ENSG00000215126

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000617933 ENSG00000215126 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD6 protein_coding protein_coding 51.74422 57.27308 51.03855 1.50575 1.33216 -0.1662391 40.623197 50.5078942 35.765289 1.2369111 0.8676458 -0.4978311 0.78363750 0.881966667 0.70113333 -0.180833333 8.271568e-18 8.271568e-18 FALSE TRUE
MSTRG.32756.11 ENSG00000215126 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD6 protein_coding   51.74422 57.27308 51.03855 1.50575 1.33216 -0.1662391 4.115197 3.5824763 3.432641 0.2198108 0.6082326 -0.0614629 0.08057500 0.062700000 0.06743333 0.004733333 9.580322e-01 8.271568e-18 FALSE TRUE
MSTRG.32756.13 ENSG00000215126 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD6 protein_coding   51.74422 57.27308 51.03855 1.50575 1.33216 -0.1662391 2.875631 1.3456774 4.817637 0.2972983 0.4979236 1.8323033 0.05578333 0.023300000 0.09420000 0.070900000 8.672287e-07 8.271568e-18 TRUE TRUE
MSTRG.32756.19 ENSG00000215126 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD6 protein_coding   51.74422 57.27308 51.03855 1.50575 1.33216 -0.1662391 1.389716 0.2781182 3.237553 0.1399990 0.3427925 3.4946205 0.02615000 0.004833333 0.06330000 0.058466667 1.277506e-03 8.271568e-18 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000215126 E001 0.0000000       9 41131306 41131308 3 -      
ENSG00000215126 E002 0.0000000       9 41131309 41131324 16 -      
ENSG00000215126 E003 0.0000000       9 41131325 41131355 31 -      
ENSG00000215126 E004 0.0000000       9 41131356 41131357 2 -      
ENSG00000215126 E005 0.5244761 0.2040635835 1.0000000000 1.0000000000 9 41131358 41131675 318 - 0.176 0.156 -0.212
ENSG00000215126 E006 0.5244761 0.2040635835 1.0000000000 1.0000000000 9 41131676 41131676 1 - 0.176 0.156 -0.212
ENSG00000215126 E007 0.5244761 0.2040635835 1.0000000000 1.0000000000 9 41131677 41131677 1 - 0.176 0.156 -0.212
ENSG00000215126 E008 0.5244761 0.2040635835 1.0000000000 1.0000000000 9 41131678 41131678 1 - 0.176 0.156 -0.212
ENSG00000215126 E009 1.1845598 0.0187789591 0.7516651482 0.8380505260 9 41131679 41131688 10 - 0.300 0.357 0.359
ENSG00000215126 E010 1.7025914 0.0177008890 0.1523880357 0.2649254298 9 41131689 41131702 14 - 0.300 0.551 1.357
ENSG00000215126 E011 19.5963142 0.0123181112 0.6683773847 0.7754050288 9 41131703 41131840 138 - 1.294 1.329 0.123
ENSG00000215126 E012 0.9578041 0.0124584007 0.2807795792 0.4206531886 9 41131841 41132227 387 - 0.351 0.154 -1.549
ENSG00000215126 E013 35.7045565 0.0007716174 0.3238368668 0.4671752644 9 41132228 41132357 130 - 1.533 1.589 0.192
ENSG00000215126 E014 4.4596981 0.0038119359 0.1679030536 0.2854669856 9 41132358 41133504 1147 - 0.652 0.842 0.770
ENSG00000215126 E015 30.2415156 0.0008257719 0.0613125421 0.1288429659 9 41133505 41133570 66 - 1.434 1.550 0.397
ENSG00000215126 E016 46.7697443 0.0007881978 0.7042318751 0.8028166515 9 41133674 41133742 69 - 1.664 1.683 0.066
ENSG00000215126 E017 1.1113933 0.0973745867 0.1774569227 0.2979481508 9 41133743 41134034 292 - 0.176 0.435 1.791
ENSG00000215126 E018 1.7862559 0.0083761356 0.1248090594 0.2268555655 9 41142246 41142290 45 - 0.543 0.267 -1.552
ENSG00000215126 E019 0.0000000       9 41142291 41142291 1 -      
ENSG00000215126 E020 38.5546361 0.0022359940 0.4753053988 0.6140183832 9 41145281 41145317 37 - 1.573 1.613 0.136
ENSG00000215126 E021 26.6077318 0.0008163948 0.9144543272 0.9498554227 9 41145318 41145332 15 - 1.430 1.437 0.025
ENSG00000215126 E022 1.0234925 0.0432666340 0.1527879150 0.2654501214 9 41145333 41145992 660 - 0.175 0.432 1.775
ENSG00000215126 E023 18.4084882 0.0009825427 0.0594456370 0.1256897053 9 41156383 41156394 12 - 1.341 1.189 -0.534
ENSG00000215126 E024 21.8718770 0.0009192022 0.0795310069 0.1587958660 9 41156395 41156439 45 - 1.405 1.275 -0.451
ENSG00000215126 E025 2.2915875 0.0082412627 0.6596337993 0.7684140762 9 41156440 41157201 762 - 0.476 0.550 0.357
ENSG00000215126 E026 0.7416694 0.0176198137 0.4185731775 0.5618273282 9 41157202 41157338 137 - 0.300 0.154 -1.230
ENSG00000215126 E027 2.3689213 0.0074916832 0.3079366671 0.4501746119 9 41157339 41157458 120 - 0.601 0.431 -0.816
ENSG00000215126 E028 1.2522004 0.1779561920 0.9640441376 0.9813296960 9 41157459 41158122 664 - 0.351 0.355 0.027
ENSG00000215126 E029 1.2877991 0.0112031431 0.0082724780 0.0244732910 9 41158123 41158329 207 - 0.097 0.551 3.358
ENSG00000215126 E030 1.7132031 0.0169593181 0.5056979580 0.6414317348 9 41158330 41158916 587 - 0.476 0.357 -0.645
ENSG00000215126 E031 0.0000000       9 41160764 41160804 41 -      
ENSG00000215126 E032 0.2924217 0.0278502833 0.3955601300   9 41160805 41160937 133 - 0.176 0.000 -10.902
ENSG00000215126 E033 1.3662642 0.0109705429 0.4560228136 0.5964949560 9 41160938 41161021 84 - 0.300 0.432 0.773
ENSG00000215126 E034 0.1817044 0.0456586002 0.2869666553   9 41161427 41161468 42 - 0.000 0.154 10.343
ENSG00000215126 E035 4.7553446 0.0045418527 0.5826362775 0.7069575414 9 41161601 41161723 123 - 0.794 0.720 -0.300
ENSG00000215126 E036 19.8015036 0.0009886919 0.3884612781 0.5325365521 9 41162333 41162377 45 - 1.341 1.275 -0.229
ENSG00000215126 E037 2.8689794 0.0563656885 0.0812682867 0.1615346928 9 41164133 41165000 868 - 0.438 0.750 1.409
ENSG00000215126 E038 21.9762480 0.0008700674 0.3008973064 0.4426745877 9 41165001 41165023 23 - 1.388 1.313 -0.260
ENSG00000215126 E039 25.5901110 0.0012993618 0.0970203804 0.1859216305 9 41165024 41165087 64 - 1.468 1.355 -0.390
ENSG00000215126 E040 18.3996766 0.0015500712 0.5551468900 0.6840295598 9 41166784 41166830 47 - 1.310 1.265 -0.158
ENSG00000215126 E041 0.4418608 0.0284035955 0.2080271369 0.3361211268 9 41170279 41170283 5 - 0.242 0.000 -11.411
ENSG00000215126 E042 1.1019577 0.2918081324 0.7557470316 0.8409979141 9 41170284 41170423 140 - 0.351 0.268 -0.541
ENSG00000215126 E043 7.1695459 0.0028509714 0.1791254059 0.3000474877 9 41171847 41171919 73 - 0.976 0.814 -0.617
ENSG00000215126 E044 2.2069977 0.0310665030 0.2368990300 0.3705859423 9 41171920 41171934 15 - 0.573 0.358 -1.098
ENSG00000215126 E045 5.6147129 0.1093826809 0.5075704220 0.6430420416 9 41172712 41172749 38 - 0.872 0.721 -0.598
ENSG00000215126 E046 0.0000000       9 41174293 41174352 60 -      
ENSG00000215126 E047 0.0000000       9 41176298 41177919 1622 -      
ENSG00000215126 E048 5.2512275 0.0863770345 0.8859209828 0.9310409467 9 41182375 41182466 92 - 0.810 0.780 -0.119
ENSG00000215126 E049 3.6772662 0.0045481159 0.0001390788 0.0006995368 9 41183564 41183660 97 - 0.351 0.915 2.536
ENSG00000215126 E050 3.0194492 0.0054692109 0.0402926266 0.0915759764 9 41185993 41186079 87 - 0.438 0.754 1.424
ENSG00000215126 E051 0.0000000       9 41188010 41188107 98 -      
ENSG00000215126 E052 2.1756864 0.0075823531 0.4987700722 0.6351704301 9 41189105 41189436 332 - 0.438 0.551 0.550
ENSG00000215126 E053 0.0000000       9 41196167 41196295 129 -      
ENSG00000215126 E054 0.0000000       9 41198807 41198865 59 -      
ENSG00000215126 E055 0.0000000       9 41199104 41199261 158 -