ENSG00000214087

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000622299 ENSG00000214087 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL16 protein_coding protein_coding 66.43738 111.7224 48.45627 6.217409 1.706215 -1.204995 45.41072 78.60910 30.829727 5.043516 1.1123114 -1.350090 0.6733958 0.7029000 0.6362667 -0.06663333 0.002495403 3.447679e-09 FALSE  
MSTRG.15298.6 ENSG00000214087 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL16 protein_coding   66.43738 111.7224 48.45627 6.217409 1.706215 -1.204995 10.41152 17.33054 8.356419 1.162495 0.5010687 -1.051467 0.1565083 0.1549333 0.1724667 0.01753333 0.529925667 3.447679e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000214087 E001 19.92719 0.0231671764 1.144087e-01 2.119745e-01 17 81681187 81681200 14 - 1.107 1.297 0.675
ENSG00000214087 E002 25.48324 0.0056075134 3.900474e-03 1.286443e-02 17 81681201 81681219 19 - 1.142 1.413 0.953
ENSG00000214087 E003 25.33495 0.0043408886 3.555500e-03 1.188473e-02 17 81681220 81681221 2 - 1.142 1.411 0.944
ENSG00000214087 E004 318.99320 0.0011395859 3.410972e-06 2.522439e-05 17 81681222 81681368 147 - 2.333 2.466 0.441
ENSG00000214087 E005 450.03491 0.0003862100 4.022401e-05 2.317192e-04 17 81681369 81681465 97 - 2.520 2.605 0.285
ENSG00000214087 E006 353.19978 0.0004912809 1.383429e-04 6.962976e-04 17 81681466 81681491 26 - 2.410 2.500 0.300
ENSG00000214087 E007 378.42836 0.0001378642 1.058510e-06 8.738135e-06 17 81681492 81681522 31 - 2.428 2.534 0.351
ENSG00000214087 E008 588.37804 0.0001350443 1.965742e-02 5.075484e-02 17 81681523 81681607 85 - 2.672 2.711 0.130
ENSG00000214087 E009 909.86066 0.0002654971 1.503171e-01 2.621119e-01 17 81681608 81681794 187 - 2.876 2.896 0.066
ENSG00000214087 E010 638.54113 0.0001366923 1.292713e-01 2.331699e-01 17 81681795 81681879 85 - 2.756 2.732 -0.081
ENSG00000214087 E011 642.86694 0.0003754339 1.160089e-01 2.142561e-01 17 81682034 81682149 116 - 2.761 2.732 -0.094
ENSG00000214087 E012 49.16460 0.0065650419 3.908373e-06 2.848463e-05 17 81682150 81682442 293 - 1.836 1.535 -1.020
ENSG00000214087 E013 30.26831 0.0007098191 6.659248e-05 3.636395e-04 17 81682443 81682490 48 - 1.609 1.345 -0.909
ENSG00000214087 E014 71.60395 0.0063558258 1.421858e-02 3.872159e-02 17 81682491 81682664 174 - 1.896 1.747 -0.505
ENSG00000214087 E015 40.64442 0.0062100249 8.724375e-02 1.709608e-01 17 81682665 81682675 11 - 1.637 1.512 -0.426
ENSG00000214087 E016 15.19499 0.0085142838 2.252678e-05 1.380224e-04 17 81682676 81682684 9 - 1.409 0.997 -1.467
ENSG00000214087 E017 40.69538 0.0168071276 3.073319e-05 1.824146e-04 17 81682685 81683012 328 - 1.790 1.433 -1.216
ENSG00000214087 E018 526.78992 0.0001592380 2.027951e-02 5.207117e-02 17 81683013 81683126 114 - 2.684 2.643 -0.138
ENSG00000214087 E019 25.57453 0.0052776533 8.471311e-09 1.058059e-07 17 81683127 81683535 409 - 1.642 1.200 -1.530
ENSG00000214087 E020 412.69312 0.0004744203 1.826154e-02 4.770210e-02 17 81683536 81683592 57 - 2.587 2.534 -0.174
ENSG00000214087 E021 316.09145 0.0003062528 4.157536e-03 1.358456e-02 17 81683593 81683594 2 - 2.482 2.415 -0.224
ENSG00000214087 E022 27.04624 0.0035797606 5.954682e-01 7.175594e-01 17 81683595 81683692 98 - 1.409 1.364 -0.155
ENSG00000214087 E023 302.36019 0.0001806433 6.345517e-03 1.952205e-02 17 81683693 81683819 127 - 2.460 2.397 -0.210