ENSG00000215256

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399886 ENSG00000215256 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS4-AS1 lncRNA lncRNA 6.694635 5.281364 10.08828 0.4848279 0.3514494 0.9323983 0.3840995 0.1868321 1.1556350 0.1170199 0.5859551 2.5660788 0.05387083 0.03603333 0.11176667 0.07573333 0.813314548 0.001582892   FALSE
ENST00000555045 ENSG00000215256 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS4-AS1 lncRNA lncRNA 6.694635 5.281364 10.08828 0.4848279 0.3514494 0.9323983 1.8682485 2.3935931 1.5030733 0.4831228 0.3526811 -0.6677108 0.29393750 0.44513333 0.14983333 -0.29530000 0.001582892 0.001582892   FALSE
ENST00000556379 ENSG00000215256 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS4-AS1 lncRNA lncRNA 6.694635 5.281364 10.08828 0.4848279 0.3514494 0.9323983 3.0490818 1.5612480 5.7171198 0.1459442 0.3386841 1.8658989 0.42871667 0.30423333 0.57030000 0.26606667 0.016774382 0.001582892   FALSE
ENST00000666884 ENSG00000215256 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS4-AS1 lncRNA lncRNA 6.694635 5.281364 10.08828 0.4848279 0.3514494 0.9323983 0.4433424 0.3464123 0.2784065 0.1846523 0.2784065 -0.3054435 0.08529583 0.06166667 0.02826667 -0.03340000 0.535006313 0.001582892   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000215256 E001 0.0000000       14 23938219 23938730 512 -      
ENSG00000215256 E002 0.1482932 0.041159753 0.339788205   14 23938731 23938739 9 - 0.000 0.145 11.593
ENSG00000215256 E003 0.1482932 0.041159753 0.339788205   14 23938740 23938740 1 - 0.000 0.145 13.297
ENSG00000215256 E004 0.1482932 0.041159753 0.339788205   14 23938741 23938746 6 - 0.000 0.145 13.297
ENSG00000215256 E005 0.1482932 0.041159753 0.339788205   14 23938747 23938747 1 - 0.000 0.145 13.297
ENSG00000215256 E006 0.1482932 0.041159753 0.339788205   14 23938748 23938756 9 - 0.000 0.145 13.297
ENSG00000215256 E007 0.1482932 0.041159753 0.339788205   14 23938757 23938761 5 - 0.000 0.145 13.297
ENSG00000215256 E008 0.1482932 0.041159753 0.339788205   14 23938762 23938776 15 - 0.000 0.145 13.297
ENSG00000215256 E009 0.1482932 0.041159753 0.339788205   14 23938777 23938812 36 - 0.000 0.145 13.297
ENSG00000215256 E010 175.9728412 0.006308353 0.945692695 0.96993506 14 23938813 23939894 1082 - 2.244 2.256 0.041
ENSG00000215256 E011 118.6183824 0.005366308 0.035018122 0.08168940 14 23939895 23940215 321 - 2.034 2.130 0.324
ENSG00000215256 E012 118.9937611 0.003013263 0.112970692 0.20988074 14 23940216 23940650 435 - 2.050 2.116 0.221
ENSG00000215256 E013 43.0383837 0.008028323 0.516494142 0.65105005 14 23940651 23940685 35 - 1.660 1.622 -0.129
ENSG00000215256 E014 133.6736809 0.002105845 0.003270973 0.01106485 14 23940686 23941158 473 - 2.166 2.077 -0.300
ENSG00000215256 E015 1.5061409 0.010625383 0.168086727 0.28570491 14 23952598 23952985 388 - 0.495 0.254 -1.421
ENSG00000215256 E016 0.7655156 0.172083706 0.966120757 0.98273070 14 23952986 23952989 4 - 0.254 0.253 -0.012
ENSG00000215256 E017 3.7590277 0.004899674 0.087191202 0.17088527 14 23952990 23953308 319 - 0.531 0.791 1.111
ENSG00000215256 E018 4.1307432 0.004754604 0.132280655 0.23728079 14 23953309 23953419 111 - 0.594 0.817 0.927
ENSG00000215256 E019 0.6955713 0.018063048 0.707533348 0.80543420 14 23953420 23953573 154 - 0.185 0.254 0.581
ENSG00000215256 E020 9.0762999 0.006148376 0.946845951 0.97064493 14 23953574 23953773 200 - 1.002 1.006 0.014
ENSG00000215256 E021 65.1177563 0.005544471 0.274248900 0.41337973 14 23953774 23954033 260 - 1.843 1.794 -0.164
ENSG00000215256 E022 18.5498298 0.001026574 0.055744869 0.11925312 14 23954034 23954124 91 - 1.348 1.207 -0.495
ENSG00000215256 E023 11.5350481 0.001514355 0.255680237 0.39259126 14 23954125 23954218 94 - 1.139 1.039 -0.362
ENSG00000215256 E024 0.9534610 0.013718105 0.034631897 0.08095590 14 23954748 23955092 345 - 0.103 0.475 2.898
ENSG00000215256 E025 0.0000000       14 23988729 23990213 1485 -      
ENSG00000215256 E026 0.9482627 0.442348560 0.039243758 0.08963088 14 24044427 24046236 1810 - 0.000 0.484 14.806
ENSG00000215256 E027 0.0000000       14 24052298 24052386 89 -      
ENSG00000215256 E028 0.0000000       14 24052387 24052555 169 -