ENSG00000213904

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000593491 ENSG00000213904 HEK293_OSMI2_2hA HEK293_TMG_2hB LIPE-AS1 lncRNA lncRNA 44.53248 88.5926 25.06677 3.169097 2.105704 -1.820997 37.340726 75.654914 19.669631 2.0358889 1.9360528 -1.942921 0.8321458 0.85453333 0.78270000 -0.07183333 0.02127041 1.139572e-08    
MSTRG.17235.3 ENSG00000213904 HEK293_OSMI2_2hA HEK293_TMG_2hB LIPE-AS1 lncRNA   44.53248 88.5926 25.06677 3.169097 2.105704 -1.820997 3.396245 6.467589 2.248626 0.8664238 0.1486333 -1.520012 0.0713500 0.07246667 0.09023333 0.01776667 0.48134049 1.139572e-08    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000213904 E001 0.9880035 0.1278483204 2.743970e-01 4.135405e-01 19 42397114 42397116 3 + 0.000 0.272 9.717
ENSG00000213904 E002 3.3172792 0.0687504688 9.903885e-01 9.981175e-01 19 42397117 42397127 11 + 0.543 0.536 -0.029
ENSG00000213904 E003 50.6700994 0.0004964073 6.403796e-02 1.334147e-01 19 42397128 42397158 31 + 1.514 1.619 0.358
ENSG00000213904 E004 60.7966169 0.0004361088 3.509878e-03 1.175442e-02 19 42397159 42397167 9 + 1.546 1.706 0.544
ENSG00000213904 E005 101.1073903 0.0002950198 1.912274e-02 4.960626e-02 19 42397168 42397173 6 + 1.821 1.911 0.304
ENSG00000213904 E006 104.3064675 0.0002894054 4.504803e-02 1.002857e-01 19 42397174 42397175 2 + 1.849 1.922 0.248
ENSG00000213904 E007 188.3587185 0.0002275814 3.424613e-01 4.864568e-01 19 42397176 42397224 49 + 2.152 2.169 0.056
ENSG00000213904 E008 29.9816631 0.0007278905 2.612312e-01 3.988770e-01 19 42400568 42400724 157 + 1.452 1.359 -0.323
ENSG00000213904 E009 17.0262920 0.0012919748 3.813218e-01 5.256170e-01 19 42401169 42401360 192 + 1.086 1.166 0.287
ENSG00000213904 E010 0.5911836 0.0279622390 5.254785e-01 6.588483e-01 19 42401582 42401647 66 + 0.000 0.180 11.080
ENSG00000213904 E011 9.3034539 0.0018588318 5.598812e-03 1.755057e-02 19 42407968 42408127 160 + 0.542 0.963 1.721
ENSG00000213904 E012 214.5920008 0.0003473923 4.791607e-03 1.535160e-02 19 42408258 42408452 195 + 2.167 2.235 0.225
ENSG00000213904 E013 0.5169874 0.0213871543 6.338580e-01 7.484666e-01 19 42423755 42424268 514 + 0.210 0.127 -0.864
ENSG00000213904 E014 0.3697384 0.0274424043 9.196107e-01 9.532113e-01 19 42424269 42424312 44 + 0.000 0.127 10.521
ENSG00000213904 E015 3.0925020 0.0058424647 1.591623e-02 4.254367e-02 19 42424313 42425142 830 + 0.819 0.432 -1.713
ENSG00000213904 E016 1.3577445 0.0367940523 9.505156e-02 1.829483e-01 19 42425143 42425204 62 + 0.542 0.227 -1.859
ENSG00000213904 E017 0.1482932 0.0414400844 1.000000e+00   19 42450602 42450733 132 + 0.000 0.068 9.470
ENSG00000213904 E018 0.3030308 0.2534479511 4.559650e-02   19 42460848 42461042 195 + 0.351 0.000 -13.221
ENSG00000213904 E019 7.7927752 0.0024377632 6.553205e-06 4.542572e-05 19 42485096 42485134 39 + 1.218 0.692 -1.985
ENSG00000213904 E020 12.0616346 0.0014582802 1.204683e-10 2.097767e-09 19 42485135 42485223 89 + 1.433 0.810 -2.257
ENSG00000213904 E021 0.3289534 0.0286320504 3.558609e-01   19 42485224 42485724 501 + 0.210 0.068 -1.864
ENSG00000213904 E022 0.7782011 0.0159760705 7.022753e-02 1.437396e-01 19 42510897 42510974 78 + 0.457 0.127 -2.451
ENSG00000213904 E023 8.9775560 0.0176440596 3.497066e-02 8.159878e-02 19 42521992 42522098 107 + 1.107 0.824 -1.060
ENSG00000213904 E024 10.0644466 0.0100311564 1.550914e-01 2.685287e-01 19 42525618 42525869 252 + 1.086 0.903 -0.676
ENSG00000213904 E025 3.8010800 0.0102115707 1.703433e-10 2.889598e-09 19 42651087 42651181 95 + 1.147 0.226 -4.257
ENSG00000213904 E026 1.9208300 0.0073702301 7.168220e-03 2.166038e-02 19 42651182 42651286 105 + 0.728 0.268 -2.350
ENSG00000213904 E027 2.9161994 0.0054573934 2.141789e-06 1.654929e-05 19 42651287 42651415 129 + 0.987 0.268 -3.351
ENSG00000213904 E028 4.3973216 0.0267113363 8.331340e-09 1.042089e-07 19 42651416 42651716 301 + 1.166 0.307 -3.735
ENSG00000213904 E029 6.5916444 0.0287662618 1.004435e-08 1.237560e-07 19 42651717 42652355 639 + 1.279 0.486 -3.125