ENSG00000214439

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000643546 ENSG00000214439 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 1.752559 1.109286 1.997045 0.2752552 0.3107838 0.8424947 0.1164714 0.06021233 0.1063564 0.06021233 0.106356408 0.7287544 0.0729000 0.0869000 0.0436000 -0.04330000 9.510632e-01 2.818976e-08 TRUE TRUE
ENST00000684844 ENSG00000214439 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 1.752559 1.109286 1.997045 0.2752552 0.3107838 0.8424947 0.4301477 0.37982211 0.2465920 0.07392909 0.058388252 -0.6033400 0.2502417 0.3554000 0.1348333 -0.22056667 4.333334e-02 2.818976e-08 FALSE TRUE
ENST00000689804 ENSG00000214439 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 1.752559 1.109286 1.997045 0.2752552 0.3107838 0.8424947 0.2883128 0.23058587 0.0000000 0.23058587 0.000000000 -4.5884800 0.1555958 0.2292667 0.0000000 -0.22926667 7.364990e-01 2.818976e-08 FALSE TRUE
ENST00000692528 ENSG00000214439 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 1.752559 1.109286 1.997045 0.2752552 0.3107838 0.8424947 0.3890985 0.29518347 0.4781509 0.23318286 0.251114260 0.6776503 0.2464417 0.2171667 0.2065667 -0.01060000 1.000000e+00 2.818976e-08 FALSE TRUE
MSTRG.30122.1 ENSG00000214439 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   1.752559 1.109286 1.997045 0.2752552 0.3107838 0.8424947 0.2045769 0.14348196 0.3477320 0.10434250 0.009462837 1.2208100 0.1021042 0.1112667 0.1860333 0.07476667 6.881253e-01 2.818976e-08 FALSE TRUE
MSTRG.30122.5 ENSG00000214439 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   1.752559 1.109286 1.997045 0.2752552 0.3107838 0.8424947 0.2651169 0.00000000 0.8182139 0.00000000 0.040129852 6.3719315 0.1435125 0.0000000 0.4289333 0.42893333 2.818976e-08 2.818976e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000214439 E001 0.5879639 0.022594391 0.754858473 0.84036453 7 77063187 77063237 51 - 0.222 0.169 -0.496
ENSG00000214439 E002 1.1395059 0.013317358 0.010244191 0.02936663 7 77083681 77083786 106 - 0.087 0.529 3.415
ENSG00000214439 E003 1.5113206 0.010767337 0.001173172 0.00455028 7 77083787 77083885 99 - 0.087 0.637 3.900
ENSG00000214439 E004 0.6652806 0.018922637 0.083192513 0.16457034 7 77083886 77083886 1 - 0.087 0.384 2.674
ENSG00000214439 E005 2.1785929 0.186648481 0.179534733 0.30056040 7 77083887 77084021 135 - 0.369 0.670 1.458
ENSG00000214439 E006 1.1039323 0.014723692 0.178768131 0.29960532 7 77094002 77094097 96 - 0.222 0.462 1.503
ENSG00000214439 E007 0.6568746 0.092629545 0.095491111 0.18362080 7 77098910 77098951 42 - 0.087 0.384 2.672
ENSG00000214439 E008 0.4762024 0.240645141 0.926798307 0.95792087 7 77109526 77109544 19 - 0.160 0.169 0.095
ENSG00000214439 E009 2.0972239 0.011059327 0.640915618 0.75405073 7 77109545 77109662 118 - 0.445 0.528 0.413
ENSG00000214439 E010 5.0871696 0.004276914 0.346362450 0.49050149 7 77109938 77110076 139 - 0.803 0.681 -0.494
ENSG00000214439 E011 4.2377659 0.120882889 0.414768277 0.55815970 7 77113391 77113483 93 - 0.756 0.587 -0.716
ENSG00000214439 E012 7.4100709 0.002706566 0.008121878 0.02409247 7 77119517 77119626 110 - 0.997 0.681 -1.232
ENSG00000214439 E013 0.2987644 0.029078516 0.487787771   7 77121583 77121589 7 - 0.160 0.000 -9.779
ENSG00000214439 E014 0.2987644 0.029078516 0.487787771   7 77121590 77121665 76 - 0.160 0.000 -9.779
ENSG00000214439 E015 5.5110292 0.003615506 0.378003551 0.52230476 7 77121666 77121906 241 - 0.737 0.856 0.470
ENSG00000214439 E016 7.9961950 0.005788077 0.294659902 0.43577232 7 77121907 77122097 191 - 0.966 0.856 -0.417
ENSG00000214439 E017 4.8908026 0.016174568 0.493498301 0.63051682 7 77122098 77122332 235 - 0.772 0.683 -0.363