ENSG00000215417

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000385233 ENSG00000215417 HEK293_OSMI2_2hA HEK293_TMG_2hB MIR17HG lncRNA miRNA 16.41624 6.88167 19.95458 1.03589 0.9952529 1.534517 6.676973 1.592935 8.999375 0.2744535 0.5033708 2.490711 0.3707167 0.2399667 0.4518000 0.2118333 0.01070850 0.0107085   FALSE
ENST00000664987 ENSG00000215417 HEK293_OSMI2_2hA HEK293_TMG_2hB MIR17HG lncRNA lncRNA 16.41624 6.88167 19.95458 1.03589 0.9952529 1.534517 9.176066 4.777946 10.400183 0.9606389 0.7561174 1.120517 0.5839583 0.6824000 0.5211333 -0.1612667 0.07472634 0.0107085   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000215417 E001 2.3197278 0.0080241170 3.683734e-01 5.127908e-01 13 91347820 91347941 122 + 0.473 0.590 0.552
ENSG00000215417 E002 1.4800134 0.0095033433 2.099409e-02 5.357744e-02 13 91347942 91347959 18 + 0.220 0.590 2.137
ENSG00000215417 E003 2.0753511 0.0202236739 2.121264e-02 5.403981e-02 13 91349118 91349337 220 + 0.322 0.685 1.810
ENSG00000215417 E004 3.0549356 0.0053226877 1.803604e-04 8.795719e-04 13 91349698 91349770 73 + 0.322 0.862 2.517
ENSG00000215417 E005 0.8836053 0.0151256973 1.551380e-01 2.685750e-01 13 91349771 91350155 385 + 0.158 0.389 1.725
ENSG00000215417 E006 3.6869067 0.0046215022 8.969530e-04 3.603472e-03 13 91350156 91350226 71 + 0.440 0.890 1.945
ENSG00000215417 E007 2.0647525 0.0074889718 5.892518e-06 4.128097e-05 13 91350227 91350604 378 + 0.086 0.800 4.596
ENSG00000215417 E008 0.1451727 0.0437653508 1.000000e+00   13 91350605 91350750 146 + 0.086 0.000 -7.776
ENSG00000215417 E009 0.3268771 0.0332948484 5.072071e-01   13 91350751 91350890 140 + 0.086 0.171 1.139
ENSG00000215417 E010 0.7019140 0.0175013857 3.796222e-01 5.238841e-01 13 91350891 91351064 174 + 0.158 0.294 1.140
ENSG00000215417 E011 0.8232405 0.1182559360 6.998069e-01 7.994327e-01 13 91351065 91351191 127 + 0.274 0.172 -0.853
ENSG00000215417 E012 1.1156622 0.0116275066 3.667280e-01 5.110757e-01 13 91351192 91351313 122 + 0.365 0.171 -1.446
ENSG00000215417 E013 145.1457574 0.0069018458 9.357916e-13 2.308371e-11 13 91351314 91352402 1089 + 2.236 1.904 -1.113
ENSG00000215417 E014 30.5049704 0.0015597432 4.384916e-02 9.810907e-02 13 91352584 91352630 47 + 1.539 1.356 -0.628
ENSG00000215417 E015 32.9120510 0.0006708655 1.204837e-02 3.364953e-02 13 91353918 91353932 15 + 1.470 1.576 0.364
ENSG00000215417 E016 148.6101887 0.0003923950 7.399676e-11 1.333822e-09 13 91353933 91354579 647 + 2.116 2.224 0.361