ENSG00000214941

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000472495 ENSG00000214941 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSWIM7 protein_coding protein_coding 24.25031 34.01594 23.64261 2.580638 0.6658669 -0.5246356 5.9848831 9.542253 3.255768 2.0339822 1.8251232 -1.54841882 0.24022917 0.27720000 0.1335333 -0.14366667 6.569960e-01 4.405949e-21 FALSE  
ENST00000476496 ENSG00000214941 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSWIM7 protein_coding nonsense_mediated_decay 24.25031 34.01594 23.64261 2.580638 0.6658669 -0.5246356 1.4915599 1.127429 1.387195 0.5704038 0.3908698 0.29675699 0.05899167 0.03143333 0.0597000 0.02826667 6.911297e-01 4.405949e-21    
ENST00000486706 ENSG00000214941 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSWIM7 protein_coding nonsense_mediated_decay 24.25031 34.01594 23.64261 2.580638 0.6658669 -0.5246356 0.7561195 2.213392 0.000000 0.2108039 0.0000000 -7.79661880 0.02612083 0.06560000 0.0000000 -0.06560000 4.405949e-21 4.405949e-21    
ENST00000491631 ENSG00000214941 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSWIM7 protein_coding nonsense_mediated_decay 24.25031 34.01594 23.64261 2.580638 0.6658669 -0.5246356 4.8858658 7.492492 4.003010 1.0300378 0.1337176 -0.90268510 0.20075833 0.21853333 0.1693000 -0.04923333 1.801939e-01 4.405949e-21    
MSTRG.13730.11 ENSG00000214941 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSWIM7 protein_coding   24.25031 34.01594 23.64261 2.580638 0.6658669 -0.5246356 0.8988410 0.000000 1.542619 0.0000000 0.2686135 7.27855987 0.04057083 0.00000000 0.0659000 0.06590000 7.012966e-15 4.405949e-21 TRUE  
MSTRG.13730.8 ENSG00000214941 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSWIM7 protein_coding   24.25031 34.01594 23.64261 2.580638 0.6658669 -0.5246356 2.8046875 4.758126 4.964874 1.2693599 1.0215299 0.06123751 0.11396667 0.14576667 0.2085000 0.06273333 5.832527e-01 4.405949e-21 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000214941 E001 0.0000000       17 15976532 15976559 28 -      
ENSG00000214941 E002 0.2966881 0.0293842455 1.015444e-01   17 15976560 15976568 9 - 0.265 0.000 -11.195
ENSG00000214941 E003 37.8977946 0.0053728176 4.306253e-02 9.666299e-02 17 15976569 15976715 147 - 1.663 1.524 -0.473
ENSG00000214941 E004 34.0979794 0.0115981960 1.023611e-01 1.941220e-01 17 15976716 15976731 16 - 1.612 1.483 -0.442
ENSG00000214941 E005 30.7430302 0.0141249356 2.081210e-01 3.362148e-01 17 15976732 15976741 10 - 1.555 1.449 -0.365
ENSG00000214941 E006 54.5067547 0.0010831172 6.605912e-02 1.368101e-01 17 15976742 15976804 63 - 1.792 1.692 -0.338
ENSG00000214941 E007 120.3154121 0.0041116171 4.078301e-06 2.959557e-05 17 15976805 15977011 207 - 2.189 1.976 -0.712
ENSG00000214941 E008 77.9090565 0.0072140070 5.824633e-07 5.089440e-06 17 15977012 15977092 81 - 2.044 1.747 -1.002
ENSG00000214941 E009 27.2313526 0.0325360548 1.271601e-03 4.882368e-03 17 15977093 15977578 486 - 1.630 1.260 -1.278
ENSG00000214941 E010 19.9198559 0.0013085839 1.743247e-02 4.589588e-02 17 15977579 15977682 104 - 1.419 1.227 -0.670
ENSG00000214941 E011 9.7895755 0.0154733298 1.823123e-01 3.041139e-01 17 15977683 15977700 18 - 1.120 0.965 -0.568
ENSG00000214941 E012 5.2387398 0.0088865381 8.790558e-01 9.263238e-01 17 15977701 15977726 26 - 0.781 0.797 0.061
ENSG00000214941 E013 4.1682188 0.0048969871 7.330673e-01 8.243788e-01 17 15977727 15977729 3 - 0.680 0.722 0.175
ENSG00000214941 E014 6.8348698 0.0234152500 5.751480e-01 7.008385e-01 17 15977730 15977732 3 - 0.933 0.859 -0.283
ENSG00000214941 E015 46.3915824 0.0009538647 7.463516e-04 3.065388e-03 17 15977733 15977799 67 - 1.534 1.714 0.611
ENSG00000214941 E016 102.7112985 0.0050772327 5.214293e-03 1.651368e-02 17 15977800 15977890 91 - 1.906 2.037 0.440
ENSG00000214941 E017 91.1202044 0.0003615429 2.231539e-05 1.368283e-04 17 15977891 15977913 23 - 1.837 1.994 0.527
ENSG00000214941 E018 41.8677827 0.0007794160 1.304635e-03 4.992508e-03 17 15977914 15977924 11 - 1.489 1.668 0.608
ENSG00000214941 E019 55.3713424 0.0008910995 5.836364e-03 1.818107e-02 17 15977925 15977962 38 - 1.642 1.773 0.443
ENSG00000214941 E020 84.0706462 0.0005438799 4.990409e-03 1.590247e-02 17 15977963 15978043 81 - 1.840 1.944 0.352
ENSG00000214941 E021 157.0129400 0.0002488648 5.423584e-01 6.731279e-01 17 15978044 15978077 34 - 2.174 2.181 0.022
ENSG00000214941 E022 188.0368734 0.0003139544 1.195586e-01 2.193281e-01 17 15978078 15978163 86 - 2.235 2.265 0.099
ENSG00000214941 E023 7.6817068 0.0197835469 8.785285e-02 1.718549e-01 17 15980243 15980367 125 - 1.061 0.831 -0.863
ENSG00000214941 E024 200.3314673 0.0002317125 9.234491e-02 1.787828e-01 17 15981040 15981144 105 - 2.264 2.295 0.106
ENSG00000214941 E025 16.1735547 0.0088297551 4.712810e-01 6.104178e-01 17 15986800 15986886 87 - 1.173 1.232 0.211
ENSG00000214941 E026 9.6039259 0.0026864790 4.693153e-01 6.085792e-01 17 15986887 15986892 6 - 0.954 1.024 0.260
ENSG00000214941 E027 198.9913280 0.0019333279 4.777641e-01 6.162665e-01 17 15987266 15987368 103 - 2.273 2.280 0.021
ENSG00000214941 E028 3.1492964 0.0406493694 1.332534e-01 2.386506e-01 17 15990865 15991104 240 - 0.751 0.481 -1.193
ENSG00000214941 E029 103.5902171 0.0031349851 8.290396e-01 8.926245e-01 17 15993757 15993778 22 - 1.999 1.992 -0.025
ENSG00000214941 E030 1.4674297 0.0102671159 2.973039e-01 4.386245e-01 17 15993779 15993830 52 - 0.492 0.303 -1.061
ENSG00000214941 E031 2.3907003 0.0241370936 8.444977e-01 9.031995e-01 17 15999503 15999505 3 - 0.492 0.515 0.111
ENSG00000214941 E032 22.7460333 0.0440123417 4.244730e-01 5.674405e-01 17 15999506 15999518 13 - 1.290 1.370 0.279
ENSG00000214941 E033 129.0848685 0.0095769860 9.699754e-01 9.852118e-01 17 15999519 15999659 141 - 2.103 2.081 -0.074
ENSG00000214941 E034 26.6838377 0.0216129503 9.003795e-01 9.404400e-01 17 15999660 15999717 58 - 1.425 1.411 -0.049