 E017 3.5322891 0.0118080859 5.586645e-01 6.868764e-01 2 37213467 37213554 88 + 0.702 0.595 -0.460
ENSG00000218739 E018 1.4048748 0.0501461701 3.999388e-01 5.436642e-01 2 37213555 37213725 171 + 0.442 0.265 -1.072
ENSG00000218739 E019 4.3942382 0.0036308200 6.339574e-01 7.485373e-01 2 37215321 37215518 198 + 0.763 0.679 -0.344
ENSG00000218739 E020 1.1071545 0.0122511490 7.304978e-01 8.224408e-01 2 37216113 37216193 81 + 0.303 0.354 0.319