ENSG00000214063

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397397 ENSG00000214063 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN4 protein_coding protein_coding 38.86679 69.28133 18.40372 3.900953 0.8540043 -1.911894 10.545148 18.239565 5.538425 3.200676 0.4015383 -1.717712 0.26959583 0.26130000 0.3004667 0.03916667 7.200386e-01 2.339534e-09 FALSE TRUE
ENST00000397411 ENSG00000214063 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN4 protein_coding protein_coding 38.86679 69.28133 18.40372 3.900953 0.8540043 -1.911894 1.265472 4.037331 0.000000 1.418489 0.0000000 -8.660827 0.02427083 0.05633333 0.0000000 -0.05633333 9.508347e-07 2.339534e-09 FALSE TRUE
ENST00000409543 ENSG00000214063 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN4 protein_coding protein_coding 38.86679 69.28133 18.40372 3.900953 0.8540043 -1.911894 5.872405 15.562301 0.000000 5.136929 0.0000000 -10.604766 0.14001667 0.23076667 0.0000000 -0.23076667 2.339534e-09 2.339534e-09 FALSE TRUE
ENST00000527644 ENSG00000214063 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN4 protein_coding protein_coding 38.86679 69.28133 18.40372 3.900953 0.8540043 -1.911894 14.795405 22.867378 8.950763 3.180870 0.3757110 -1.352228 0.38136250 0.32770000 0.4895667 0.16186667 6.034885e-02 2.339534e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000214063 E001 0.1482932 0.0415071221 1.000000e+00   11 842812 842823 12 + 0.000 0.064 7.192
ENSG00000214063 E002 0.6652806 0.0191372283 7.886432e-01 8.646974e-01 11 842824 842830 7 + 0.221 0.170 -0.472
ENSG00000214063 E003 3.0141360 0.0054987092 7.038155e-01 8.024461e-01 11 842831 842851 21 + 0.563 0.488 -0.354
ENSG00000214063 E004 21.2905865 0.0068808439 7.591214e-01 8.435350e-01 11 842852 842915 64 + 1.245 1.207 -0.133
ENSG00000214063 E005 0.6998377 0.0174361267 1.794526e-01 3.004467e-01 11 842916 842940 25 + 0.367 0.120 -2.054
ENSG00000214063 E006 4.5631645 0.0043630820 1.378172e-02 3.772876e-02 11 842941 843045 105 + 0.919 0.551 -1.515
ENSG00000214063 E007 1.2189014 0.0116386096 1.686704e-01 2.864426e-01 11 843046 843050 5 + 0.476 0.215 -1.640
ENSG00000214063 E008 0.5985731 0.0228105685 1.848925e-02 4.820784e-02 11 843315 843338 24 + 0.476 0.064 -3.644
ENSG00000214063 E009 1.6650287 0.0084172918 5.822433e-03 1.814334e-02 11 843339 843669 331 + 0.697 0.215 -2.640
ENSG00000214063 E010 0.0000000       11 843670 843729 60 +      
ENSG00000214063 E011 0.7696683 0.0161922213 5.115438e-02 1.112175e-01 11 844081 844116 36 + 0.476 0.120 -2.642
ENSG00000214063 E012 0.6224193 0.0180986166 1.793202e-01 3.002544e-01 11 844117 844152 36 + 0.367 0.120 -2.057
ENSG00000214063 E013 0.6224193 0.0180986166 1.793202e-01 3.002544e-01 11 844153 844186 34 + 0.367 0.120 -2.057
ENSG00000214063 E014 0.2903454 0.3132860836 4.079550e-02   11 844446 844587 142 + 0.366 0.000 -12.239
ENSG00000214063 E015 0.0000000       11 847170 847196 27 +      
ENSG00000214063 E016 0.0000000       11 847197 847200 4 +      
ENSG00000214063 E017 46.9224640 0.0017357493 6.800781e-03 2.070464e-02 11 847201 847300 100 + 1.694 1.516 -0.607
ENSG00000214063 E018 0.4427912 0.1397001479 9.793006e-02 1.873636e-01 11 848810 848933 124 + 0.367 0.064 -3.067
ENSG00000214063 E019 11.0245458 0.0526064402 3.285551e-04 1.495059e-03 11 849816 849871 56 + 1.335 0.816 -1.895
ENSG00000214063 E020 194.2898780 0.0063471425 4.185104e-04 1.845352e-03 11 849872 850287 416 + 2.297 2.127 -0.568
ENSG00000214063 E021 262.6124342 0.0045369973 2.474142e-01 3.829057e-01 11 850288 850367 80 + 2.337 2.283 -0.181
ENSG00000214063 E022 0.8481309 0.0143105062 3.020647e-01 4.438991e-01 11 862297 862329 33 + 0.367 0.170 -1.471
ENSG00000214063 E023 3.5018795 0.0172177905 1.600342e-01 2.751504e-01 11 862345 862549 205 + 0.752 0.509 -1.058
ENSG00000214063 E024 532.9133040 0.0001856332 5.115190e-01 6.465227e-01 11 862550 862741 192 + 2.613 2.592 -0.070
ENSG00000214063 E025 4.9726568 0.0153161240 3.197351e-02 7.580989e-02 11 862742 863271 530 + 0.919 0.589 -1.341
ENSG00000214063 E026 11.4540738 0.0178247805 1.553445e-06 1.237316e-05 11 863272 864352 1081 + 1.373 0.811 -2.045
ENSG00000214063 E027 2.2561105 0.0073535649 3.490974e-01 4.933310e-01 11 864353 864436 84 + 0.563 0.387 -0.886
ENSG00000214063 E028 413.7203529 0.0012507451 9.210048e-01 9.541396e-01 11 864437 864511 75 + 2.492 2.484 -0.027
ENSG00000214063 E029 10.8415217 0.0320724295 1.265518e-01 2.293465e-01 11 864512 865512 1001 + 1.112 0.902 -0.773
ENSG00000214063 E030 491.1457877 0.0001264778 4.139837e-01 5.574048e-01 11 865513 865614 102 + 2.553 2.561 0.025
ENSG00000214063 E031 11.4567035 0.0166219308 5.123683e-01 6.472749e-01 11 865615 865693 79 + 1.040 0.950 -0.333
ENSG00000214063 E032 545.4009009 0.0001330379 6.741929e-03 2.055321e-02 11 865694 865825 132 + 2.568 2.612 0.144
ENSG00000214063 E033 477.4340050 0.0002421423 8.715487e-04 3.514673e-03 11 865918 866001 84 + 2.495 2.558 0.209
ENSG00000214063 E034 12.7781603 0.0220400715 2.551092e-03 8.915432e-03 11 866002 866561 560 + 1.292 0.925 -1.325
ENSG00000214063 E035 637.6379320 0.0005060894 1.479183e-04 7.380612e-04 11 866562 867116 555 + 2.618 2.685 0.222