ENSG00000213918

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000407479 ENSG00000213918 HEK293_OSMI2_2hA HEK293_TMG_2hB DNASE1 protein_coding protein_coding 7.257599 7.541925 4.671123 0.3644327 0.2060865 -0.6899896 0.7836902 0.7671637 0.4728129 0.03593554 0.03591440 -0.6867543 0.11055833 0.10203333 0.10090000 -0.001133333 0.99564858 0.01373985 FALSE TRUE
ENST00000570376 ENSG00000213918 HEK293_OSMI2_2hA HEK293_TMG_2hB DNASE1 protein_coding nonsense_mediated_decay 7.257599 7.541925 4.671123 0.3644327 0.2060865 -0.6899896 0.8202127 0.5101848 0.4004302 0.51018476 0.22418740 -0.3418872 0.10494583 0.06870000 0.08983333 0.021133333 0.62364046 0.01373985 FALSE FALSE
ENST00000570761 ENSG00000213918 HEK293_OSMI2_2hA HEK293_TMG_2hB DNASE1 protein_coding processed_transcript 7.257599 7.541925 4.671123 0.3644327 0.2060865 -0.6899896 1.3789214 1.0353346 1.1511054 0.16804427 0.21976627 0.1515342 0.19596250 0.13583333 0.24343333 0.107600000 0.14589309 0.01373985 FALSE TRUE
ENST00000571460 ENSG00000213918 HEK293_OSMI2_2hA HEK293_TMG_2hB DNASE1 protein_coding nonsense_mediated_decay 7.257599 7.541925 4.671123 0.3644327 0.2060865 -0.6899896 0.8378593 1.3884328 0.3056126 0.28424864 0.02464208 -2.1475840 0.10332500 0.18293333 0.06566667 -0.117266667 0.01373985 0.01373985 FALSE TRUE
MSTRG.11947.10 ENSG00000213918 HEK293_OSMI2_2hA HEK293_TMG_2hB DNASE1 protein_coding   7.257599 7.541925 4.671123 0.3644327 0.2060865 -0.6899896 1.0650583 1.3415429 0.6558101 0.05136053 0.10295754 -1.0214245 0.14864167 0.17810000 0.14006667 -0.038033333 0.56047170 0.01373985 TRUE FALSE
MSTRG.11947.12 ENSG00000213918 HEK293_OSMI2_2hA HEK293_TMG_2hB DNASE1 protein_coding   7.257599 7.541925 4.671123 0.3644327 0.2060865 -0.6899896 0.3423439 0.7137988 0.2558961 0.36274953 0.13142496 -1.4447263 0.05218333 0.09536667 0.05673333 -0.038633333 0.93932519 0.01373985 FALSE TRUE
MSTRG.11947.3 ENSG00000213918 HEK293_OSMI2_2hA HEK293_TMG_2hB DNASE1 protein_coding   7.257599 7.541925 4.671123 0.3644327 0.2060865 -0.6899896 1.2367901 1.1517741 0.7697216 0.10481807 0.13395971 -0.5752987 0.17413750 0.15310000 0.16293333 0.009833333 0.93258370 0.01373985 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000213918 E001 0.1472490 0.0431155240 0.2184898861   16 3611728 3611729 2 + 0.176 0.000 -10.743
ENSG00000213918 E002 0.7384326 0.0216145814 0.8081948972 0.878126283 16 3611730 3611746 17 + 0.176 0.214 0.351
ENSG00000213918 E003 0.8856816 0.1091879051 0.6953919535 0.795997169 16 3611747 3611751 5 + 0.301 0.215 -0.639
ENSG00000213918 E004 5.0561934 0.0031925791 0.0436957244 0.097828168 16 3611752 3611821 70 + 0.929 0.643 -1.144
ENSG00000213918 E005 5.3507179 0.0045149840 0.0219357123 0.055542775 16 3611822 3611863 42 + 0.977 0.663 -1.239
ENSG00000213918 E006 9.5473412 0.0018844633 0.0006197402 0.002605822 16 3611864 3612006 143 + 1.217 0.841 -1.384
ENSG00000213918 E007 19.5456494 0.0247603953 0.0002108396 0.001010293 16 3640715 3641237 523 + 1.512 1.101 -1.438
ENSG00000213918 E008 0.0000000       16 3642880 3642891 12 +      
ENSG00000213918 E009 4.8583192 0.0632637528 0.0143173493 0.038952492 16 3642892 3642937 46 + 0.978 0.554 -1.721
ENSG00000213918 E010 7.2615676 0.0447294000 0.0025158232 0.008811684 16 3642938 3643036 99 + 1.146 0.686 -1.756
ENSG00000213918 E011 2.2925325 0.0769633553 0.0402391625 0.091474239 16 3650758 3651016 259 + 0.740 0.353 -1.843
ENSG00000213918 E012 24.2594584 0.0464049530 0.0034321474 0.011529569 16 3651317 3651921 605 + 1.580 1.209 -1.285
ENSG00000213918 E013 22.6490454 0.0008658330 0.0002089269 0.001002091 16 3651922 3652512 591 + 1.512 1.222 -1.005
ENSG00000213918 E014 35.7981020 0.0008953281 0.3703702550 0.514813921 16 3654098 3654603 506 + 1.484 1.521 0.128
ENSG00000213918 E015 9.3957283 0.0018768522 0.3874854288 0.531625788 16 3654604 3654624 21 + 0.903 0.986 0.313
ENSG00000213918 E016 11.9828936 0.0014755348 0.2315884506 0.364362095 16 3654625 3654666 42 + 0.977 1.088 0.403
ENSG00000213918 E017 11.9111334 0.0218628587 0.1287506704 0.232416632 16 3654667 3654690 24 + 0.903 1.086 0.676
ENSG00000213918 E018 22.1620810 0.0085457925 0.9522111546 0.974084045 16 3654691 3654825 135 + 1.311 1.297 -0.051
ENSG00000213918 E019 16.3119749 0.0015913470 0.8257198160 0.890274555 16 3654826 3654859 34 + 1.176 1.176 0.002
ENSG00000213918 E020 20.9291709 0.0041654235 0.2443739325 0.379328524 16 3654860 3654960 101 + 1.217 1.299 0.289
ENSG00000213918 E021 26.7465332 0.0012947449 0.1245330827 0.226449540 16 3654961 3655044 84 + 1.311 1.408 0.336
ENSG00000213918 E022 0.0000000       16 3655045 3655372 328 +      
ENSG00000213918 E023 39.1589311 0.0007238927 0.2787079997 0.418367385 16 3655373 3655520 148 + 1.512 1.559 0.161
ENSG00000213918 E024 5.6764425 0.0030040744 0.2212810034 0.351961945 16 3655849 3655937 89 + 0.653 0.814 0.656
ENSG00000213918 E025 1.5437022 0.0088670668 0.3973915798 0.541148955 16 3655938 3655966 29 + 0.477 0.314 -0.913
ENSG00000213918 E026 0.5202097 0.0204600168 0.2072611284 0.335228671 16 3655967 3656056 90 + 0.301 0.084 -2.235
ENSG00000213918 E027 0.0000000       16 3656070 3656101 32 +      
ENSG00000213918 E028 20.1168250 0.0078438767 0.9659251047 0.982563337 16 3656102 3656118 17 + 1.290 1.268 -0.075
ENSG00000213918 E029 23.6699953 0.0008578769 0.4525385482 0.593379547 16 3656119 3656163 45 + 1.311 1.350 0.135
ENSG00000213918 E030 19.5349894 0.0009936924 0.7316896422 0.823303805 16 3656164 3656185 22 + 1.255 1.264 0.033
ENSG00000213918 E031 29.4721325 0.0007201717 0.5574061819 0.685822512 16 3656638 3656710 73 + 1.415 1.436 0.073
ENSG00000213918 E032 26.4860669 0.0007846563 0.2377680165 0.371562797 16 3656711 3656753 43 + 1.332 1.401 0.238
ENSG00000213918 E033 6.6683861 0.0229730836 0.3088075135 0.451075261 16 3656964 3656998 35 + 0.740 0.876 0.537
ENSG00000213918 E034 33.2888367 0.0007761039 0.0066263447 0.020255121 16 3656999 3657111 113 + 1.352 1.521 0.584
ENSG00000213918 E035 19.1286851 0.0010210356 0.0205046703 0.052553551 16 3657112 3657161 50 + 1.097 1.289 0.683
ENSG00000213918 E036 17.0437966 0.0010808638 0.0109810605 0.031115633 16 3657162 3657186 25 + 1.021 1.249 0.819
ENSG00000213918 E037 24.6954770 0.0012905694 0.4543439679 0.594971344 16 3657187 3657224 38 + 1.332 1.370 0.132
ENSG00000213918 E038 23.2433964 0.0014943505 0.0130690389 0.036071713 16 3657225 3657249 25 + 1.190 1.378 0.658
ENSG00000213918 E039 23.2560531 0.0037917775 0.0019691306 0.007129400 16 3657250 3657271 22 + 1.130 1.389 0.910
ENSG00000213918 E040 30.6806384 0.0059836938 0.0047270524 0.015169149 16 3657272 3657341 70 + 1.278 1.492 0.742
ENSG00000213918 E041 26.0866777 0.0007792007 0.3024508940 0.444328754 16 3657720 3657789 70 + 1.332 1.390 0.200
ENSG00000213918 E042 21.1873896 0.0009640958 0.4464706751 0.587950299 16 3657790 3657816 27 + 1.255 1.298 0.152
ENSG00000213918 E043 8.5996642 0.0276549820 0.1508517979 0.262835995 16 3657817 3657867 51 + 1.079 0.867 -0.788
ENSG00000213918 E044 5.8079263 0.0546194433 0.9293211230 0.959546406 16 3657868 3657905 38 + 0.813 0.782 -0.121
ENSG00000213918 E045 97.9726586 0.0064731983 0.0014787690 0.005568664 16 3657906 3662645 4740 + 2.062 1.882 -0.604
ENSG00000213918 E046 11.5848958 0.0019497619 0.1071340519 0.201307500 16 3662646 3662804 159 + 1.176 0.996 -0.652
ENSG00000213918 E047 34.7722358 0.0043348218 0.4667713847 0.606317228 16 3662805 3663486 682 + 1.550 1.478 -0.247
ENSG00000213918 E048 98.5885073 0.0003503961 0.0018915588 0.006888382 16 3663487 3665472 1986 + 1.863 1.964 0.341
ENSG00000213918 E049 0.6696487 0.0260999024 0.0742544753 0.150334900 16 3679749 3680143 395 + 0.398 0.084 -2.820