ENSG00000218336

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000502950 ENSG00000218336 HEK293_OSMI2_2hA HEK293_TMG_2hB TENM3 protein_coding processed_transcript 4.763323 3.273773 6.599304 0.3305489 0.2316787 1.009144 0.5989998 0.02251254 1.1715613 0.02251254 0.20542690 5.1835542 0.09403750 0.005766667 0.17616667 0.17040000 2.186928e-07 2.186928e-07 FALSE TRUE
ENST00000513201 ENSG00000218336 HEK293_OSMI2_2hA HEK293_TMG_2hB TENM3 protein_coding processed_transcript 4.763323 3.273773 6.599304 0.3305489 0.2316787 1.009144 0.2707881 0.38587989 0.4767060 0.05268474 0.04054524 0.2979877 0.05975833 0.117166667 0.07246667 -0.04470000 2.879680e-01 2.186928e-07 FALSE TRUE
MSTRG.25768.10 ENSG00000218336 HEK293_OSMI2_2hA HEK293_TMG_2hB TENM3 protein_coding   4.763323 3.273773 6.599304 0.3305489 0.2316787 1.009144 0.9818642 0.60492159 0.9287696 0.60492159 0.92876961 0.6103687 0.21654167 0.154700000 0.15040000 -0.00430000 9.428607e-01 2.186928e-07 FALSE TRUE
MSTRG.25768.11 ENSG00000218336 HEK293_OSMI2_2hA HEK293_TMG_2hB TENM3 protein_coding   4.763323 3.273773 6.599304 0.3305489 0.2316787 1.009144 1.4502801 1.69715842 1.4828518 0.28845398 0.74488314 -0.1935260 0.34005000 0.542600000 0.21753333 -0.32506667 5.064133e-01 2.186928e-07 FALSE TRUE
MSTRG.25768.6 ENSG00000218336 HEK293_OSMI2_2hA HEK293_TMG_2hB TENM3 protein_coding   4.763323 3.273773 6.599304 0.3305489 0.2316787 1.009144 0.4245447 0.18013161 0.9354848 0.18013161 0.50809405 2.3140558 0.06839167 0.057900000 0.14476667 0.08686667 6.339505e-01 2.186928e-07 FALSE TRUE
MSTRG.25768.9 ENSG00000218336 HEK293_OSMI2_2hA HEK293_TMG_2hB TENM3 protein_coding   4.763323 3.273773 6.599304 0.3305489 0.2316787 1.009144 0.5031645 0.14969569 0.7429157 0.14969569 0.38674202 2.2371630 0.11913333 0.053466667 0.10970000 0.05623333 4.560506e-01 2.186928e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000218336 E001 2.1735956 0.0672430117 1.437740e-01 2.531466e-01 4 182143987 182144000 14 + 0.325 0.643 1.605
ENSG00000218336 E002 2.6143105 0.0068764956 1.534724e-01 2.663780e-01 4 182144001 182144046 46 + 0.408 0.682 1.287
ENSG00000218336 E003 4.7814641 0.0147853938 1.240368e-01 2.257247e-01 4 182144047 182144161 115 + 0.615 0.886 1.100
ENSG00000218336 E004 0.8544736 0.0168132502 2.630850e-01 4.009417e-01 4 182144639 182144689 51 + 0.160 0.385 1.677
ENSG00000218336 E005 0.8544736 0.0168132502 2.630850e-01 4.009417e-01 4 182144690 182144694 5 + 0.160 0.385 1.677
ENSG00000218336 E006 1.2973640 0.1308948778 8.199061e-02 1.626666e-01 4 182144695 182144721 27 + 0.160 0.534 2.438
ENSG00000218336 E007 2.1058427 0.1622952911 3.942638e-01 5.381240e-01 4 182144722 182144754 33 + 0.369 0.595 1.136
ENSG00000218336 E008 0.0000000       4 182243402 182243476 75 +      
ENSG00000218336 E009 3.0906161 0.0052448504 7.555386e-01 8.408450e-01 4 182323946 182323977 32 + 0.591 0.586 -0.022
ENSG00000218336 E010 14.9531407 0.0011486323 3.600507e-02 8.359439e-02 4 182323978 182324252 275 + 1.232 1.094 -0.493
ENSG00000218336 E011 16.5613644 0.0010791517 3.080958e-02 7.354539e-02 4 182346651 182346929 279 + 1.275 1.141 -0.475
ENSG00000218336 E012 5.9849795 0.0028465653 1.795777e-01 3.006091e-01 4 182349841 182350316 476 + 0.737 0.958 0.857
ENSG00000218336 E013 0.0000000       4 182448822 182448991 170 +      
ENSG00000218336 E014 0.0000000       4 182448992 182448998 7 +      
ENSG00000218336 E015 5.1117869 0.0561168879 1.089858e-02 3.091939e-02 4 182448999 182449083 85 + 0.885 0.462 -1.814
ENSG00000218336 E016 20.9974796 0.0126028884 5.648799e-05 3.140540e-04 4 182600924 182601161 238 + 1.425 1.076 -1.230
ENSG00000218336 E017 31.6668112 0.0013356312 6.927073e-11 1.255802e-09 4 182628651 182628889 239 + 1.609 1.183 -1.476
ENSG00000218336 E018 27.0638227 0.0009909757 4.754887e-10 7.471791e-09 4 182653771 182653893 123 + 1.545 1.110 -1.521
ENSG00000218336 E019 28.9273037 0.0007334264 1.410686e-07 1.392944e-06 4 182673005 182673219 215 + 1.551 1.222 -1.139
ENSG00000218336 E020 23.9034458 0.0008353740 2.095975e-05 1.293998e-04 4 182679666 182679876 211 + 1.460 1.183 -0.967
ENSG00000218336 E021 14.8850102 0.0012314980 5.492391e-03 1.726713e-02 4 182680248 182680323 76 + 1.248 1.041 -0.744
ENSG00000218336 E022 12.8470183 0.0017668633 1.815461e-02 4.746333e-02 4 182680324 182680349 26 + 1.184 1.001 -0.660
ENSG00000218336 E023 0.0000000       4 182680372 182680542 171 +      
ENSG00000218336 E024 30.3125756 0.0030674476 3.214059e-03 1.089723e-02 4 182680543 182680737 195 + 1.523 1.369 -0.529
ENSG00000218336 E025 39.5896359 0.0076814081 8.161242e-05 4.356257e-04 4 182681814 182682014 201 + 1.659 1.427 -0.792
ENSG00000218336 E026 36.1598946 0.0173698099 6.840994e-03 2.081302e-02 4 182688166 182688351 186 + 1.612 1.432 -0.619
ENSG00000218336 E027 30.2330563 0.0007158838 6.935113e-03 2.105541e-02 4 182714087 182714233 147 + 1.517 1.394 -0.424
ENSG00000218336 E028 43.1129776 0.0005707833 1.786746e-03 6.556652e-03 4 182728965 182729181 217 + 1.665 1.547 -0.403
ENSG00000218336 E029 28.0716993 0.0096599444 2.820184e-02 6.841529e-02 4 182730200 182730319 120 + 1.483 1.362 -0.419
ENSG00000218336 E030 51.7048703 0.0004881285 3.984461e-06 2.900124e-05 4 182730878 182731139 262 + 1.761 1.575 -0.629
ENSG00000218336 E031 51.3965910 0.0004662239 8.359814e-05 4.450463e-04 4 182736808 182737075 268 + 1.749 1.602 -0.498
ENSG00000218336 E032 33.2792984 0.0006609550 1.779947e-02 4.670521e-02 4 182738401 182738544 144 + 1.548 1.456 -0.316
ENSG00000218336 E033 43.5618564 0.0303385727 7.325262e-03 2.206489e-02 4 182743170 182743419 250 + 1.691 1.497 -0.663
ENSG00000218336 E034 2.5280126 0.0390780986 5.795998e-02 1.231367e-01 4 182744143 182744163 21 + 0.615 0.291 -1.709
ENSG00000218336 E035 12.5665421 0.0096742775 1.237600e-03 4.767864e-03 4 182751800 182751802 3 + 1.202 0.885 -1.162
ENSG00000218336 E036 39.6119338 0.0005503279 7.682645e-07 6.542248e-06 4 182751803 182752032 230 + 1.663 1.418 -0.838
ENSG00000218336 E037 30.8054483 0.0006679193 3.419497e-05 2.005055e-04 4 182753450 182753604 155 + 1.556 1.331 -0.776
ENSG00000218336 E038 119.1644582 0.0003292276 1.937603e-04 9.371282e-04 4 182754385 182755259 875 + 2.086 2.021 -0.218
ENSG00000218336 E039 0.9652040 0.2593181328 9.252377e-01 9.569385e-01 4 182755260 182755353 94 + 0.278 0.291 0.094
ENSG00000218336 E040 50.1369848 0.0005453695 2.911953e-03 1.000509e-02 4 182773472 182773647 176 + 1.724 1.627 -0.329
ENSG00000218336 E041 69.1464344 0.0003663032 7.237810e-02 1.473011e-01 4 182774918 182775153 236 + 1.833 1.814 -0.064
ENSG00000218336 E042 70.4898915 0.0003497635 6.223471e-01 7.391638e-01 4 182789093 182789389 297 + 1.823 1.862 0.131
ENSG00000218336 E043 279.7925842 0.0012848787 1.724109e-13 4.744042e-12 4 182792274 182793885 1612 + 2.327 2.567 0.799
ENSG00000218336 E044 58.8206568 0.0017575710 1.627732e-10 2.771108e-09 4 182796637 182796767 131 + 1.582 1.954 1.258
ENSG00000218336 E045 312.4272743 0.0058288938 5.420550e-26 6.474823e-24 4 182799596 182803024 3429 + 2.268 2.704 1.454