ENSG00000215252

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342314 ENSG00000215252 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA8B protein_coding protein_coding 7.435167 3.763763 5.384891 0.7083294 0.8222754 0.5155899 1.6355698 2.4789979 0.0000000 0.39492360 0.0000000 -7.9594212 0.26759583 0.66576667 0.00000000 -0.66576667 2.591271e-43 2.591271e-43 FALSE TRUE
ENST00000484716 ENSG00000215252 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA8B protein_coding retained_intron 7.435167 3.763763 5.384891 0.7083294 0.8222754 0.5155899 0.8906621 0.0000000 1.2607133 0.00000000 0.7187468 6.9894948 0.11207500 0.00000000 0.23380000 0.23380000 2.357003e-01 2.591271e-43 FALSE TRUE
ENST00000562282 ENSG00000215252 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA8B protein_coding processed_transcript 7.435167 3.763763 5.384891 0.7083294 0.8222754 0.5155899 0.7378426 0.1447076 0.2999169 0.07629428 0.1882228 1.0023377 0.09851250 0.03386667 0.05023333 0.01636667 9.461061e-01 2.591271e-43   FALSE
ENST00000564575 ENSG00000215252 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA8B protein_coding processed_transcript 7.435167 3.763763 5.384891 0.7083294 0.8222754 0.5155899 0.1468937 0.0000000 0.3518698 0.00000000 0.3518698 5.1773990 0.01420833 0.00000000 0.05023333 0.05023333 8.573226e-01 2.591271e-43   FALSE
ENST00000569100 ENSG00000215252 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA8B protein_coding retained_intron 7.435167 3.763763 5.384891 0.7083294 0.8222754 0.5155899 1.1528603 0.1047797 1.5543392 0.07072345 0.3699926 3.7686134 0.12861667 0.03240000 0.29160000 0.25920000 5.664708e-03 2.591271e-43 FALSE TRUE
ENST00000683415 ENSG00000215252 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLGA8B protein_coding protein_coding 7.435167 3.763763 5.384891 0.7083294 0.8222754 0.5155899 1.9376432 0.9940825 1.9180513 0.31615377 0.2392243 0.9412656 0.26311667 0.25293333 0.37413333 0.12120000 5.039142e-01 2.591271e-43 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000215252 E001 2.2005623 0.0271873149 6.241338e-02 1.307124e-01 15 34525095 34525206 112 - 0.285 0.614 1.745
ENSG00000215252 E002 2.9368325 0.0895089621 2.322331e-01 3.650909e-01 15 34525207 34525281 75 - 0.455 0.683 1.042
ENSG00000215252 E003 46.8687750 0.0090790231 4.552075e-07 4.058435e-06 15 34525282 34525653 372 - 1.464 1.801 1.145
ENSG00000215252 E004 189.9583235 0.0002546806 9.475320e-06 6.333607e-05 15 34525654 34526958 1305 - 2.224 2.312 0.295
ENSG00000215252 E005 80.8681555 0.0016861186 4.220041e-01 5.651631e-01 15 34526959 34527335 377 - 1.920 1.889 -0.104
ENSG00000215252 E006 30.4352686 0.0132912287 8.022255e-01 8.740114e-01 15 34527336 34527495 160 - 1.500 1.483 -0.058
ENSG00000215252 E007 5.6648699 0.0450659187 9.013998e-01 9.411633e-01 15 34527496 34527511 16 - 0.816 0.833 0.066
ENSG00000215252 E008 3.4967844 0.0047192119 6.470406e-01 7.587926e-01 15 34527512 34527527 16 - 0.612 0.679 0.288
ENSG00000215252 E009 2.4325189 0.0064366038 6.451192e-01 7.572988e-01 15 34527528 34527528 1 - 0.500 0.573 0.342
ENSG00000215252 E010 2.4325189 0.0064366038 6.451192e-01 7.572988e-01 15 34527529 34527530 2 - 0.500 0.573 0.342
ENSG00000215252 E011 2.9935135 0.0053125151 4.909608e-01 6.282875e-01 15 34527531 34527573 43 - 0.541 0.646 0.472
ENSG00000215252 E012 1.7766738 0.0450560577 1.836971e-01 3.058384e-01 15 34527574 34527607 34 - 0.285 0.533 1.379
ENSG00000215252 E013 2.6582054 0.0081031751 7.732591e-01 8.536857e-01 15 34527608 34527834 227 - 0.578 0.532 -0.211
ENSG00000215252 E014 0.0000000       15 34527922 34527924 3 -      
ENSG00000215252 E015 0.1451727 0.0428872151 5.389198e-01   15 34527925 34528077 153 - 0.117 0.000 -11.241
ENSG00000215252 E016 0.1451727 0.0428872151 5.389198e-01   15 34528189 34528289 101 - 0.117 0.000 -11.241
ENSG00000215252 E017 0.0000000       15 34528372 34528472 101 -      
ENSG00000215252 E018 0.0000000       15 34528607 34528747 141 -      
ENSG00000215252 E019 0.0000000       15 34528748 34528750 3 -      
ENSG00000215252 E020 0.0000000       15 34529018 34529274 257 -      
ENSG00000215252 E021 0.0000000       15 34529662 34529749 88 -      
ENSG00000215252 E022 0.0000000       15 34529967 34530074 108 -      
ENSG00000215252 E023 0.0000000       15 34530182 34530268 87 -      
ENSG00000215252 E024 0.0000000       15 34531269 34531378 110 -      
ENSG00000215252 E025 0.2944980 0.4050708052 3.312100e-01   15 34531475 34531559 85 - 0.209 0.000 -11.604
ENSG00000215252 E026 0.5975289 0.0233133536 4.804465e-02 1.057133e-01 15 34531648 34531695 48 - 0.350 0.000 -13.154
ENSG00000215252 E027 0.1472490 0.0432528281 5.385202e-01   15 34531961 34531999 39 - 0.117 0.000 -11.240
ENSG00000215252 E028 0.0000000       15 34532846 34532962 117 -      
ENSG00000215252 E029 0.0000000       15 34532963 34533109 147 -      
ENSG00000215252 E030 0.3268771 0.0287370554 9.357281e-01   15 34533110 34533145 36 - 0.117 0.128 0.151
ENSG00000215252 E031 0.0000000       15 34533146 34533185 40 -      
ENSG00000215252 E032 0.3268771 0.0287370554 9.357281e-01   15 34533186 34533346 161 - 0.117 0.128 0.151
ENSG00000215252 E033 0.3268771 0.0287370554 9.357281e-01   15 34533347 34533484 138 - 0.117 0.128 0.151
ENSG00000215252 E034 0.0000000       15 34533485 34534053 569 -      
ENSG00000215252 E035 0.0000000       15 34534054 34534173 120 -      
ENSG00000215252 E036 0.0000000       15 34535865 34535989 125 -      
ENSG00000215252 E037 0.0000000       15 34535990 34536010 21 -      
ENSG00000215252 E038 0.0000000       15 34537344 34537647 304 -      
ENSG00000215252 E039 8.1275378 0.0052033450 1.336724e-03 5.098931e-03 15 34544858 34544953 96 - 1.116 0.737 -1.435
ENSG00000215252 E040 9.3454096 0.0027430638 4.582168e-04 1.999443e-03 15 34545378 34545387 10 - 1.173 0.788 -1.435
ENSG00000215252 E041 9.4969251 0.0026116574 3.127879e-04 1.431757e-03 15 34545388 34545426 39 - 1.182 0.788 -1.467
ENSG00000215252 E042 7.3095959 0.0035529469 8.766093e-04 3.532524e-03 15 34546935 34546982 48 - 1.084 0.679 -1.561
ENSG00000215252 E043 5.6112683 0.0071479998 2.566253e-03 8.961969e-03 15 34551138 34551190 53 - 0.985 0.573 -1.657
ENSG00000215252 E044 3.8720383 0.0863584987 4.884441e-01 6.260078e-01 15 34551191 34551276 86 - 0.750 0.613 -0.579
ENSG00000215252 E045 0.3030308 0.2677502051 2.992703e-01   15 34552268 34552398 131 - 0.210 0.000 -11.741
ENSG00000215252 E046 8.1527063 0.0026288937 7.295961e-03 2.199096e-02 15 34552895 34552972 78 - 1.095 0.788 -1.153
ENSG00000215252 E047 8.1675699 0.0234001574 5.152348e-03 1.634483e-02 15 34552973 34553091 119 - 1.116 0.737 -1.436
ENSG00000215252 E048 8.9981998 0.0560528844 3.703562e-03 1.230755e-02 15 34553745 34553956 212 - 1.184 0.708 -1.797
ENSG00000215252 E049 0.0000000       15 34565890 34566473 584 -      
ENSG00000215252 E050 0.0000000       15 34574825 34574914 90 -      
ENSG00000215252 E051 0.0000000       15 34581466 34581499 34 -      
ENSG00000215252 E052 0.3289534 0.0286479067 9.364082e-01   15 34582750 34582860 111 - 0.117 0.128 0.150
ENSG00000215252 E053 4.9732195 0.0044829522 3.373230e-03 1.135965e-02 15 34583516 34583678 163 - 0.941 0.531 -1.687
ENSG00000215252 E054 0.8136755 0.0144708260 7.437270e-01 8.322926e-01 15 34588391 34588503 113 - 0.285 0.227 -0.435