ENSG00000213585

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395044 ENSG00000213585 HEK293_OSMI2_2hA HEK293_TMG_2hB VDAC1 protein_coding protein_coding 219.9387 285.9993 202.3377 24.47361 4.816362 -0.4992255 59.23392 86.29527 45.28473 7.885164 1.961615 -0.9301056 0.2644333 0.3014667 0.2236333 -0.07783333 2.309338e-09 2.309338e-09 FALSE  
ENST00000395047 ENSG00000213585 HEK293_OSMI2_2hA HEK293_TMG_2hB VDAC1 protein_coding protein_coding 219.9387 285.9993 202.3377 24.47361 4.816362 -0.4992255 156.42334 196.49316 151.77387 16.545721 3.323762 -0.3725341 0.7136875 0.6871667 0.7502000 0.06303333 1.787922e-08 2.309338e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000213585 E001 0.000000       5 133971871 133971914 44 -      
ENSG00000213585 E002 198.178541 2.192334e-04 2.423075e-10 4.000735e-09 5 133971915 133971951 37 - 2.137 2.352 0.716
ENSG00000213585 E003 335.235123 4.560360e-03 2.971366e-05 1.770289e-04 5 133971952 133971972 21 - 2.372 2.571 0.663
ENSG00000213585 E004 1749.888540 2.054667e-03 3.364383e-22 2.735503e-20 5 133971973 133972136 164 - 3.042 3.300 0.859
ENSG00000213585 E005 3581.766773 1.004056e-03 1.069976e-17 5.237825e-16 5 133972137 133972372 236 - 3.426 3.586 0.532
ENSG00000213585 E006 3847.921378 3.500563e-04 3.275375e-21 2.404146e-19 5 133972373 133972725 353 - 3.484 3.608 0.411
ENSG00000213585 E007 1608.354315 4.951644e-04 7.413620e-06 5.073101e-05 5 133972726 133972862 137 - 3.127 3.220 0.310
ENSG00000213585 E008 1259.551740 7.028735e-04 5.471825e-01 6.772555e-01 5 133973791 133973848 58 - 3.069 3.091 0.076
ENSG00000213585 E009 2057.766673 7.877407e-04 3.209150e-02 7.603539e-02 5 133975871 133976021 151 - 3.297 3.295 -0.004
ENSG00000213585 E010 8.955675 3.165862e-03 2.042489e-08 2.377679e-07 5 133976022 133976369 348 - 1.270 0.695 -2.155
ENSG00000213585 E011 2758.763874 3.009838e-04 2.957435e-13 7.860231e-12 5 133980729 133980956 228 - 3.450 3.409 -0.137
ENSG00000213585 E012 8.675156 1.874214e-02 6.697087e-01 7.763975e-01 5 133980957 133981033 77 - 0.914 1.008 0.348
ENSG00000213585 E013 3.072934 7.393818e-03 6.941052e-01 7.950046e-01 5 133981034 133981038 5 - 0.624 0.591 -0.143
ENSG00000213585 E014 10.585267 5.308881e-03 1.399995e-01 2.480231e-01 5 133981039 133981194 156 - 1.128 1.010 -0.429
ENSG00000213585 E015 24.376721 4.451841e-02 3.983463e-01 5.420788e-01 5 133988788 133989243 456 - 1.298 1.422 0.430
ENSG00000213585 E016 1502.046751 6.253744e-05 9.156107e-25 9.799983e-23 5 133990855 133990907 53 - 3.202 3.140 -0.207
ENSG00000213585 E017 2250.709216 7.417737e-05 1.224383e-50 7.706168e-48 5 133991002 133991154 153 - 3.391 3.306 -0.284
ENSG00000213585 E018 1033.314676 4.018307e-04 2.486966e-20 1.650257e-18 5 133992306 133992355 50 - 3.061 2.962 -0.328
ENSG00000213585 E019 1124.994992 5.064252e-04 5.884372e-25 6.421524e-23 5 133992946 133993015 70 - 3.109 2.989 -0.401
ENSG00000213585 E020 600.564317 1.289385e-03 3.999394e-14 1.203229e-12 5 133993016 133993018 3 - 2.847 2.708 -0.465
ENSG00000213585 E021 2.378117 1.987385e-01 5.252752e-01 6.586653e-01 5 134004487 134004646 160 - 0.580 0.463 -0.556
ENSG00000213585 E022 766.245660 1.982825e-03 7.034905e-13 1.769482e-11 5 134004647 134004894 248 - 2.958 2.808 -0.500
ENSG00000213585 E023 10.844367 3.601919e-02 7.598859e-02 1.530915e-01 5 134004895 134005556 662 - 1.177 0.976 -0.730