ENSG00000215114

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399598 ENSG00000215114 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN2B protein_coding protein_coding 10.59187 5.805219 15.62816 0.05636101 0.9644463 1.427165 6.9601227 3.92353140 10.5057066 0.25023803 0.8147396 1.418649 0.64996667 0.675266667 0.67113333 -0.004133333 0.9708656641 0.0001505453 FALSE TRUE
ENST00000521796 ENSG00000215114 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN2B protein_coding protein_coding 10.59187 5.805219 15.62816 0.05636101 0.9644463 1.427165 0.9767386 1.41314726 0.5540358 0.14222775 0.2404542 -1.335226 0.12719583 0.243733333 0.03760000 -0.206133333 0.0024589632 0.0001505453 FALSE FALSE
ENST00000522978 ENSG00000215114 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN2B protein_coding processed_transcript 10.59187 5.805219 15.62816 0.05636101 0.9644463 1.427165 0.6309071 0.00000000 2.2349991 0.00000000 1.2158106 7.810571 0.03896667 0.000000000 0.13466667 0.134666667 0.2761018986 0.0001505453   FALSE
ENST00000523409 ENSG00000215114 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN2B protein_coding nonsense_mediated_decay 10.59187 5.805219 15.62816 0.05636101 0.9644463 1.427165 0.6766858 0.04061217 1.1636121 0.04061217 0.1766726 4.535328 0.05772083 0.007133333 0.07493333 0.067800000 0.0001505453 0.0001505453 TRUE TRUE
MSTRG.31539.1 ENSG00000215114 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN2B protein_coding   10.59187 5.805219 15.62816 0.05636101 0.9644463 1.427165 1.0406464 0.31884062 1.0484381 0.18729546 0.8264068 1.686477 0.09855000 0.055366667 0.07356667 0.018200000 0.9860822272 0.0001505453 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000215114 E001 0.5159433 0.2843055011 7.998178e-01 8.723371e-01 8 58411330 58411357 28 + 0.139 0.196 0.598
ENSG00000215114 E002 0.5159433 0.2843055011 7.998178e-01 8.723371e-01 8 58411358 58411358 1 + 0.139 0.196 0.598
ENSG00000215114 E003 0.6674587 0.0306313779 9.238214e-01 9.560302e-01 8 58411359 58411360 2 + 0.195 0.194 -0.013
ENSG00000215114 E004 8.4470109 0.0306482240 4.962872e-01 6.329831e-01 8 58411361 58411380 20 + 0.881 1.027 0.544
ENSG00000215114 E005 32.3717406 0.0073951014 7.707342e-01 8.519855e-01 8 58411381 58411469 89 + 1.470 1.504 0.117
ENSG00000215114 E006 8.7071619 0.0056625822 6.022700e-03 1.867188e-02 8 58413299 58413371 73 + 1.019 0.693 -1.266
ENSG00000215114 E007 54.9620277 0.0004785135 5.282700e-02 1.141803e-01 8 58416850 58416929 80 + 1.716 1.672 -0.149
ENSG00000215114 E008 47.4948063 0.0004993592 8.214347e-03 2.432857e-02 8 58416930 58416953 24 + 1.668 1.573 -0.321
ENSG00000215114 E009 86.5712493 0.0006954984 1.339086e-01 2.395801e-01 8 58430519 58430669 151 + 1.900 1.894 -0.018
ENSG00000215114 E010 66.4579857 0.0005461352 7.521959e-01 8.384745e-01 8 58433160 58433243 84 + 1.765 1.838 0.245
ENSG00000215114 E011 77.7781923 0.0003861359 3.408721e-01 4.848029e-01 8 58434395 58434504 110 + 1.848 1.865 0.057
ENSG00000215114 E012 12.0014460 0.0015462996 6.592392e-02 1.365779e-01 8 58434858 58434948 91 + 0.986 1.223 0.854
ENSG00000215114 E013 6.1289005 0.0036307890 2.042626e-06 1.585875e-05 8 58434949 58435106 158 + 0.514 1.160 2.570
ENSG00000215114 E014 75.2377976 0.0026787040 6.092138e-05 3.360031e-04 8 58439633 58439770 138 + 1.878 1.726 -0.513
ENSG00000215114 E015 73.7239757 0.0032174940 1.927439e-04 9.327839e-04 8 58445907 58446068 162 + 1.866 1.722 -0.485
ENSG00000215114 E016 866.9484189 0.0096232506 2.389830e-02 5.959618e-02 8 58447389 58451501 4113 + 2.864 2.967 0.343